Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew, Siwkowski"'
Publikováno v:
BioTechniques, Vol 24, Iss 2, Pp 278-284 (1998)
Random mutagenesis followed by an in vitro selection procedure was shown to be capable of identifying important bases of the hairpin ribozyme for cleavage of an RNA target sequence. The selection scheme enriched the RNA population for those molecules
Externí odkaz:
https://doaj.org/article/73c956b7d5094003b7256a99d8d38a10
Publikováno v:
Gene Therapy. 6:1114-1119
The catalytic center of the RNA from the negative strand of the satellite RNA of chicory yellow mottle virus type 1 (sCYMV1) is in the hairpin ribozyme family, has catalytic activity, and cleaves substrates before a preferred GUA sequence. This is di
Autor:
Arnold E. Hampel, Amy E. Cullinan, Joseph A. DiPaolo, Luis M. Alvarez-Salas, Andrew Siwkowski
Publikováno v:
Proceedings of the National Academy of Sciences. 95:1189-1194
HPV-16 E6 and E7 genes are required to efficiently immortalize a broad spectrum of cell types including cervical keratinocytes. Therefore, the E6/E7 genes can be considered relevant targets for anti-cancer therapy. We produced several engineered hair
Publikováno v:
Biochemistry. 34:15785-15791
Regions of the negative strands of the satellite RNAs of chicory yellow mottle virus (sCYMV1) and arabis mosaic virus (sArMV) have similarity in sequence and predicted secondary structure compared to the tobacco ringspot virus satellite RNA (sTRSV) h
Autor:
Martin Egli, Punit P. Seth, Eric E. Swayze, Charles R. Allerson, Thazha P. Prakash, Andrew Siwkowski, Watt Andrew T, Hans Gaus, Pradeep S. Pallan, Andres Berdeja
We show for the first time that it is possible to obtain LNA-like (Locked Nucleic Acid 1) binding affinity and biological activity with carbocyclic LNA (cLNA) analogs by replacing the 2'-oxygen atom in LNA with an exocyclic methylene group. Synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdc221749887b84b042ac44dc1014fa
https://europepmc.org/articles/PMC2993159/
https://europepmc.org/articles/PMC2993159/
Autor:
Max W, Richardson, Linda, Hostalek, Michelle, Dobson, Jason, Hu, Richard, Shippy, Andrew, Siwkowski, Jonathan D, Marmur, Kamel, Khalili, Paul E, Klotman, Arnold, Hampel, Jay, Rappaport
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 252
Hairpin ribozymes derived from the negative strand of satellite RNAs from the tobacco ringspot virus (sTRSV) can be engineered to target and cleave a variety of heterologous RNAs from both cellular and viral transcripts. Attention to design and targe
Autor:
Jonathan D. Marmur, Max W. Richardson, Jason Hu, Paul E. Klotman, Kamel Khalili, Linda Hostalek, Arnold Hampel, Jay Rappaport, Andrew Siwkowski, Richard Shippy, Michelle Dobson
Hairpin ribozymes derived from the negative strand of satellite RNAs from the tobacco ringspot virus (sTRSV) can be engineered to target and cleave a variety of heterologous RNAs from both cellular and viral transcripts. Attention to design and targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::829d76cd06a4c051b545d282ab94a723
https://doi.org/10.1385/1-59259-746-7:339
https://doi.org/10.1385/1-59259-746-7:339