Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Autor:
Shingo Bessho, Kaitlyn C. M. Grando, Kathrine Kyrylchuk, Amanda Miller, Andres J. Klein-Szanto, Wenhan Zhu, Stefania Gallucci, Vincent Tam, Çagla Tükel
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe Salmonella biofilm-associated amyloid protein, curli, is a dominant instigator of systemic inflammation and autoimmune responses following Salmonella infection. Systemic curli injections or infection of mice with Salmonella Typhimurium in
Externí odkaz:
https://doaj.org/article/188e20a58d6241adb0debc0e1f35d22a
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
Annie D. Fuller, Adam L. Karami, Mohammad Faujul Kabir, Alena Klochkova, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Andres J. Klein-Szanto, Kelly A. Whelan
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
IntroductionUnder homeostatic conditions, esophageal epithelium displays a proliferation/differentiation gradient that is generated as proliferative basal cells give rise to suprabasal cells then terminally differentiated superficial cells. This prol
Externí odkaz:
https://doaj.org/article/bfa60c20b4244bd9b9ed3cd95ddddc6d
Autor:
Alena Klochkova, Annie D. Fuller, Riley Miller, Adam L. Karami, Surali R. Panchani, Shruthi Natarajan, Anbin Mu, Jazmyne L. Jackson, Andres J. Klein-Szanto, Amanda B. Muir, Kelly A. Whelan
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Subepithelial fibrosis occurs in a subset of eosinophilic esophagitis (EoE) patients and is associated with esophageal stricture. While mechanisms driving EoE fibrosis remain incompletely understood, findings from experimental systems support roles f
Externí odkaz:
https://doaj.org/article/70fd8a55c4ad44cc9bb32754ad67cee8
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell
Externí odkaz:
https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/515147b47c8045f7a83bb33af1989d17
Autor:
Kensuke Suzuki, Yasunori Masuike, Rei Mizuno, Uma M. Sachdeva, Priya Chatterji, Sarah F. Andres, Wenping Sun, Andres J. Klein-Szanto, Sepideh Besharati, Helen E. Remotti, Michael P. Verzi, Anil K. Rustgi
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Externí odkaz:
https://doaj.org/article/83ff55ab14b94dd0b2d998b9172249d6
Autor:
Karen J. Dunbar, Tatiana A. Karakasheva, Qiaosi Tang, Gizem Efe, Eric W. Lin, Michael Harris, Varun Sahu, Uma M. Sachdeva, Jianhua Hu, Andres J. Klein-Szanto, Brian Henick, J. Alan Diehl, Hiroshi Nakagawa, Anil K. Rustgi
Publikováno v:
Molecular Cancer Research. :OF1-OF12
Cancer-associated fibroblasts (CAF) can promote tumor growth, metastasis, and therapeutic resistance in esophageal squamous cell carcinoma (ESCC), but the mechanisms of action remain elusive. Our objective was to identify secreted factor(s) that medi
Autor:
Mohammad Faujul Kabir, Jazmyne L Jackson, Annie D Fuller, Leonny Gathuka, Adam L Karami, Don-Gerard Conde, Alena Klochkova, Anbin Mu, Kathy Q Cai, Andres J Klein-Szanto, Amanda B Muir, Kelly A Whelan
Publikováno v:
Carcinogenesis. 44:182-195
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of human malignancy, often displaying limited therapeutic response. Here, we examine the non-steroidal anti-inflammatory drug diclofenac (DCF) as a novel therapeutic agent