Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Andrew J. Hutt"'
Autor:
Andrew J. Hutt
Publikováno v:
Smith and Williams' Introduction to the Principles of Drug Design and Action ISBN: 9781315273792
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1529eba171c3dbbc04b1488263e5939a
https://doi.org/10.1201/9781315273792-4
https://doi.org/10.1201/9781315273792-4
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(9)
1. Formation of 1-O-acyl-β-d-glucuronide conjugates is a significant pathway in the metabolism of drugs containing a carboxylic acid group. The formation of acyl glucuronides results in an increase in both the aqueous solubility and molecular mass o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e11cefadf6ecc0c4c387efbba979fdb
https://pubmed.ncbi.nlm.nih.gov/28967291
https://pubmed.ncbi.nlm.nih.gov/28967291
Publikováno v:
Journal of Chemical Information and Modeling. 52:420-428
The General Solubility Equation (GSE) is a QSPR model based on the melting point and log P of a chemical substance. It is used to predict the aqueous solubility of nonionizable chemical compounds. However, its reliance on experimentally derived descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256ee5ce5a60a58f4aa06f5e78eb0bb8
https://doi.org/10.1021/ci200387c
https://doi.org/10.1021/ci200387c
Autor:
Fergus Manford, Yanira Riffo-Vasquez, Domenico Spina, Clive P Page, Andrew J Hutt, Vanessa Moore, Fredrik Johansson, Ben Forbes
Publikováno v:
Journal of Pharmacy and Pharmacology. 60:1305-1310
Although in-vitro experiments have suggested that P-glycoprotein (P-gp) may have an important influence on the disposition of inhaled drugs, the effect of P-gp on absorption from the lung in-vivo has not been reported previously. The aim of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2697b7d41052f0f8b97260f1487161b
https://doi.org/10.1211/jpp.60.10.0006
https://doi.org/10.1211/jpp.60.10.0006
Publikováno v:
Journal of Chromatography A. 1130:137-144
Alendronate and pamidronate are amino bisphosphonate analogues of pyrophosphate used for the treatment of a variety of bone diseases. Analysis of these compounds is problematic due to their polar ionic nature, lack of a suitable chromophore and chela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857d908da8debd907b291e714466bb9f
https://doi.org/10.1016/j.chroma.2006.06.110
https://doi.org/10.1016/j.chroma.2006.06.110
Publikováno v:
ELECTROPHORESIS. 25:2625-2656
The 2-arylpropionic acids (2-APAs) are an important group of nonsteroidal anti-inflammatory drugs. These agents, the majority of which are available as racemates, exhibit stereoselectivity in both their action and disposition. Developments in stereos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1e7e07271738fd69d10c97353aaf76
https://doi.org/10.1002/elps.200405928
https://doi.org/10.1002/elps.200405928
Publikováno v:
Chromatographia. 58:733-740
The chromatographic retention and resolution of the enantiomers of a novel series of aryloxyaminopropanol derivatives with β-adrenoceptor antagonist activity have been investigated using a Chiralpak AD CSP. The influence of mobile phase composition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3fcc8da8d769a24db61db3f50b741a
https://doi.org/10.1365/s10337-003-0114-7
https://doi.org/10.1365/s10337-003-0114-7
Publikováno v:
ELECTROPHORESIS. 24:2508-2513
The enantiomeric resolution of 1,1'-binaphthyl-2,2'-diamine and Tröger's base was investigated using the commercially available zwitterionic surfactants 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulphonate (CHAPS) and 3-[(3-cholamidopropyl)dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2058058501c8e38ff69610bb447fbe
https://doi.org/10.1002/elps.200305467
https://doi.org/10.1002/elps.200305467
Publikováno v:
British Journal of Clinical Pharmacology. 55:579-587
Aims To determine the influence of age on the enantioselective disposition of ibuprofen in humans. Methods Healthy young (n = 16; aged 20–36 years) and elderly (n = 16; aged 66–84 years) volunteers were given a 400-mg oral dose of racemic ibuprof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b2fc596cbf2ffe1020ae92bbd2fb2f3
https://doi.org/10.1046/j.1365-2125.2003.01806.x
https://doi.org/10.1046/j.1365-2125.2003.01806.x
Publikováno v:
Chromatographia. 57:7-18
Direct chiral-phase HPLC methods have been developed for the determination of flurbiprofen and its major metabolites, namely 4′-hydroxyflurbiprofen and 3′-hydroxy-4′-methoxyflurbiprofen, in biological fluids using a derivatized amylose chiral s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f538205e109c3fec805f9c3bdf90402
https://doi.org/10.1007/bf02497471
https://doi.org/10.1007/bf02497471