The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

Autor: Fabiana Heredia, Yanel Volonté, Joana Pereirinha, Magdalena Fernandez-Acosta, Andreia P. Casimiro, Cláudia G. Belém, Filipe Viegas, Kohtaro Tanaka, Juliane Menezes, Maite Arana, Gisele A. Cardoso, André Macedo, Malwina Kotowicz, Facundo H. Prado Spalm, Marcos J. Dibo, Raquel D. Monfardini, Tatiana T. Torres, César S. Mendes, Andres Garelli, Alisson M. Gontijo

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

Pupariation in Drosophila is triggered by the steroid-hormone ecdysone and requires coordination between associated behavioral and body-reshaping motor subprograms. The authors show that coordination requires ecdysone-dependent Dilp8-Lgr3 signaling b

Externí odkaz: https://doaj.org/article/f822d3a3ff054af8a43f277e88d9af21

Retinoid X receptor activation promotes photoreceptor survival and modulates the inflammatory response in a mouse model of retinitis pigmentosa

Autor: Yanel A. Volonté, Victoria B. Ayala-Peña, Nora P. Rotstein, Olga Lorena German, Harmonie Vallese-Maurizi, Luis E. Politi, Andres Garelli

Publikováno v: Biochimica et biophysica acta. Molecular cell research. 1868(11)

Photoreceptor cell (PHR) death is a hallmark of most retinal neurodegenerative diseases, in which inflammation plays a critical role. Activation of retinoid X receptors (RXR) modulates and integrates multiple cell functions, and has beneficial effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb34d4aeb77f357bbdffceaa6122277
https://pubmed.ncbi.nlm.nih.gov/34271041

The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

Autor: Tatiana Teixeira Torres, Raquel Dietsche Monfardini, Cláudia G. Belém, Gisele Antoniazzi Cardoso, Maite Arana, Filipe Viegas, Juliane Menezes, Yanel A. Volonté, Fabiana Heredia, Andre Macedo, Magdalena Fernandez-Acosta, Andres Garelli, César S. Mendes, Marcos J. Dibo, Alisson M. Gontijo, Joana Pereirinha, Malwina Kotowicz, Kohtaro Tanaka, Andreia P. Casimiro, Facundo H. Prado Spalm

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications 12(1), 3328 (2021). doi:10.1038/s41467-021-23218-5

Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66235f71872584b5a7d55426e38ac3ff
https://pubmed.ncbi.nlm.nih.gov/34099654

Diisopropylphenyl-imidazole (DII): A new compound that exerts anthelmintic activity through novel molecular mechanisms

Autor: Maria Gabriela Blanco, Andres Garelli, Maria Jose de Rosa, Gustavo F. Silbestri, Maria Soledad Vela Gurovic, Diego Hernán Rayes, Sebastián Giunti

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0007021 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Nematode parasites cause substantial morbidity to billions of people and considerable losses in livestock and food crops. The repertoire of effective anthelmintic compounds for treating these parasitoses is very limited, as drug development has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b603990c746b90a2aee72869cc52670
http://europepmc.org/articles/PMC6312359

Trophic factors and neuronal interactions regulate the cell cycle and Pax6 expression in Müller stem cells

Autor: Luis E. Politi, Andres Garelli, M. Victoria Simón, Beatriz de los Santos, M. Fernanda Insua, Nora P. Rotstein

Publikováno v: Journal of Neuroscience Research. 86:1459-1471

The finding that Müller cells have stem cell properties in the retina has led to the hypothesis that they might be a source for replacing neurons lost in neurodegenerative diseases. However, utilization of Müller cells for regenerative purposes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0413b5fa82832d4066ba06d0ed88f40
https://doi.org/10.1002/jnr.21606