Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Andrej Kovac"'
Autor:
Ivana Gerhardtova, Ivana Cizmarova, Timotej Jankech, Dominika Olesova, Josef Jampilek, Vojtech Parrak, Kristina Nemergutova, Ladislav Sopko, Juraj Piestansky, Andrej Kovac
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 753 (2024)
Nowadays, lipidomics plays a crucial role in the investigation of novel biomarkers of various diseases. Its implementation into the field of clinical analysis led to the identification of specific lipids and/or significant changes in their plasma lev
Externí odkaz:
https://doaj.org/article/54a097b7e4d64de8af3d6ab815d58a3d
Autor:
Ivana Cizmarova, Vojtech Parrak, Peter Secnik jr, Peter Secnik, Ladislav Sopko, Kristina Nemergutova, Andrej Kovac, Peter Mikus, Juraj Piestansky
Publikováno v:
Heliyon, Vol 9, Iss 12, Pp e23111- (2023)
Colistin and other polymyxin antibiotics have become increasingly used in clinical settings as a result of treating multidrug-resistant infections in critically ill patients. The highly variable pharmacokinetics of colistin in these patients is accom
Externí odkaz:
https://doaj.org/article/48ab71ed106544b4af073c360623a4f3
Autor:
Timotej Jankech, Ivana Gerhardtova, Petra Majerova, Juraj Piestansky, Lubica Fialova, Josef Jampilek, Andrej Kovac
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1003 (2024)
Many biologically active metabolites of the essential amino acid L-tryptophan (Trp) are associated with different neurodegenerative diseases and neurological disorders. Precise and reliable methods for their determination are needed. Variability in t
Externí odkaz:
https://doaj.org/article/f37c7e63e1214a8ba6b47b5cf8b540a9
Autor:
Petra Majerova, Dominika Olesova, Greta Golisova, Martina Buralova, Alena Michalicova, Jozef Vegh, Juraj Piestansky, Mangesh Bhide, Jozef Hanes, Andrej Kovac
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113257- (2022)
Kynurenines have immunomodulatory and neuroactive properties and can influence the central nervous system. Previous studies showed the involvement of the kynurenines in the pathogenesis and progression of neurodegenerative disease. In neurodegenerati
Externí odkaz:
https://doaj.org/article/fb958a2bf4934150abe13c9c0346c4b3
Autor:
Branislav Kovacech, Lubica Fialova, Peter Filipcik, Rostislav Skrabana, Monika Zilkova, Natalia Paulenka-Ivanovova, Andrej Kovac, Denisa Palova, Gabriela Paulikova Rolkova, Katarina Tomkova, Natalia Turic Csokova, Karina Markova, Michaela Skrabanova, Kristina Sinska, Neha Basheer, Petra Majerova, Jozef Hanes, Vojtech Parrak, Michal Prcina, Ondrej Cehlar, Martin Cente, Juraj Piestansky, Michal Fresser, Michal Novak, Monika Slavikova, Kristina Borsova, Viktoria Cabanova, Bronislava Brejova, Tomas Vinař, Jozef Nosek, Boris Klempa, Ludek Eyer, Vaclav Hönig, Martin Palus, Daniel Ruzek, Tereza Vyhlidalova, Petra Strakova, Blanka Mrazkova, Dagmar Zudova, Gizela Koubkova, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek, Norbert Zilka, Eva Kontsekova
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103818- (2022)
Summary: Background: The emergence of new SARS-CoV-2 variants of concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) that harbor mutations in the viral S protein raised concern about activity of current vaccines and therapeutic
Externí odkaz:
https://doaj.org/article/d503988bb92a4f8ca2f39b041da95550
Autor:
Petra Majerova, Dominika Pindjakova, Timotej Jankech, Ivana Gerhardtova, Jiri Kos, Andrej Kovac, Josef Jampilek
Publikováno v:
Chemistry Proceedings, Vol 12, Iss 1, p 40 (2022)
Recently, a series of thirty-eight 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides designed as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors were described as potential drugs to alleviate the symptoms of Alzheimer’s
Externí odkaz:
https://doaj.org/article/63feeee88f5c498fad00d24b642defb1
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-18 (2019)
Abstract Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics. One of the methods usually used for
Externí odkaz:
https://doaj.org/article/8eaf806bb80347a9a79418319bcf6ce8
Autor:
Patrik Simko, Andrea Leskanicova, Maria Suvakova, Alzbeta Blicharova, Martina Karasova, Michal Goga, Mariana Kolesarova, Bianka Bojkova, Petra Majerova, Nela Zidekova, Ivan Barvik, Andrej Kovac, Terezia Kiskova
Publikováno v:
Life, Vol 12, Iss 7, p 1090 (2022)
Atranorin (ATR) is a secondary metabolite of lichens. While previous studies investigated the effects of this substance predominantly in an in vitro environment, in our study we investigated the basic physicochemical properties, the binding affinity
Externí odkaz:
https://doaj.org/article/da584f4e250949708dd970c59dfefd11
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The blood–brain barrier (BBB) plays a crucial role in maintaining the specialized microenvironment of the central nervous system (CNS). In aging, the stability of the BBB declines and the permeability increases. The list of CNS pathologies involvin
Externí odkaz:
https://doaj.org/article/482833e227aa41f9a0cfa097ab9e653f
Autor:
Juraj Piestansky, Andrea Forgacsova, Dominika Olesova, Jaroslav Galba, Peter Mikus, Petra Majerova, Andrej Kovac
Publikováno v:
Separations, Vol 9, Iss 1, p 16 (2022)
Neurotransmitters (NT) are widely distributed in the central nervous system. These molecules are important for many physiological processes and the function of the immune system. Imbalance of NT are linked to numerous neurological disorders and disea
Externí odkaz:
https://doaj.org/article/d5b043a8b0994318a4b6577198c951be