Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrew, Yongky"'
Autor:
Caitlin Morris, Ashli Polanco, Andrew Yongky, Jianlin Xu, Zhuangrong Huang, Jia Zhao, Kevin S. McFarland, Seoyoung Park, Bethanne Warrack, Michael Reily, Michael C. Borys, Zhengjian Li, Seongkyu Yoon
Publikováno v:
Bioresources and Bioprocessing, Vol 7, Iss 1, Pp 1-13 (2020)
Abstract Recent advances in metabolite quantification and identification have enabled new research into the detection and control of titer inhibitors and promoters. This paper presents a bigdata analytics study to identify both inhibitors and promote
Externí odkaz:
https://doaj.org/article/e723f749644b4b40bb36b7119e45666a
Autor:
Yongyan Weng, Shaoyan Liang, Shijie Liu, Zheng Jian Li, Peifeng Tang, Andrew Yongky, Zhijun Tan, Jianlin Xu, Alastair Louey
Publikováno v:
Critical Reviews in Biotechnology. 40:265-281
As a host for therapeutic protein expression, Chinese hamster ovary (CHO) cells are widely utilized in the mainstream biopharmaceutical industry. Cell culture process development plays an important role in transitioning laboratory research to manufac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9decab6d5a69e676d16a46cdbb6e9374
https://doi.org/10.1080/07388551.2019.1711015
https://doi.org/10.1080/07388551.2019.1711015
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121561 (2015)
Cultured mammalian cells exhibit elevated glycolysis flux and high lactate production. In the industrial bioprocesses for biotherapeutic protein production, glucose is supplemented to the culture medium to sustain continued cell growth resulting in t
Externí odkaz:
https://doaj.org/article/7b988fd8f51041bd8db15ce30ad127ff
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98756 (2014)
The flux of glycolysis is tightly controlled by feed-back and feed-forward allosteric regulations to maintain the body's glucose homeostasis and to respond to cell's growth and energetic needs. Using a mathematical model based on reported mechanisms
Externí odkaz:
https://doaj.org/article/d141004305a44cbea637ebfcfd05a97c
Autor:
Ashli Polanco, Seo-Young Park, Zheng Jian Li, Kevin S. McFarland, Jia Zhao, Jianlin Xu, Michael D. Reily, Andrew Yongky, Caitlin Morris, Zhuangrong Huang, Seongkyu Yoon, Bethanne M. Warrack, Michael C. Borys
Publikováno v:
Bioresources and Bioprocessing, Vol 7, Iss 1, Pp 1-13 (2020)
Recent advances in metabolite quantification and identification have enabled new research into the detection and control of titer inhibitors and promoters. This paper presents a bigdata analytics study to identify both inhibitors and promoters using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e7de6b5a1049536e2f248dff3488cf
https://doi.org/10.1186/s40643-020-00318-6
https://doi.org/10.1186/s40643-020-00318-6
Autor:
Michael C. Borys, Andrew Yongky, Peifeng Tang, Shijie Liu, Jianlin Xu, Zheng Jian Li, B.R Drew
Publikováno v:
mAbs. 11:191-204
Temperature shift (TS) to a hypothermic condition has been widely used during protein production processes that use Chinese hamster ovary (CHO) cells. The effect of temperature on cell growth, metabolites, protein titer and quality depends on cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c720e1f4f661cc53a67fff1e15c7c4
https://doi.org/10.1080/19420862.2018.1525262
https://doi.org/10.1080/19420862.2018.1525262
Autor:
Kevin S. McFarland, Jia Zhao, Christopher Oliveira, Zheng Jian Li, Jianlin Xu, Andrew Yongky, Michael C. Borys, Jun Tian
Publikováno v:
MAbs
Although process intensification by continuous operation has been successfully applied in the chemical industry, the biopharmaceutical industry primarily uses fed-batch, rather than continuous or perfusion methods, to produce stable monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219672292144324fe941fa66d48b5e75
https://pubmed.ncbi.nlm.nih.gov/31379298
https://pubmed.ncbi.nlm.nih.gov/31379298
Publikováno v:
Trends in Biotechnology. 34:638-651
Cultured mammalian cells are the main workhorses for producing biologics. The performance of these cell culture processes, in terms of both productivity and product quality attributes, is significantly influenced by cellular metabolism. Glucose is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d814fbc9af9218011bf9309fc8c049e2
https://doi.org/10.1016/j.tibtech.2016.04.012
https://doi.org/10.1016/j.tibtech.2016.04.012
Autor:
Ashli Polanco, Seongkyu Yoon, Michael D. Reily, Andrew Yongky, Jianlin Xu, Zhuangrong Huang, Caitlin Morris, Michael C. Borys, Zheng Jian Li
Publikováno v:
Biochemical Engineering Journal. 160:107638
Effective bioprocess development using Chinese hamster ovary (CHO) cells as hosts is hampered by the limited understanding of cellular metabolism under process conditions in bioreactors. Systematic tools such as genome-scale models have been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec8db0cfbf960ce54071da38e97db969
https://doi.org/10.1016/j.bej.2020.107638
https://doi.org/10.1016/j.bej.2020.107638
Autor:
Nandita Vishwanathan, Nitya M. Jacob, Hsu Yuan Fu, Wei Shou Hu, Huong Le, Dong-Yup Lee, Andrew Yongky, Kathryn C. Johnson, Faraaz N.K. Yusufi
Publikováno v:
Biotechnology and Bioengineering. 112:965-976
Transcriptomics is increasingly being used on Chinese hamster ovary (CHO) cells to unveil physiological insights related to their performance during production processes. The rich transcriptome data can be exploited to provide impetus for systems inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f5a63df4c639a86bec88a1069be52f6
https://doi.org/10.1002/bit.25513
https://doi.org/10.1002/bit.25513