Zobrazeno 1 - 10
of 385
pro vyhledávání: '"Andres J Klein-Szanto"'
Autor:
Prasanna M Chandramouleeswaran, Manti Guha, Masataka Shimonosono, Kelly A Whelan, Hisatsugu Maekawa, Uma M Sachdeva, Gordon Ruthel, Sarmistha Mukherjee, Noah Engel, Michael V Gonzalez, James Garifallou, Shinya Ohashi, Andres J Klein-Szanto, Clementina A Mesaros, Ian A Blair, Renata Pellegrino da Silva, Hakon Hakonarson, Eishi Noguchi, Joseph A Baur, Hiroshi Nakagawa
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While
Externí odkaz:
https://doaj.org/article/5a4df4b8798b4fd795ef2f8d80b295c8
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33116 (2012)
Epithelial-mesenchymal transition (EMT) is a crucial step for the acquisition of invasive properties of carcinoma cells during tumor progression. Epidermal growth factor (EGF)-treatment of squamous cell carcinoma (SCC) cells provokes changes in the e
Externí odkaz:
https://doaj.org/article/c3e1789fb91f4df9bb5cfc7010d78bfc
Autor:
Jason A Watts, Chaolin Zhang, Andres J Klein-Szanto, Jay D Kormish, Jian Fu, Michael Q Zhang, Kenneth S Zaret
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002277 (2011)
Understanding how silent genes can be competent for activation provides insight into development as well as cellular reprogramming and pathogenesis. We performed genomic location analysis of the pioneer transcription factor FoxA in the adult mouse li
Externí odkaz:
https://doaj.org/article/f87d47b1a77f49a698aae2387b23620c
Autor:
Deborah A Altomare, Craig W Menges, Jinfei Xu, Jianming Pei, Lili Zhang, Ara Tadevosyan, Erin Neumann-Domer, Zemin Liu, Michele Carbone, Ilse Chudoba, Andres J Klein-Szanto, Joseph R Testa
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18828 (2011)
The CDKN2A/ARF locus encompasses overlapping tumor suppressor genes p16(INK4A) and p14(ARF), which are frequently co-deleted in human malignant mesothelioma (MM). The importance of p16(INK4A) loss in human cancer is well established, but the relative
Externí odkaz:
https://doaj.org/article/3296af4ec9614769bb22572ce8a65167
Autor:
Kathy Qi Cai, Corrado Caslini, Callinice D Capo-chichi, Carolyn Slater, Elizabeth R Smith, Hong Wu, Andres J Klein-Szanto, Andrew K Godwin, Xiang-Xi Xu
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6454 (2009)
The family of zinc finger-containing GATA transcription factors plays critical roles in cell lineage specification during early embryonic development and organ formation. GATA4 and GATA6 were found to be frequently lost in ovarian cancer, and the los
Externí odkaz:
https://doaj.org/article/b17bd7fba9324e1ebf66cf43bb22e99f
Autor:
Jian Fu, Kathryn Fong, Alfonso Bellacosa, Eric Ross, Sinoula Apostolou, Daniel E Bassi, Fang Jin, Jirong Zhang, Paul Cairns, Inmaculada Ibañez de Caceres, Karl-Heinz Braunewell, Andres J Klein-Szanto
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1698 (2008)
VILIP-1, a member of the neuronal Ca++ sensor protein family, acts as a tumor suppressor gene in an experimental animal model by inhibiting cell proliferation, adhesion and invasiveness of squamous cell carcinoma cells. Western Blot analysis of human
Externí odkaz:
https://doaj.org/article/6205dc8587ab412ca7bcf8b1c849ebea
Autor:
Shingo Bessho, Kaitlyn C. M. Grando, Kathrine Kyrylchuk, Amanda Miller, Andres J. Klein-Szanto, Wenhan Zhu, Stefania Gallucci, Vincent Tam, Çagla Tükel
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe Salmonella biofilm-associated amyloid protein, curli, is a dominant instigator of systemic inflammation and autoimmune responses following Salmonella infection. Systemic curli injections or infection of mice with Salmonella Typhimurium in
Externí odkaz:
https://doaj.org/article/188e20a58d6241adb0debc0e1f35d22a
Autor:
Annie D. Fuller, Adam L. Karami, Mohammad Faujul Kabir, Alena Klochkova, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Andres J. Klein-Szanto, Kelly A. Whelan
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
IntroductionUnder homeostatic conditions, esophageal epithelium displays a proliferation/differentiation gradient that is generated as proliferative basal cells give rise to suprabasal cells then terminally differentiated superficial cells. This prol
Externí odkaz:
https://doaj.org/article/bfa60c20b4244bd9b9ed3cd95ddddc6d
Autor:
Alena Klochkova, Annie D. Fuller, Riley Miller, Adam L. Karami, Surali R. Panchani, Shruthi Natarajan, Anbin Mu, Jazmyne L. Jackson, Andres J. Klein-Szanto, Amanda B. Muir, Kelly A. Whelan
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Subepithelial fibrosis occurs in a subset of eosinophilic esophagitis (EoE) patients and is associated with esophageal stricture. While mechanisms driving EoE fibrosis remain incompletely understood, findings from experimental systems support roles f
Externí odkaz:
https://doaj.org/article/70fd8a55c4ad44cc9bb32754ad67cee8