Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Andres, Digenio"'
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Akademický článek
Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results1
Autor: Xiaohong Yang, Sang-Rok Lee, Yun-Seok Choi, Veronica J. Alexander, Andres Digenio, Qingqing Yang, Yury I. Miller, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v: Journal of Lipid Research, Vol 57, Iss 4, Pp 706-713 (2016)
Elevated apoC-III levels predict increased cardiovascular risk when present on LDL and HDL particles. We developed novel high-throughput chemiluminescent ELISAs that capture apoB, lipoprotein (a) [Lp(a)], and apoA-I in plasma and then detect apoC-III
Externí odkaz: https://doaj.org/article/40bbe240a7034b35bb4e01f1c165f503
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2
Achievement of Target A1C <7.0% (<53 mmol/mol) by U.S. Type 2 Diabetes Patients Treated With Basal Insulin in Both Randomized Controlled Trials and Clinical Practice
Autor: Rong Zhou, Andres DiGenio, Mehul Dalal, Keith L. Davis, Juliana Meyers, Stephen A. Brunton, Pavan Chava, Lawrence Blonde
Publikováno v: Diabetes Spectrum : A Publication of the American Diabetes Association
Objective. Many patients with type 2 diabetes do not reach glycemic goals despite basal insulin treatment. This study assessed the achievement of a target A1C Methods. This was a retrospective analysis of pooled randomized controlled trial (RCT) data
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d7483a124753571088568edbc2689e
https://doi.org/10.2337/ds17-0082
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3
Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1BRx Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes
Autor: Lynnetta Watts, Erin S. Morgan, Nguyen C. Pham, Richard S. Geary, Sanjay Bhanot, Andres DiGenio, Shiangtung W. Jung, Brenda F. Baker
Publikováno v: Diabetes Care. 41:807-814
OBJECTIVE To evaluate safety and efficacy of IONIS-PTP-1BRx, a second-generation 2′-O-methoxyethyl antisense inhibitor of protein tyrosine phosphatase 1B, as add-on therapy in overweight patients with type 2 diabetes inadequately controlled with me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8de1a71e83819b1a2b2fda5df493cbae
https://doi.org/10.2337/dc17-2132
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4
Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles
Autor: James MacDougall, Handrean Soran, Patrick M. Moriarty, Daniel Gaudet, Brant Hubbard, John J.P. Kastelein, Veronica J. Alexander, Robert A. Hegele, Joseph L. Witztum, Andres Digenio, Marcello Arca, Louis O'Dea, Eric Bruckert
Publikováno v: Journal of the Endocrine Society, 3(12), 2397-2410. Endocrine Society
Journal of the Endocrine Society
ContextDifferentiation between familial chylomicronemia syndrome (FCS, type 1 hyperlipoproteinemia), a rare metabolic disorder, and the more common multifactorial severe hypertriglyceridemia (sHTG, type 5 hyperlipoproteinemia) is challenging because
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce32e1769c8f073581611ac61d45d255
http://hdl.handle.net/11573/1344451
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5
Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome
Autor: Louis O'Dea, Sotirios Tsimikas, Qingqing Yang, Erik S.G. Stroes, Daniel Gaudet, Fernando Civeira, Handrean Soran, Dirk J. Blom, Linda C. Hemphill, Steven D. Freedman, Jean Bergeron, Joseph L. Witztum, Steven Hughes, Richard S. Geary, Eric Bruckert, Andres Digenio, Veronica J. Alexander, Marcello Arca, Karren R Williams
Publikováno v: Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2019, 381 (6), pp.531-542. ⟨10.1056/NEJMoa1715944⟩
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
New England journal of medicine, 381(6), 531-542. Massachussetts Medical Society
Background Familial chylomicronemia syndrome is a rare genetic disorder that is caused by loss of lipoprotein lipase activity and characterized by chylomicronemia and recurrent episodes of pancreatitis. There are no effective therapies. In an open-la
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff567e3a90f9517372769b14c7843183
http://zaguan.unizar.es/record/96046
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6
ApoC-III Levels Correlate with Insulin Resistance and HbA1c in Familial Partial Lipodystrophy—Observations from the Broaden Study
Autor: Joseph Tami, Elif A. Oral, Rasimcan Meral, Andres Digenio, Adam H. Neidert
Publikováno v: Diabetes. 67
Familial Partial Lipodystrophy (FPLD) is a rare genetic disorder with selective loss of adipose tissue from the periphery with an increase in ectopic fat leading to severe hepatic insulin resistance, and hypertriglyceridemia. ApoC-III is a secreted l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::981fa0eb6ad5e1ba033901885e68424f
https://doi.org/10.2337/db18-623-p
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8
Characterizing familial chylomicronemia syndrome: Baseline data of the APPROACH study
Autor: Linda C. Hemphill, Raul D. Santos, Dirk J. Blom, Seth J. Baum, Andres Digenio, Ewa Karwatowska-Prokopczuk, Joseph L. Witztum, Ovidio Muñiz-Grijalvo, Louis O'Dea, Karren R Williams, Veronica J. Alexander
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Background Familial chylomicronemia syndrome (FCS) is a rare metabolic disorder caused by mutations in lipoprotein lipase (LPL) or genes required for LPL functionality and is characterized by hyperchylomicronemia that results in recurrent episodes of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e6c733609c82f480fc505ff6fa785f
https://pubmed.ncbi.nlm.nih.gov/30318066
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9
Fasting Versus Postprandial Hyperglycemia as a Treatment Target to Lower Elevated Hemoglobin A1C
Autor: Rong Zhou, Timothy Reid, Aleksandra Vlajnic, Charles F. Shaefer, Andres DiGenio
Publikováno v: Endocrine Practice. 21:1323-1332
Objective: Postprandial hyperglycemia (PPHG) may need addressing when glycemic control cannot be maintained in patients with type 2 diabetes mellitus. We investigated whether glycated hemoglobin A1c (A1c) levels ≥7.0% can indicate postprandial defe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5553edd6c77af9625141123c46ff1b3c
https://doi.org/10.4158/ep14498.or
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10
Type 2 diabetes mellitus treatment patterns in US nursing home residents
Autor: Carrie Allen, Mark Haumschild, Mehul Dalal, Barbara J. Zarowitz, Andres DiGenio, Terrence O'Shea
Publikováno v: Postgraduate Medicine. 127:429-437
The prevalence of type 2 diabetes mellitus (diabetes) in nursing home residents (NHRs) is increasing, concurrently with obesity and other comorbid conditions. NHR would benefit greatly from antidiabetic medications that would improve glycemic control
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea81f3c59b27ec720bb863dd643410e3
https://doi.org/10.1080/00325481.2015.1035621
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