Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Andrew A Beharry"'
Autor:
Zachary D Nagel, Andrew A Beharry, Patrizia Mazzucato, Gaspar J Kitange, Jann N Sarkaria, Eric T Kool, Leona D Samson
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0208341 (2019)
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) strongly influences the effectiveness of cancer treatment with chemotherapeutic alkylating agents, and MGMT status in cancer cells could potentially contribute to tailored therapies
Externí odkaz:
https://doaj.org/article/6cb244a315884924966a4e8becf14c02
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152684 (2016)
Common alkylating antitumor drugs, such as temozolomide, trigger their cytotoxicity by methylating the O6-position of guanosine in DNA. However, the therapeutic effect of these drugs is dampened by elevated levels of the DNA repair enzyme, O6-methylg
Externí odkaz:
https://doaj.org/article/3911c5f397ff4229a597e63060aaa398
Autor:
Elyse M. Digby, Matthew T. Tung, Husain N. Kagalwala, Lucas S. Ryan, Alexander R. Lippert, Andrew A. Beharry
Publikováno v:
ACS Chem Biol
Reactive oxygen species (e.g., singlet oxygen) are the primary cytotoxic agents used in the clinically approved technique photodynamic therapy (PDT). Although singlet oxygen has high potential to effectively kill tumor cells, its production via light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3644a4a70f51a10f7eab0f79bc10b9b8
https://pubmed.ncbi.nlm.nih.gov/35771988
https://pubmed.ncbi.nlm.nih.gov/35771988
Autor:
Cagri Ozsan, Karishma Kailass, Elyse M. Digby, Toghrul Almammadov, Andrew A. Beharry, Safacan Kolemen
Publikováno v:
Chemical Communications. 58:10929-10932
Carboxylesterase 2 (CES2) has crucial roles in both xenobiotic metabolism and formation of pathogenic states including cancer. Thus, it is highly critical to monitor intracellular CES2 activity in living cancer cells. Here, we report a CES2 activatab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6604841d699e2121cbb173329994b5b
https://doi.org/10.1039/d2cc03309g
https://doi.org/10.1039/d2cc03309g
Publikováno v:
ACS Infectious Diseases. 7:3052-3061
Antimicrobial photodynamic therapy (APDT) employs a photosensitizer, light, and molecular oxygen to treat infectious diseases via oxidative damage, with a low likelihood for the development of resistance. For optimal APDT efficacy, photosensitizers w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72af3b4661cc5c323bbec87cf785b18e
https://doi.org/10.1021/acsinfecdis.1c00313
https://doi.org/10.1021/acsinfecdis.1c00313
Publikováno v:
Journal of medicinal chemistry. 65(13)
Human carboxylesterase 2 (hCES2) converts anticancer prodrugs, such as irinotecan, into their active metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d01c104a274c63f11361bbeaee1085
https://pubmed.ncbi.nlm.nih.gov/35700557
https://pubmed.ncbi.nlm.nih.gov/35700557
Autor:
Andrew A. Beharry, Katherine N. Robertson, Alison Thompson, Roberto M. Diaz-Rodriguez, Matthew T. Tung, Jacob W. Campbell
Publikováno v:
ACS Med Chem Lett
[Image: see text] The synthesis and characterization of the first BODIPY appended to the five-membered heterocylic tellurophene [Te] moiety is reported. By incorporating tellurophene at the meso position, the tellurophene-appended boron-dipyrromethen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b522417a199037052e05aefadd9c93
https://pubmed.ncbi.nlm.nih.gov/34917256
https://pubmed.ncbi.nlm.nih.gov/34917256
Antimicrobial photodynamic therapy (APDT) employs a photosensitizer, light, and molecular oxygen to treat infectious diseases via oxidative damage, with a low likelihood for the development of resistance. For optimal APDT efficacy, photosensitizers w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6aa1016877f113d10094fee8259553a
https://doi.org/10.1101/2021.06.11.448055
https://doi.org/10.1101/2021.06.11.448055
Autor:
Elyse M. Digby, Matthew T. Tung, Husain N. Kagalwala, Lucas S. Ryan, Alexander R. Lippert, Andrew A. Beharry
Publikováno v:
ACS Chemical Biology. 17:1996-1996
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::906220e6115af3f4353159e8956af1ef
https://doi.org/10.1021/acschembio.2c00509
https://doi.org/10.1021/acschembio.2c00509
Autor:
Jason B. Fleming, Karishma Kailass, Ya'an Kang, Andrew A. Beharry, Oleg Sadovski, Michela Capello, Samir M. Hanash
Publikováno v:
Chemical Science. 10:8428-8437
Irinotecan-based therapy is a common treatment for pancreatic cancer. To elicit its anticancer activity, the drug requires first the hydrolysis action of the enzyme human carboxylesterase 2 (hCES2). It has been established that pancreatic cancer pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2798f8f25fe389f031d437a50a6ae0b
https://doi.org/10.1039/c9sc00283a
https://doi.org/10.1039/c9sc00283a