Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Andreia Neves-Carvalho"'
Autor:
Arpita Chatterjee, Saikat Saha, Anirban Chakraborty, Anabela Silva-Fernandes, Santi M Mandal, Andreia Neves-Carvalho, Yongping Liu, Raj K Pandita, Muralidhar L Hegde, Pavana M Hegde, Istvan Boldogh, Tetsuo Ashizawa, Arnulf H Koeppen, Tej K Pandita, Patricia Maciel, Partha S Sarkar, Tapas K Hazra
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1011124 (2024)
[This corrects the article DOI: 10.1371/journal.pgen.1004749.].
Externí odkaz:
https://doaj.org/article/35d8c4e7cc8048d1a6e35ea051295bfe
Autor:
Kristin Mayoral-Palarz, Andreia Neves-Carvalho, Sara Duarte-Silva, Daniela Monteiro-Fernandes, Patrícia Maciel, Kamran Khodakhah
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Spinocerebellar ataxia type 3 (SCA3) is an adult-onset, progressive ataxia. SCA3 presents with ataxia before any gross neuropathology. A feature of many cerebellar ataxias is aberrant cerebellar output that contributes to motor dysfunction. We examin
Externí odkaz:
https://doaj.org/article/1a36b8cb4e1641fdae0c96350de5b7d4
Autor:
Daniela Cunha-Garcia, Daniela Monteiro-Fernandes, Joana Sofia Correia, Andreia Neves-Carvalho, Ana Catarina Vilaça-Ferreira, Sónia Guerra-Gomes, João Filipe Viana, João Filipe Oliveira, Andreia Teixeira-Castro, Patrícia Maciel, Sara Duarte-Silva
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10606 (2023)
Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disease caused by an abnormal polyglutamine expansion within the ataxin-3 protein (ATXN3). This leads to neurodegeneration of specific brain and spinal cord regions, resulting in a prog
Externí odkaz:
https://doaj.org/article/4db11ae77c6e45a080c27d4ec9e9241c
Autor:
Rui Lima, Eduardo D. Gomes, Jorge R. Cibrão, Luís A. Rocha, Rita C. Assunção-Silva, Cláudia S. Rodrigues, Andreia Neves-Carvalho, Susana Monteiro, António J. Salgado, Nuno A. Silva
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Spinal cord injury (SCI) leads to dramatic impairments of motor, sensory, and autonomic functions of affected individuals. Following the primary injury, there is an increased release of glutamate that leads to excitotoxicity and further neur
Externí odkaz:
https://doaj.org/article/6381c90cd2744b65acae2876e1faad97
Autor:
Ana Bela Campos, Sara Duarte-Silva, Bruno Fernandes, Sofia Pereira das Neves, Fernanda Marques, Andreia Teixeira-Castro, Andreia Neves-Carvalho, Daniela Monteiro-Fernandes, Camila Cabral Portugal, Renato Socodato, Teresa Summavielle, António Francisco Ambrósio, João Bettencourt Relvas, Patrícia Maciel
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 237 (2022)
Microglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs. Yet, the microglial profile in Machado–Joseph disease (MJD) remain
Externí odkaz:
https://doaj.org/article/bfa831bc12074691918231a72b6199b4
Autor:
Joana Sofia Correia, Andreia Neves-Carvalho, Bárbara Mendes-Pinheiro, Joel Pires, Fábio Gabriel Teixeira, Rui Lima, Susana Monteiro, Nuno André Silva, Carina Soares-Cunha, Sofia Cravino Serra, Sara Duarte-Silva, Andreia Teixeira-Castro, António José Salgado, Patrícia Maciel
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1754 (2021)
The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies for neurodegenerative diseases, including spinocerebellar ataxias. Spinocerebellar ataxia type 3 (SCA3)—or M
Externí odkaz:
https://doaj.org/article/692ddb03d70d40f8b32e77886b2612ce
Autor:
Sofia Esteves, Sara Duarte-Silva, Luana Naia, Andreia Neves-Carvalho, Andreia Teixeira-Castro, Ana Cristina Rego, Anabela Silva-Fernandes, Patrícia Maciel
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141610 (2015)
Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic
Externí odkaz:
https://doaj.org/article/8961ab4612054489a68cfa73e0f680b5
Autor:
Arpita Chatterjee, Saikat Saha, Anirban Chakraborty, Anabela Silva-Fernandes, Santi M Mandal, Andreia Neves-Carvalho, Yongping Liu, Raj K Pandita, Muralidhar L Hegde, Pavana M Hegde, Istvan Boldogh, Tetsuo Ashizawa, Arnulf H Koeppen, Tej K Pandita, Patricia Maciel, Partha S Sarkar, Tapas K Hazra
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004749 (2015)
DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) intermediates. Several neurological diseases have already been identified a
Externí odkaz:
https://doaj.org/article/816f1319fae448229cf3154cfe1d4f34
Publikováno v:
Stem Cells International, Vol 2014 (2014)
The goal of this study was to determine and compare the effects of the secretome of mesenchymal stem cells (MSCs) isolated from human bone-marrow (BMSCs) and the Wharton jelly surrounding the vein and arteries of the umbilical cord (human umbilical c
Externí odkaz:
https://doaj.org/article/c89eae7be9b148e2ab0628dafddc3e42
Autor:
Ana João Rodrigues, Andreia Neves-Carvalho, Andreia Teixeira-Castro, Anne Rokka, Garry Corthals, Elsa Logarinho, Patrícia Maciel
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18512 (2011)
Ataxin-3, the protein involved in Machado-Joseph disease, is able to bind ubiquitylated substrates and act as a deubiquitylating enzyme in vitro, and it has been involved in the modulation of protein degradation by the ubiquitin-proteasome pathway. C
Externí odkaz:
https://doaj.org/article/9a0fd5ae62ea4b98964b50f57fe31678