An ATP Binding Cassette Transporter Mediates the Uptake of α-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates

Autor: Folmer Fredslund, Tom Andersen, Birte Svensson, Joakim Mark Andersen, Dirk Jan Slotboom, Jonas Rosager Henriksen, Maher Abou Hachem, Morten Ejby, Andreja Vujičić Žagar

Publikováno v: Hansen, M E, Fredslund, F, Andersen, J M, Žagar, A V, Henriksen, J R, Andresen, T L, Svensson, B, Slotboom, D J & Abou Hachem, M 2016, ' An ATP Binding Cassette Transporter Mediates the Uptake of α-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates ', Journal of Biological Chemistry, vol. 291, no. 38, pp. 20220-20231 . https://doi.org/10.1074/jbc.M116.746529
The Journal of Biological Chemistry, 291(38), 20220-20231. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

The molecular details and impact of oligosaccharide uptake by distinct human gut microbiota (HGM) are currently not well understood. Non-digestible dietary galacto- and gluco--(1,6)-oligosaccharides from legumes and starch, respectively, are preferen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809254ad8de1543e8ca2ff50fa58d8cc
https://doi.org/10.1074/jbc.m116.746529

Structure of the α-1,6/α-1,4-specific glucansucrase GTFA fromLactobacillus reuteri121

Autor: Lubbert Dijkhuizen, Andreja Vujičić-Žagar, Bauke W. Dijkstra, Slavko Kralj, Tjaard Pijning

Publikováno v: Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68(12), 1448-1454

The reuteransucrase GTFA from Lactobacillus reuteri 121, which belongs to glycosyl hydrolase family GH70, synthesizes branched alpha-glucans with both alpha-1,6-and alpha-1,4-glycosidic linkages (reuteran) from sucrose. The crystal structure of GTFA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7776c9826f34bfd37bb670f52c69134
https://doi.org/10.1107/s1744309112044168

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module

Autor: Oscar Vadas, Leonardo Scapozza, Federico Gulluni, Andreja Vujičić Žagar, Volker Haucke, Martin Lehmann, Wen-Ting Lo, Haibin Wang

Publikováno v: Molecular Cell, Vol. 71, No 2 (2018) pp. 343-351.e4

Class II phosphoinositide 3-kinases (PI3K-C2) are large multidomain enzymes that control cellular functions ranging from membrane dynamics to cell signaling via synthesis of 3'-phosphorylated phosphoinositides. Activity of the alpha isoform (PI3K-C2�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fbcd11e06e50e87cd9411989161a3f
https://doi.org/10.1016/j.molcel.2018.06.042

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch

Autor: Dymtro Puchkov, Oxana Krylova, Andreja Vujičić Žagar, Martin Lehmann, Wen-Ting Lo, Christian Freund, Fabian Gerth, Oscar Vadas, Leonardo Scapozza, Volker Haucke

Publikováno v: Developmental Cell. 43:522-529.e4

Clathrin-mediated endocytosis occurs by bending and remodeling of the membrane underneath the coat. Bin-amphiphysin-rvs (BAR) domain proteins are crucial for endocytic membrane remodeling, but how their activity is spatiotemporally controlled is larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53fa90aa8486022610ae67e73d86013
https://doi.org/10.1016/j.devcel.2017.10.019