Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Andrew, Nortcliffe"'
Autor:
Hasnain Mehmood, Mustapha Musa, Simon Woodward, Md Shahadat Hossan, Tracey D. Bradshaw, Muhammad Haroon, Andrew Nortcliffe, Tashfeen Akhtar
Publikováno v:
RSC Advances. 12:34126-34141
Cyclization of substituted thiosemicarbazones with α-bromo-4-cyanoacetophenone allows rapid single-step sustainable syntheses of 4-cyanophenyl-2-hydrazinylthiazoles libraries (30 examples, 66-79%). All show anticancer efficacy against HCT-116 and MC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97997052f69646deb2fd33502de5cac2
https://doi.org/10.1039/d2ra03226k
https://doi.org/10.1039/d2ra03226k
Autor:
Alexandra E. Bailie, Andrew Nortcliffe
Publikováno v:
Journal of Chemical Education. 98:3333-3340
A multistep synthesis of quinolone antibiotic analogues was developed as a laboratory experiment for intermediate/advanced undergraduate students. Students can synthesize a range of desfluoroenoxacin analogues via a five-step sequence. The experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a48af3b55f579b72432711246d7dbb
https://doi.org/10.1021/acs.jchemed.1c00459
https://doi.org/10.1021/acs.jchemed.1c00459
Publikováno v:
ACS Sustainable Chemistry & Engineering. 8:12746-12754
Herein, we report our efforts to improve the sustainability of the Delepine reaction for the formation of primary amines from activated alkyl halides. A number of alternative greener, more sustaina...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4892899591400ea5f25c224d2a447d3
https://doi.org/10.1021/acssuschemeng.0c05393
https://doi.org/10.1021/acssuschemeng.0c05393
Publikováno v:
Organic & Biomolecular Chemistry. 18:6696-6701
Iridium-catalysed catalytic, regioselective C–H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::376e265aa5dd5fadc2188b600e03164b
https://doi.org/10.1039/d0ob01495h
https://doi.org/10.1039/d0ob01495h
Autor:
Harley Green, Lydia Barnes, Jolyon Matthews-Wright, Rachel Szpara, Luke Francis, Nuria S. Lima, Hollie Blaber, Carrie K. W. Wong, Alexander Seal, Charlotte S. Payne, Matthew F. Meehan, C. Elizabeth Killalea, Rohan J. Trainor, Katherine Wood, Jack M. J. Grace, Oliver Williams, Liam Cochrane, Edmund J. P. Hogarth, Katherine Louise Jones, Zoe J. Lee, Shusha Mahdy, Anna Gruszka, Lisa Morrison, Freya Taday, Leyla Jusu, Oliver King, May-Li Mackinnon, Joe Stillibrand, Daniel Buckley, Edward Cooney, Z.A. Henley, Simon J. F. Macdonald, Christina L. Long, Daniel Fu He, Craig Pike, Zoe C. Byron, Keenan M. Smith, Ian Edward David Smith, Antony M. Threadgould, Lewis Byers, Kamile Stanelyte, Hal R. I. Parke, Nick Barton, Rosa Cookson, James E. Rowedder, Andrew Nortcliffe, Aaron J. Senior, Alan Nadin, Makenzie J. Millward, Joseph Lambert, Lawrence Payne, David T. K. Brooks, Christopher Merrett, Heather A. Damian, Jordan Waters, Richard G. Chilvers
Publikováno v:
Journal of Medicinal Chemistry. 62:10402-10422
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c565e07f6df53b788d687eb5d9b250
https://doi.org/10.1021/acs.jmedchem.9b01499
https://doi.org/10.1021/acs.jmedchem.9b01499
Autor:
Gemma C. Geary, Andrew Nortcliffe, Geraint Jones, Christopher A. Pearce, Daniel Hamza, Christopher J. Moody
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:791-797
A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf04d9efc9225a24cf3459b11dbdc776
https://doi.org/10.1016/j.bmc.2017.12.012
https://doi.org/10.1016/j.bmc.2017.12.012
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2218-2225
Functionalised tetrahydropyran scaffolds were prepared using a tethered enol-ether Prins cyclisation and elaborated to show their potential use in library synthesis. The key 4-hydroxytetrahydropyran scaffold could be readily manipulated to the 4-azid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0426d8a2a358f694decb7fae13c9d5
https://doi.org/10.1016/j.bmc.2017.02.039
https://doi.org/10.1016/j.bmc.2017.02.039
Autor:
Emma Packard, Daniel Hamza, Geraint Jones, Christopher J. Moody, Andrew Nortcliffe, Alexander Murray, William Lewis
Publikováno v:
European Journal of Organic Chemistry. 2017:138-148
Analogues of the nicotinic acetylcholine antagonist epibatidine, suitable for diversification, were synthesized by application of a pyrrole Diels–Alder strategy, allowing rapid generation of azabicyclo[2.2.1]heptane bicyclic cores. Further molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ea270d1c5c0307ff867c28d5a05e571
https://doi.org/10.1002/ejoc.201601177
https://doi.org/10.1002/ejoc.201601177
Autor:
Lydia, Barnes, Hollie, Blaber, David T K, Brooks, Lewis, Byers, Daniel, Buckley, Zoe C, Byron, Richard G, Chilvers, Liam, Cochrane, Edward, Cooney, Heather A, Damian, Luke, Francis, Daniel, Fu He, Jack M J, Grace, Harley J, Green, Edmund J P, Hogarth, Leyla, Jusu, C Elizabeth, Killalea, Oliver, King, Joseph, Lambert, Zoe J, Lee, Nuria S, Lima, Christina L, Long, May-Li, Mackinnon, Shusha, Mahdy, Jolyon, Matthews-Wright, Makenzie J, Millward, Matthew F, Meehan, Christopher, Merrett, Lisa, Morrison, Hal R I, Parke, Charlotte, Payne, Lawrence, Payne, Craig, Pike, Alexander, Seal, Aaron J, Senior, Keenan M, Smith, Kamile, Stanelyte, Joe, Stillibrand, Rachel, Szpara, Freya F H, Taday, Antony M, Threadgould, Rohan J, Trainor, Jordan, Waters, Oliver, Williams, Carrie K W, Wong, Katherine, Wood, Nick, Barton, Anna, Gruszka, Zoe, Henley, James E, Rowedder, Rosa, Cookson, Katherine L, Jones, Alan, Nadin, Ian E, Smith, Simon J F, Macdonald, Andrew, Nortcliffe
Publikováno v:
Journal of medicinal chemistry. 62(22)
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the thienopyrimidine scaffold, we have identified a liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fdc25e5b8f8a8c4bddd4753118b0c5e
https://pubmed.ncbi.nlm.nih.gov/31647659
https://pubmed.ncbi.nlm.nih.gov/31647659
Autor:
Andrew Nortcliffe, Marilia S. Santos, Christopher J. Moody, Tracey D. Bradshaw, William Lewis
Publikováno v:
Chemistry - A European Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc6c9f236bcaedfc3f64396dd0b3774a
https://doi.org/10.1002/chem.201883365
https://doi.org/10.1002/chem.201883365