Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Andrew Coop"'
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 398 (2022)
There is substantial evidence that cholinergic system function impairment plays a significant role in many central nervous system (CNS) disorders. During the past three decades, muscarinic receptors (mAChRs) have been implicated in various pathologie
Externí odkaz:
https://doaj.org/article/58219d084dc5447082d6c51a0191f535
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 10886-10890 (2018)
Externí odkaz:
https://doaj.org/article/cd355784054a468ea955d601fac145c4
Publikováno v:
Biomedicines. 10(2)
There is substantial evidence that cholinergic system function impairment plays a significant role in many central nervous system (CNS) disorders. During the past three decades, muscarinic receptors (mAChRs) have been implicated in various pathologie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891d8a2d95166175f3fb74003b6505a5
https://pubmed.ncbi.nlm.nih.gov/35203607
https://pubmed.ncbi.nlm.nih.gov/35203607
Publikováno v:
J Pharm Sci Pharmacol
Opioid analgesics are the treatment of choice for chronic, severe pain. During the course of developing new derivatives of morphine and codeine, we observed an unanticipated S(N)2′ substitution reaction product during an attempted 3-O-demethylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::739012d261f9e67846c4c9eab85286cc
https://pubmed.ncbi.nlm.nih.gov/34584903
https://pubmed.ncbi.nlm.nih.gov/34584903
Autor:
Kellie Hom, Mohd. Imran Ansari, Jeffrey R. Deschamps, Rae R. Matsumoto, Jason R. Healy, Andrew Coop
Publikováno v:
Organic Letters. 20:2984-2987
During optimization of the synthesis of the mixed μ opioid agonist/δ opioid antagonist 5-(hydroxymethyl)oxymorphone (UMB425) for scale-up, it was unexpectedly discovered that the 4,5-epoxy bridge underwent rearrangement on treatment with boron trib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd55318bc7f899debf82e5ef2fed8250
https://doi.org/10.1021/acs.orglett.8b01025
https://doi.org/10.1021/acs.orglett.8b01025
Autor:
Mohammad Saquib, Mohd. Kamil Hussain, Shahnaaz Khatoon, Andrew Coop, Chad R. Johnson, Mohd. Imran Ansari
Publikováno v:
European journal of medicinal chemistry. 182
The emergence of drug resistance, coupled with the issue of low tumor selectivity and toxicity is a major pitfall in cancer chemotherapy. It has necessitated the urgent need for the discovery of less toxic and more potent new anti-cancer pharmaceutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c410cb49b966c05f1027a84350b9f9
https://pubmed.ncbi.nlm.nih.gov/31499361
https://pubmed.ncbi.nlm.nih.gov/31499361
Autor:
Mohd. Imran Ansari, Jasmine S. Felix, Lance R. McMahon, Luis F. Restrepo, Jenny L. Wilkerson, Andrew Coop
Publikováno v:
J Pharmacol Exp Ther
Better therapeutic options are needed for pain. Baclofen, buspirone, and morphine are characterized as having analgesic properties. However, little is known about potential interactions between analgesic effects of these drugs when combined. Furtherm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b31159048062f6cd247d348c8b5ebf
https://pubmed.ncbi.nlm.nih.gov/31235534
https://pubmed.ncbi.nlm.nih.gov/31235534
Publikováno v:
Drug and Alcohol Dependence. 221:108530
Illicitly manufactured fentanyl and its analogs (i.e., fentanyl-related compounds) have flooded the street drug market in recent years and the continuing rise in opioid-related overdose deaths in the United States (U.S.) is now attributed primarily t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9153cefa1469dc8d99bb7086890d24f
https://doi.org/10.1016/j.drugalcdep.2021.108530
https://doi.org/10.1016/j.drugalcdep.2021.108530
Publikováno v:
The Journal of Physical Chemistry B. 120:11897-11904
G-protein coupled receptors (GPCRs), including the μ-opioid receptor, interact with G-proteins and other proteins via their intracellular face as required for signal transduction. However, characterization of the structure of the intracellular face
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e8005bcc04af5ce16d26c3f2260476
https://doi.org/10.1021/acs.jpcb.6b09351
https://doi.org/10.1021/acs.jpcb.6b09351