Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Andrejs M. Krumins"'
Autor:
Andrejs M. Krumins, Alfred G. Gilman
Publikováno v:
Journal of Biological Chemistry. 281:10250-10262
Heterotrimeric G protein signaling specificity has been attributed to select combinations of Galpha, beta, and gamma subunits, their interactions with other signaling proteins, and their localization in the cell. With few exceptions, the G protein su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbe9cead9181ea32cfbfd4a2113ccd6
https://doi.org/10.1074/jbc.m511551200
https://doi.org/10.1074/jbc.m511551200
Autor:
Thomas M. Wilkie, Andrejs M. Krumins, Stephen J. Gold, Kan Yu, Susanne M. Mumby, Chunfa Huang, Roger K. Sunahara, Sheryll A. Barker
Publikováno v:
Journal of Biological Chemistry. 279:2593-2599
Regulators of G protein signaling (RGS proteins) constitute a family of newly appreciated components of G protein-mediated signal transduction. With few exceptions, most information available on mammalian RGS proteins was gained by transfection/overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d241b00275329e1555446a65fc9b95
https://doi.org/10.1074/jbc.m311600200
https://doi.org/10.1074/jbc.m311600200
Autor:
Mason R. Mackey, Marsha L. Crochiere, Sean M. Bell, Andrejs M. Krumins, Roger K. Sunahara, Susan S. Taylor, Guy Perkins, Lin Wang, Mark H. Ellisman
Publikováno v:
Proceedings of the National Academy of Sciences. 98:3220-3225
Differential compartmentalization of signaling molecules in cells and tissues is being recognized as an important mechanism for regulating the specificity of signal transduction pathways. A kinase anchoring proteins (AKAPs) direct the subcellular loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07d1288605364d7014a8d4c15039f63
https://doi.org/10.1073/pnas.051633398
https://doi.org/10.1073/pnas.051633398
Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity
Autor:
Tatsuya Ingi, Andrejs M. Krumins, Peter Chidiac, Greg M. Brothers, Stephen Chung, Bryan E. Snow, Carol A. Barnes, Anthony A. Lanahan, David P. Siderovski, Elliott M. Ross, Alfred G. Gilman, Paul F. Worley
Publikováno v:
The Journal of Neuroscience. 18:7178-7188
Long-term neuronal plasticity is known to be dependent on rapidde novosynthesis of mRNA and protein, and recent studies provide insight into the molecules involved in this response. Here, we demonstrate that mRNA encoding a member of the regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca058f8b4451471473a764df2584e29
https://doi.org/10.1523/jneurosci.18-18-07178.1998
https://doi.org/10.1523/jneurosci.18-18-07178.1998
Autor:
Bryan E. Snow, Randy A. Hall, Andrejs M. Krumins, Greg M. Brothers, Denis Bouchard, Carol Anne Brothers, Stephen Chung, Joan Mangion, Alfred G. Gilman, Robert J. Lefkowitz, David P. Siderovski
Publikováno v:
Journal of Biological Chemistry. 273:17749-17755
Regulator of G-protein signaling (RGS) proteins increase the intrinsic guanosine triphosphatase (GTPase) activity of G-protein alpha subunits in vitro, but how specific G-protein-coupled receptor systems are targeted for down-regulation by RGS protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f0a6d652bd0ac7d931e7d93f0ddb14
https://doi.org/10.1074/jbc.273.28.17749
https://doi.org/10.1074/jbc.273.28.17749
Autor:
Roger Barber, Andrejs M. Krumins
Publikováno v:
Molecular Pharmacology. 52:144-154
A restricted version of the ternary complex model for receptor-G protein complex formation has recently been proposed. Known as the two-state model, this model proposes that in the context of agonist and G protein interactions, only two thermodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088ced1375bdf991cf0c2e341da5641f
https://doi.org/10.1124/mol.52.1.144
https://doi.org/10.1124/mol.52.1.144
Publikováno v:
The Journal of biological chemistry. 278(10)
The activation of heterotrimeric G proteins is accomplished primarily by the guanine nucleotide exchange activity of ligand-bound G protein-coupled receptors. The existence of nonreceptor guanine nucleotide exchange factors for G proteins has also be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dee3256e33f73930f92fb9a4de0647
https://pubmed.ncbi.nlm.nih.gov/12509430
https://pubmed.ncbi.nlm.nih.gov/12509430
Autor:
Shelley B. Hooks, Erik T. Bodor, Andrejs M. Krumins, James Corbitt, T. Kendall Harden, G L Waldo
Regulator of G-protein signaling (RGS) proteins are GTPase activating proteins (GAPs) of heterotrimeric G-proteins that alter the amplitude and kinetics of receptor-promoted signaling. In this study we defined the G-protein alpha-subunit selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b90474507dc637102b4363f98b022e
Autor:
Andrejs M, Krumins, Alfred G, Gilman
Publikováno v:
Methods in enzymology. 344
Single-turnover and steady-state GTPase assays are an effective means to identify and characterize interactions between RGS and G alpha proteins in vitro. The advantage of the single turnover GTPase assay is that it permits simple and rapid assessmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::451434528ffbd5b27e281995eec34f3c
https://pubmed.ncbi.nlm.nih.gov/11771419
https://pubmed.ncbi.nlm.nih.gov/11771419
Autor:
Alfred G. Gilman, Andrejs M. Krumins
Single-turnover and steady-state GTPase assays are an effective means to identify and characterize interactions between RGS and G alpha proteins in vitro. The advantage of the single turnover GTPase assay is that it permits simple and rapid assessmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2692475cc3bba929045ea9ebc1a6c5ee
https://doi.org/10.1016/s0076-6879(02)44748-9
https://doi.org/10.1016/s0076-6879(02)44748-9