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of 256
pro vyhledávání: '"Andrew, Worth"'
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This vo
Autor:
Giulia Russo, Elena Crispino, Emanuela Corsini, Martina Iulini, Alicia Paini, Andrew Worth, Francesco Pappalardo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6172-6181 (2022)
In many domains regulating chemicals and chemical products, there is a legal requirement to determine skin sensitivity to allergens. While many in vitro assays to detect contact hypersensitivity have been developed as alternatives to animal testing o
Externí odkaz:
https://doaj.org/article/b601ddda47c84b5da6bd1a03ee32c972
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1764-1777 (2022)
Immunotoxicity hazard identification of chemicals aims to evaluate the potential for unintended effects of chemical exposure on the immune system. Perfluorinated alkylate substances (PFAS), such as perfluorooctane sulfonate (PFOS) and perfluorooctano
Externí odkaz:
https://doaj.org/article/4ab36813fa884879be6c785f8b6354f6
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/0cdf25fd603e4227b58d1ab6f2e25867
Autor:
Francesca Pistollato, Emilio Mendoza de Gyves, Donatella Carpi, Stephanie K. Bopp, Carolina Nunes, Andrew Worth, Anna Bal-Price
Publikováno v:
Environmental Health, Vol 19, Iss 1, Pp 1-26 (2020)
Abstract Background In light of the vulnerability of the developing brain, mixture risk assessment (MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented, since infants and children are co-exposed to more than one chemica
Externí odkaz:
https://doaj.org/article/e6f721fffcac4e86bba91ff628913776
Autor:
Kiara Fairman, Me-Kyoung Choi, Pavani Gonnabathula, Annie Lumen, Andrew Worth, Alicia Paini, Miao Li
Publikováno v:
Toxics, Vol 11, Iss 2, p 126 (2023)
A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK mo
Externí odkaz:
https://doaj.org/article/ca537ecca68e4da38cc6693664d220b0
Autor:
Francesco Giorgi, Peter Macko, Judith M. Curran, Maurice Whelan, Andrew Worth, Eann A. Patterson
Publikováno v:
Royal Society Open Science, Vol 8, Iss 11 (2021)
The biological response of organisms exposed to nanoparticles is often studied in vitro using adherent monolayers of cultured cells. In order to derive accurate concentration–response relationships, it is important to determine the local concentrat
Externí odkaz:
https://doaj.org/article/bec2f43cb89648d6ace823009da0d42e
Publikováno v:
Environment International, Vol 128, Iss , Pp 417-429 (2019)
Cancer is a key public health concern, being the second leading cause of worldwide morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence, incidence and mortality rates are increasing. These trends are not fully
Externí odkaz:
https://doaj.org/article/649e52e07d094f7faacd50db6b420536
Autor:
Julia Pletz, Samantha Blakeman, Alicia Paini, Nikolaos Parissis, Andrew Worth, Anna-Maria Andersson, Hanne Frederiksen, Amrit K. Sakhi, Cathrine Thomsen, Stephanie K. Bopp
Publikováno v:
Environment International, Vol 143, Iss , Pp 105978- (2020)
Human biomonitoring (HBM) data can provide insight into co-exposure patterns resulting from exposure to multiple chemicals from various sources and over time. Therefore, such data are particularly valuable for assessing potential risks from combined
Externí odkaz:
https://doaj.org/article/0f925ea555cf44ee95c9910495857d45
Autor:
Pedro Costa del Amo, Bisrat Debebe, Milad Razavi-Mohseni, Shinji Nakaoka, Andrew Worth, Diana Wallace, Peter Beverley, Derek Macallan, Becca Asquith
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The processes governing lymphocyte fate (division, differentiation, and death), are typically assumed to be independent of cell age. This assumption has been challenged by a series of elegant studies which clearly show that, for murine cells in vitro
Externí odkaz:
https://doaj.org/article/5ecb89a9c35a4acd9a2bbd2040422dab