Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Andreu Viader"'
Autor:
Nadine Daou, Andreu Viader, Murat Cokol, Arianna Nitzel, Manu V. Chakravarthy, Raffi Afeyan, Tony Tramontin, Svetlana Marukian, Michael J. Hamill
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Nonalcoholic steatohepatitis (NASH) is a complex metabolic disease of heterogeneous and multifactorial pathogenesis that may benefit from coordinated multitargeted interventions. Endogenous metabolic modulators (EMMs) encompass a broad set o
Externí odkaz:
https://doaj.org/article/c2f374aab92a482f9c189e152af4110d
Autor:
Andreu Viader, Jacqueline L. Blankman, Peng Zhong, Xiaojie Liu, Joel E. Schlosburg, Christopher M. Joslyn, Qing-Song Liu, Aaron J. Tomarchio, Aron H. Lichtman, Dana E. Selley, Laura J. Sim-Selley, Benjamin F. Cravatt
Publikováno v:
Cell Reports, Vol 12, Iss 5, Pp 798-808 (2015)
The endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior. 2-AG signaling is terminated by enzymatic hydrolysis—a reaction that is principally performed by mono
Externí odkaz:
https://doaj.org/article/a58d2651f0fd4eff8581e58600acdec0
Autor:
Andreu Viader, Daisuke Ogasawara, Christopher M Joslyn, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Benjamin F Cravatt
Publikováno v:
eLife, Vol 5 (2016)
Metabolic specialization among major brain cell types is central to nervous system function and determined in large part by the cellular distribution of enzymes. Serine hydrolases are a diverse enzyme class that plays fundamental roles in CNS metabol
Externí odkaz:
https://doaj.org/article/d5e645537bb8498db55da5346fdc087b
Autor:
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Gianluca Moroncini, Andreu Viader, Daniel K Nomura, Benjamin F Cravatt, Bruno Conti
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134437 (2015)
Cyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE2). Historically, phospholipases have been considered to be the primary genera
Externí odkaz:
https://doaj.org/article/7714e688c11e4794b6fb2eccd4f6981b
Autor:
Andreu Viader, Elizabeth C Wright-Jin, Bhupinder P S Vohra, Robert O Heuckeroth, Jeffrey Milbrandt
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27727 (2011)
Mitochondrial dysfunction is a central mediator of disease progression in diverse neurodegenerative diseases that often present with prominent gastrointestinal abnormalities. Gastrointestinal dysfunction in these disorders is related, at least in par
Externí odkaz:
https://doaj.org/article/7252d12d1e9d49fabe41dfe7733e5200
Autor:
Heike Wobst, Ryan Hollibaugh, Giovanni Muncipinto, Christopher Burkhart, Daniel van Kalken, Andreu Viader, Heather Blanchette, Dean Brown, Nick Pullen, John Throup, Joel Barrish
Publikováno v:
Molecular Genetics and Metabolism. 138:107502
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e27d4c556d321df361eaf7d97318ebb7
https://doi.org/10.1016/j.ymgme.2023.107502
https://doi.org/10.1016/j.ymgme.2023.107502
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2006 Jun . 103(25), 9685-9690.
Externí odkaz:
https://www.jstor.org/stable/30050969
Autor:
Svetlana Marukian, Michael Hamill, Tony Tramontin, Murat Cokol, Arianna Nitzel, Manu V. Chakravarthy, Raffi Afeyan, Daou Nadine, Andreu Viader
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Nonalcoholic steatohepatitis (NASH) is a complex metabolic disease of heterogeneous and multifactorial pathogenesis that may benefit from coordinated multitargeted interventions. Endogenous metabolic modulators (EMMs) encompass a broad set of molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08635b467e1ffe258aeea39e8c43667
https://doi.org/10.1038/s41598-021-88913-1
https://doi.org/10.1038/s41598-021-88913-1
Autor:
Leyuan Bao, Jacqueline L. Blankman, Tim Ambrose, Olesya Ulanovskaya, Alan Ezekowitz, Gary P. O'Neill, Andreu Viader, Alison Simmons
Publikováno v:
SSRN Electronic Journal.
Monoacylglycerol lipase (MGLL) is a serine hydrolase required for the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2AG) to downstream eicosanoids. 2AG has been shown to modulate immune cell function but its role in human primary innate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e9792bbd5ffed8874d8b88b34602a8
https://doi.org/10.2139/ssrn.3707262
https://doi.org/10.2139/ssrn.3707262
Autor:
Gabriel M. Simon, Cheryl A. Grice, Micah J. Niphakis, Olivia D. Weber, R. Alan B. Ezekowitz, Nhi Ngo, Rachel A. Herbst, Jason R. Clapper, Justin S. Cisar, Iain P. Fraser, Jacqueline L. Blankman, Dylan M. Herbst, Mark L. Cunningham, Gary P. O'Neill, Todd K. Jones, Anna M. Knize, Alex Reed, Cassandra L. Henry, Aundrea R. Coppola, Andreu Viader, Jessica P. Alexander
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(3)
Monoacylglycerol lipase (MGLL) is the primary degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). The first MGLL inhibitors have recently entered clinical development for the treatment of neurologic disorders. To support this cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef38160293a49bd7fff58ad8eba72dc0
https://pubmed.ncbi.nlm.nih.gov/30305428
https://pubmed.ncbi.nlm.nih.gov/30305428