Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrej J. Savol"'
Autor:
Andrej J Savol, Peggy I Wang, Yesu Jeon, David Colognori, Eda Yildirim, Stefan F Pinter, Bernhard Payer, Jeannie T Lee, Ruslan I Sadreyev
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182568 (2017)
In mammals, monoallelic gene expression can result from X-chromosome inactivation, genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation of RMAE is not fully understood. Here we analyze allelic imbalance in chromatin sta
Externí odkaz:
https://doaj.org/article/d2fb6aac590144e1a7065ef3104958b4
Autor:
Arvind Ramanathan, Andrej J Savol, Christopher J Langmead, Pratul K Agarwal, Chakra S Chennubhotla
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15827 (2011)
Internal motions enable proteins to explore a range of conformations, even in the vicinity of native state. The role of conformational fluctuations in the designated function of a protein is widely debated. Emerging evidence suggests that sub-groups
Externí odkaz:
https://doaj.org/article/3d9d521691d44c2da215457e4881698a
Autor:
Arman W. Mohammad, Konrad Hochedlinger, Jiho Choi, Bruno Di Stefano, Steven P. Gygi, Sang Yong Kim, Ruslan I. Sadreyev, Kaixuan Lin, Ryan M. Walsh, Haruhiko Koseki, Andrew Xiao, Kendell Clement, Andrej J. Savol, Junko Odajima, Justin Brumbaugh, Toshihiro Shioda, Jean Charron, Hongcang Gu, Alexander Meissner, Christopher M. Rose, Aaron J. Huebner, Andreas Gnirke, Jafar Sharif
Publikováno v:
Nature
Concomitant activation of the Wnt pathway and suppression of Mapk signalling by two small molecule inhibitors (2i) in the presence of leukaemia inhibitory factor (LIF) (hereafter termed 2i/L) induces a naive state in mouse embryonic stem (ES) cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd08bd1f99bb99308eed8c2f6744cc3
https://doi.org/10.1038/nature23274
https://doi.org/10.1038/nature23274
Autor:
Clifford J. Tabin, Sharmistha Kundu, Sharon K. Marr, Ruslan I. Sadreyev, Peggy I. Wang, Andrej J. Savol, Matthew G. Schwartz, Daniel J. Grau, Patrick Schorderet, Robert E. Kingston, Mei Sheng Lau
Publikováno v:
Science. 355:1081-1084
Polycomb group gene silencing Histone proteins wrap around DNA to form nucleosomes that package metazoan DNA into the nucleus. Chromatin compaction is also believed to be critical for the repression of homeotic genes by the Polycomb repressive comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8a8bba1e08f492c70f543203520073
https://doi.org/10.1126/science.aah5403
https://doi.org/10.1126/science.aah5403
Autor:
Filip K. Swirski, Hiroko Wakimoto, Gabriel Courties, Lucile Miquerol, Peter Libby, Alan Hanley, Hendrik B. Sager, Ruslan I. Sadreyev, Christine E. Seidman, David J. Milan, Nicolas Da Silva, Kevin R. King, Richard N. Mitchell, Yuan Sun, Claudio Vinegoni, Yoshiko Iwamoto, Aaron D. Aguirre, Andrej J. Savol, Kory J. Lavine, Ling Xiao, Gunnar Seemann, Jonathan G. Seidman, Peter Kohl, Eike M. Wülfers, William J. Hucker, Maarten Hulsmans, Matthias Nahrendorf, Dennis Brown, Sebastian Clauss, Diane E. Capen, Ralph Weissleder, Gregory A. Fishbein, Kamila Naxerova, Patrick T. Ellinor
Publikováno v:
Cell, vol 169, iss 3
Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely interspers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfdaa16e999a689bd73ac5b4eb0b953
http://hdl.handle.net/10379/12013
http://hdl.handle.net/10379/12013
Autor:
Aaron J. Huebner, Christopher M. Rose, Raul Mostoslavsky, Justin Brumbaugh, Jamie Orme Webster, Ruslan I. Sadreyev, Patrick Boyle, Ryan M. Walsh, Jean-Pierre Etchegaray, Andrej J. Savol, Peter J. Park, Ulrich Elling, Kendell Clement, Konrad Hochedlinger, Hongcang Gu, Alexander Meissner, Soohyun Lee, Jiho Choi, Steven P. Gygi
Publikováno v:
Cell Stem Cell
Blastocyst-derived embryonic stem cells (ESCs) and gonad-derived embryonic germ cells (EGCs) represent two classic types of pluripotent cell lines, yet their molecular equivalence remains incompletely understood. Here, we compare genome-wide methylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edc1b2fad21f813722e2f68d61c3e1f
https://europepmc.org/articles/PMC5524993/
https://europepmc.org/articles/PMC5524993/
Autor:
Christina M. Palmieri, Ruslan I. Sadreyev, Shannan J. Ho Sui, Isabel A. Calvo, Andrej J. Savol, Meeta Mistry, Martin J. Aryee, Jasbeer Singh Khanduja, Mo Motamedi, Richard I. Joh
Quiescence (G0) is a ubiquitous stress response through which cells enter reversible dormancy, acquiring distinct properties including reduced metabolism, resistance to stress and long life. G0 entry involves dramatic changes to chromatin and transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963a4fe49330267557dc9e788bd0b70a
https://europepmc.org/articles/PMC5180613/
https://europepmc.org/articles/PMC5180613/
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 80:2536-2551
Biomolecular simulations at milli-second and longer timescales can provide vital insights into functional mechanisms. Since post-simulation analyses of such large trajectory data-sets can be a limiting factor in obtaining biological insights, there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::037d4f7b36cdda3c6f75b723a5615089
https://doi.org/10.1002/prot.24135
https://doi.org/10.1002/prot.24135
Autor:
Andrej J. Savol, Chakra Chennubhotla
Systems of many interacting components, as found in physics, biology, infrastructure, and the social sciences, are often modeled by simple networks of nodes and edges. The real-world systems frequently confront outside intervention or internal damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa28392588875268005c9e825661261
https://europepmc.org/articles/PMC4769078/
https://europepmc.org/articles/PMC4769078/
Autor:
Christopher J. Langmead, Arvind Ramanathan, Pratul K. Agarwal, Chakra Chennubhotla, Andrej J. Savol
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e15827 (2011)
PLoS ONE, Vol 6, Iss 1, p e15827 (2011)
Background Internal motions enable proteins to explore a range of conformations, even in the vicinity of native state. The role of conformational fluctuations in the designated function of a protein is widely debated. Emerging evidence suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c3d2772eccdfd06d59cbcd4633f860