Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Andrew, Bruening"'
Autor:
Servane Lachize, Carlos A. Obejero-Paz, Shushant Jain, Tiffany Snow, Andrew Bruening-Wright, Peter Hawryluk
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106815
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::101dc857bae03531a7a10ecffbd5cf75
https://doi.org/10.1016/j.vascn.2020.106815
https://doi.org/10.1016/j.vascn.2020.106815
Publikováno v:
Biophysical Journal. 114:623a-624a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d71c0df50de8558c8bacb2961e01339
https://doi.org/10.1016/j.bpj.2017.11.3371
https://doi.org/10.1016/j.bpj.2017.11.3371
Autor:
Brian Roche, Jennifer Shaffer, Carlos A. Obejero-Paz, Michelle Waines, John Ross, Andrew Bruening-Wright
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e023835614f25d3c77cbfaf3a0d76400
https://doi.org/10.1016/j.vascn.2019.05.135
https://doi.org/10.1016/j.vascn.2019.05.135
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94a09a2ef796662c4628dead69914b36
https://doi.org/10.1016/j.vascn.2019.05.035
https://doi.org/10.1016/j.vascn.2019.05.035
Publikováno v:
Biophysical Journal. 110(3)
The effect of drugs on the extracellular field potential of stem cell cardiomyocytes is one of the three components of the new Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative promoted by the FDA to assess the proarrhythmic potential of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db7c72af56efa44cf8fb693a8068f0a
Autor:
Carlos A. Obejero-Paz, James Kramer, Brian M. Roche, Andrew Bruening-Wright, John Ross, Michelle Waines
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3bc2ee076f5d3f5c7b3dfd9834cf489
https://doi.org/10.1016/j.vascn.2018.01.405
https://doi.org/10.1016/j.vascn.2018.01.405
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 61:277-286
Introduction The cardiac action potential (CAP) of stem cell-derived human cardiomyocytes (SC-hCMs) is potentially the most powerful preclinical biomarker for cardiac safety and efficacy in humans. Our experiments tested this hypothesis by examining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11d6628b961706e4575ed9e616a185f
https://doi.org/10.1016/j.vascn.2010.01.014
https://doi.org/10.1016/j.vascn.2010.01.014
Publikováno v:
The Journal of General Physiology
Small conductance calcium-gated potassium (SK) channels share an overall topology with voltage-gated potassium (K(v)) channels, but are distinct in that they are gated solely by calcium (Ca(2+)), not voltage. For K(v) channels there is strong evidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042a29bc0ae42d874ec3018b29f9643c
https://doi.org/10.1085/jgp.200709828
https://doi.org/10.1085/jgp.200709828
Publikováno v:
The Journal of Neuroscience. 27:270-278
Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels are activated by hyperpolarizations that cause inward movements of the positive charges in the fourth transmembrane domain (S4), which triggers channel opening. If HCN channels are he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679183b0f1305b6f3a88d962f8b94b80
https://doi.org/10.1523/jneurosci.3801-06.2007
https://doi.org/10.1523/jneurosci.3801-06.2007
Autor:
Arthur M. Brown, James Kramer, Peter Hawryluk, Howard C. Dittrich, Milos Tatalovic, Carlos A. Obejero-Paz, Andrew Bruening-Wright
Publikováno v:
Scientific Reports
Vanoxerine has been in clinical trials for Parkinsonism, depression and cocaine addiction but lacked efficacy. Although a potent blocker of hERG, it produced no serious adverse events. We attributed the unexpected result to offsetting Multiple Ion Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967d1410d7c4a03dc5de2777b638dc06
http://europepmc.org/articles/PMC4663487
http://europepmc.org/articles/PMC4663487