Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Andrew Alt"'
Autor:
Dike Qiu, Ke Xu, Namjin Chung, Jennifer Robbins, Robert Luo, Michael Lawrence, Aiqing He, Fei Yu, Andrew Alt, Michael M. Miller, Jon Hangeland, John N. Feder, Dietmar Seiffert, Brian J. Arey
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Vascular endothelial cells are exposed to mechanical forces due to their presence at the interface between the vessel wall and flowing blood. The patterns of these mechanical forces (laminar vs. turbulent) regulate endothelial cell function and play
Externí odkaz:
https://doaj.org/article/f3f3dd00eded4a689dfaf7ecdb19176f
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug targets because they can produce fewer on-target side effects, improved selectivity, and better biological specificity (e.g., biased signaling or probe dependence)
Externí odkaz:
https://doaj.org/article/56b4d636375d43ff99dc8379bb8f75d3
Autor:
Bryony L. Winters, Gabrielle C. Gregoriou, Sarah A. Kissiwaa, Oliver A. Wells, Danashi I. Medagoda, Sam M. Hermes, Neil T. Burford, Andrew Alt, Sue A. Aicher, Elena E. Bagley
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid re
Externí odkaz:
https://doaj.org/article/d5dae2c2b5f34eefb24b94cf971ec920
Publikováno v:
ACS Pharmacology & Translational Science. 5:694-709
G protein-coupled receptors (GPCRs) are highly druggable targets that adopt numerous conformations. A ligand's ability to stabilize specific conformation(s) of its cognate receptor determines its efficacy or ability to produce a biological response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afe7edffe197ccf654084ecf519891d
https://doi.org/10.1021/acsptsci.1c00256
https://doi.org/10.1021/acsptsci.1c00256
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df8b0f6248942ee4a5c1ba9f9d480469
https://doi.org/10.1124/jpet.122.235890
https://doi.org/10.1124/jpet.122.235890
Coronal mass ejections (CMEs) are some of the most energetic and violent events in our solar system. The prediction and understanding of CMEs is of particular importance due to the impact that they can have on Earth-based satellite systems, and in ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd23afda7bce85a3c5dd162b50e4808
Publikováno v:
Advances and Applications in Statistics. 60:105-135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6cfde1114908a9d7039801ef2d18c6a
https://doi.org/10.17654/as060020105
https://doi.org/10.17654/as060020105
Autor:
Caitlin E. Scott, Neil T. Burford, Andrew Alt, Litao Zhang, Samuel Gerritz, Lisa M. Ogawa, Debra A. Kendall, Yaliang Tang
Publikováno v:
Eur J Pharmacol
Cannabinoid CB(1) and CB(2) receptors are activated by Δ(9)-tetrahydrocannabinol, a psychoactive component of marijuana. The cannabinoid CB(1) receptor is primarily located in the brain and is responsible for the psychoactive side effects, whereas t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50585daa36eab7645009a747e8e7612b
https://doi.org/10.1016/j.ejphar.2019.03.054
https://doi.org/10.1016/j.ejphar.2019.03.054
Autor:
Kathryn E. Livingston, Shainnel O. Eans, Andrew D. White, Neil T. Burford, Jay P. McLaughlin, Bernard P. Roques, Andrew Alt, Todd M. Hillhouse, Ram Kandasamy, Minghua Li, Susan L. Ingram, Claire Meurice, Kelsey E Kochan, John R. Traynor
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (16), pp.e2000017118. ⟨10.1073/pnas.2000017118⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (16), pp.e2000017118. ⟨10.1073/pnas.2000017118⟩
International audience; Positive allosteric modulators (PAMs) of the mu-opioid receptor (MOR) have been hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on the idea that PAMs will promote the action of endogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592cc679812be187baac01d7115fa3bf
https://europepmc.org/articles/PMC8072371/
https://europepmc.org/articles/PMC8072371/