C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

Autor: Ana Rita Lourenço, M. Guy Roukens, Danielle Seinstra, Cynthia L. Frederiks, Cornelieke E. Pals, Stephin J. Vervoort, Andreia S. Margarido, Jacco van Rheenen, Paul J. Coffer

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.

Externí odkaz: https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b

Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases

Autor: Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen

Publikováno v: Margarido, A S, Uceda-Castro, R, Hahn, K, de Bruijn, R, Kester, L, Hofland, I, Lohuis, J, Seinstra, D, Broeks, A, Jonkers, J, Broekman, M L D, Wesseling, P, Vennin, C, Vizoso, M & van Rheenen, J 2022, ' Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases ', Cancers, vol. 14, no. 13, 3115 . https://doi.org/10.3390/cancers14133115
Cancers; Volume 14; Issue 13; Pages: 3115
Cancers, 14(13):3115. Multidisciplinary Digital Publishing Institute (MDPI)

(1) Background: an increasing number of breast cancer patients develop lethal brain metastases (BM). The complete removal of these tumors by surgery becomes complicated when cells infiltrate into the brain parenchyma. However, little is known about t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbb87842d58808de77f2e11796cb6e3
https://research.vumc.nl/en/publications/0787a063-65b2-432b-b832-a08de55048f5

PROX1 is a specific and dynamic marker of sacral neural crest cells in the chicken intestine

Autor: Pascal de Santa Barbara, Andreia S Margarido, Amandine Falco, Sandrine Faure, Norbert Chauvet, Ludovic Le Guen

Publikováno v: Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, In press, ⟨10.1002/cne.24801⟩
Journal of Comparative Neurology, Wiley, In press, 528, pp.879. ⟨10.1002/cne.24801⟩

International audience; The Enteric Nervous System (ENS) is a complex network constituted of neurons and glial cells that ensures the intrinsic innervation of the gastrointestinal tract. ENS cells originate from vagal and sacral neural crest cells th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7ac94ef2a4353242ee0d2d68c67256
https://hal.archives-ouvertes.fr/hal-02332399/file/MargaridoetalJCN2019full.pdf

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

Autor: Herke Jan Noordmans, Tom J. Snijders, Maria Alieva, Burcin Colak, Jacco van Rheenen, Erik R. Abels, Carla Boquetale, Tamara Wieles, Marike L. D. Broekman, Andreia S Margarido

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, 7(1). Nature Publishing Group
Scientific Reports
Scientific Reports, 7. Nature Publishing Group

Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0ad89dbf5243a944fc6adfb3a2e697
https://doi.org/10.1038/s41598-017-07660-4