Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrew, Boudreau"'
Autor:
Lawrence Fong, Serena Kwek, Rong Deng, Yuping Li, Kevin Dang, Giulia Castello, Starlynn C Clarke, Aarti Balasubramani, Andrew Boudreau, Laura Davison, Katherine E Harris, Duy Pham, Preethi Sankaran, Harshad S Ugamraj, Alec Starzinski, Suhasini Iyer, Wim van Schooten, Ute Schellenberger, Wenchao Sun, Nathan D Trinklein, Roland Buelow, Ben Buelow, Pranjali Dalvi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Therapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents an urgent
Externí odkaz:
https://doaj.org/article/b008929f34b84d778350eb4e4a7bcce4
Autor:
Starlynn C. Clarke, Biao Ma, Nathan D. Trinklein, Ute Schellenberger, Michael J. Osborn, Laure-Hélène Ouisse, Andrew Boudreau, Laura M. Davison, Katherine E. Harris, Harshad S. Ugamraj, Aarti Balasubramani, Kevin H. Dang, Brett Jorgensen, Heather Anne N. Ogana, Duy T. Pham, Payal P. Pratap, Preethi Sankaran, Ignacio Anegon, Wim C. van Schooten, Marianne Brüggemann, Roland Buelow, Shelley Force Aldred
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based bi
Externí odkaz:
https://doaj.org/article/6a706cdfcb4649ab82279f4b31c5c13b
Autor:
Katherine E. Harris, Shelley Force Aldred, Laura M. Davison, Heather Anne N. Ogana, Andrew Boudreau, Marianne Brüggemann, Michael Osborn, Biao Ma, Benjamin Buelow, Starlynn C. Clarke, Kevin H. Dang, Suhasini Iyer, Brett Jorgensen, Duy T. Pham, Payal P. Pratap, Udaya S. Rangaswamy, Ute Schellenberger, Wim C. van Schooten, Harshad S. Ugamraj, Omid Vafa, Roland Buelow, Nathan D. Trinklein
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique syst
Externí odkaz:
https://doaj.org/article/0e55864017b746d182977ff0f5e8bf28
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
Autor:
Harshad Ugamraj, Shelley Force Aldred, Katherine E. Harris, Suhasini Iyer, Brett Jorgensen, Payal Pratap, Ute Schellenberger, Kevin Dang, Nathan D. Trinklein, Omid Vafa, Starlynn Clarke, Udaya Rangaswamy, Duy Pham, Andrew Boudreau, Arun P. Wiita, Wim Van Schooten, Roland Buelow, Ben Buelow, Priya Choudhry
Publikováno v:
mAbs
T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing activity in humans, but cytokine release-related toxicities have affected their clinical utility. The use of novel anti-CD3 binding domains with more favorable properti
Autor:
Suhasini Iyer, Roland Buelow, Udaya Rangaswamy, Harbani K. Malik-Chaudhry, Kevin Dang, Katherine E. Harris, Duy Pham, Nathan D. Trinklein, Benjamin Buelow, Andrew Boudreau, Harshad Ugamraj, Brett Jorgensen, Wim Van Schooten, Heather Ogana, Laura Davison, Ute Schellenberger, Kirthana Prabhakar
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The therapeutic potential of targeting CD19 in B cell malignancies has garnered attention in the past decade, resulting in the introduction of novel immunotherapy agents. Encouraging clinical data have been reported for T cell-based targeting agents,
Autor:
Suhasini Iyer, Kaitlyn Loughlin, Andrew Boudreau, Dennis M. Ho, Laura Davison, Preethi Sankaran, Udaya Rangaswamy, Sharon Hartstein, Nicole S. Allen, Brian Avanzino, Harbani Kaur Malik-Chaudhry, Aarti Balasubramani, Ute Schellenberger, Karen Chang, Roland Buelow, Maria-Cristina Cuturi, Nathan D. Trinklein, Harish Medlari Basappa, Ghenima Ahmil, Kyle J. Lorentsen, Katherine E. Harris
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The use of recombinant interleukin-2 (IL-2) as a therapeutic protein has been limited by significant toxicities despite its demonstrated ability to induce durable tumor-regression in cancer patients. The adverse events and limited efficacy of IL-2 tr
Autor:
Laura Davison, Suhasini Iyer, Roland Buelow, Rong Deng, Alec Starzinski, Wenchao Sun, Preethi Sankaran, Serena S. Kwek, Starlynn Clarke, Yuping Li, Nathan D. Trinklein, Lawrence Fong, Aarti Balasubramani, Pranjali Dalvi, Ute Schellenberger, Ben Buelow, Wim Van Schooten, Giulia Castello, Duy Pham, Andrew Boudreau, Harshad Ugamraj, Katherine E. Harris, Kevin Dang
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
BackgroundTherapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents an urgent
Autor:
Aarti Balasubramani, Ute Schellenberger, Harshad Ugamraj, Suhasini Iyer, Nathan D. Trinklein, Laura Davison, Brian Avanzino, Sharon Hartstein, Ben Buelow, Andrew Boudreau, Sowmya Saiganesh, Priya Ganesan, Duy Pham, Udaya Rangaswamy, Kirthana Prabhakar, Hannes Kehm, Harbani K. Malik-Chaudhry, Katherine E. Harris
Publikováno v:
Journal of Clinical Oncology. 38:e18050-e18050
e18050 Background: Ovarian Cancer (OvCa) is the leading cause of gynecologic cancer mortality in women. Since the introduction of platinum-based chemotherapy there has been little change in the prognosis of OvCa patients, with < 30% overall survival
Autor:
Laura Davison, Udaya Rangaswamy, Katherine M. Harris, Harshad Ugamraj, Ben Buelow, Duy Pham, Brett Jorgensen, Shelley Force Aldred, Aarti Balasubramani, Nathan D. Trinklein, Ute Schellenberger, Kevin Dang, Kirthana Prabhakar, Harbani Malik, Andrew Boudreau, Wim Van Schooten, Suhasini Iyer
Publikováno v:
Blood. 134:4070-4070
Introduction The restricted expression of CD19 in the B-cell lineage makes it an attractive target for the therapeutic treatment of B-cell malignancies. Many monoclonal antibodies and antibody drug conjugates targeting CD19 have been developed, inclu
Autor:
Laura Davison, Starlynn Clarke, Michael J. Osborn, Andrew Boudreau, Kevin Dang, Katherine E. Harris, Biao Ma, Ute Schellenberger, Heather Ogana, Omid Vafa, Nathan D. Trinklein, Roland Buelow, Marianne Brüggemann, Wim Van Schooten, Payal Pratap, Duy Pham, Brett Jorgensen, Benjamin Buelow, Harshad Ugamraj, Shelley Force Aldred, Udaya Rangaswamy, Suhasini Iyer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique syst