Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Andrew, Bloecher"'
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
Legend for raw response data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17345ab8b8dcb979c0e14049be5a3ed3
https://doi.org/10.1158/1535-7163.22503130
https://doi.org/10.1158/1535-7163.22503130
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
raw combination response data; response is represented as fractional viability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e7b4ed58563afddecfe4b34e5c8724
https://doi.org/10.1158/1535-7163.22503133
https://doi.org/10.1158/1535-7163.22503133
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
Supplementary figure, table and data legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462d5da00a1ff6efad42d8684cfdb08a
https://doi.org/10.1158/1535-7163.22503118
https://doi.org/10.1158/1535-7163.22503118
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
We ran 8 titration point curves (shown in gray) and then picked 4 concentration points that cover best the response curve for all cell lines (shown in red). The first point is the top plateau, the last is the bottom plateau and the other 2 are in bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862f8c6540eb40e57d14a4dea52aef8d
https://doi.org/10.1158/1535-7163.22503121.v1
https://doi.org/10.1158/1535-7163.22503121.v1
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
raw single agent response data; response is represented as fractional viability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e031cb4d261fcd6e26d648bb72c3cb6
https://doi.org/10.1158/1535-7163.22503127.v1
https://doi.org/10.1158/1535-7163.22503127.v1
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
Hierarchical clustering was performed on the response data across the cell line panel to the single agent treatments. Drugs with similar mechanisms of action clustered together.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81be606582d3fac41ce63bfe6170eb3b
https://doi.org/10.1158/1535-7163.22503124.v1
https://doi.org/10.1158/1535-7163.22503124.v1
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
RAS mutation/signature does not predict response to mTOR/Wee1 combination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad3fa32b2e0aa96bdf6bf82d7a0e736
https://doi.org/10.1158/1535-7163.22503139.v1
https://doi.org/10.1158/1535-7163.22503139.v1
Autor:
David Longmire, Haley Woods, Phillip B Rawlins, Jessie Hao-Ru Hsu, Daniel H O' Donovan, Alexandra Borodovsky, Peng Wang, Sharan K Bagal, Shaun M Fillery, Peter Barton, Clare Gregson, Beth Williamson, Samuel C Nash, Andrew Pike, Jon A Read, Kurt Gordon Pike, Andrew Bloecher, Erin Code, Minhui Shen, Sameer Kawatkar, Youfeng Nai, Jia Tang, Chengzhi Li, James C. Robinson
Publikováno v:
Journal of Medicinal Chemistry. 64:17146-17183
Aberrant activity of the histone methyltransferase polycomb repressive complex 2 (PRC2) has been linked to several cancers, with small-molecule inhibitors of the catalytic subunit of the PRC2 enhancer of zeste homologue 2 (EZH2) being recently approv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbef686d9310c0393124b8f8df7ca38
https://doi.org/10.1021/acs.jmedchem.1c01161
https://doi.org/10.1021/acs.jmedchem.1c01161
Autor:
Jennifer H. Pink, James S. Scott, Nicola Lindsay, Alan Rosen, Andrew Bloecher, Yafeng Xue, Lisa Drew, Sébastien L. Degorce, Graeme R. Robb, Christopher Thomas Halsall, Rana Anjum, Eva M. Lenz, Rodrigo J. Carbajo, Keith Dillman, Michele Mayo
Publikováno v:
Journal of Medicinal Chemistry. 62:9918-9930
In this article, we report the discovery of a series of 5-azaquinazolines as selective IRAK4 inhibitors. From modestly potent quinazoline 4, we introduced a 5-aza substitution to mask the 4-NH hydrogen bond donor (HBD). This allowed us to substitute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd9bcc98a875ec7b6d96417a1d726e0
https://doi.org/10.1021/acs.jmedchem.9b01346
https://doi.org/10.1021/acs.jmedchem.9b01346
Autor:
Yanjun Wang, Philip B. Rawlins, S. Bagal, Laura Prickett, James Robinson, Andrew Bloecher, Minhui Shen, Alan Rosen, Haley Woods, Maryann San Martin, Erin Code, Jessie Hao-Ru Hsu, Sasha Borodovsky
Publikováno v:
Blood. 138:2274-2274
The polycomb repressive complex 2(PRC2), consisting of the core subunits EED, EZH2, and SUZ12, is frequently overexpressed and deregulated in hematological and solid malignancies. Clinical validation for targeting the PRC2 complex has been demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917f296a58efdecb5ca35b19122f985f
https://doi.org/10.1182/blood-2021-150483
https://doi.org/10.1182/blood-2021-150483