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pro vyhledávání: '"Andrei Yudin"'
Biaryl and heterobiaryl-containing cyclic peptides represent promising scaffolds in the development of bioactive molecules. The incorporation of heterobiaryl motifs continues to pose synthetic challenges, which is partially due to the difficulties in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6dba7a51efc35c43b195aac718e9a68
https://doi.org/10.26434/chemrxiv-2023-frwx6
https://doi.org/10.26434/chemrxiv-2023-frwx6
While peptide macrocycles with rigid conformations have proven to be useful in the design of chemical probes against protein targets, conformational flexibility and rapid conformational interconversion can be equally vital for biological activity. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d4a93edb78926c24da8bab8a068e7f
https://doi.org/10.26434/chemrxiv-2022-gfsfj
https://doi.org/10.26434/chemrxiv-2022-gfsfj
Publikováno v:
RSC chemical biology. 3(8)
Gong Chen, Monika Raj and Andrei Yudin introduce the RSC Chemical Biology themed collection on the ‘Synthesis and chemical biology of macrocycles’.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8255f6b287da933d5141e4a11017ba
https://pubmed.ncbi.nlm.nih.gov/35975002
https://pubmed.ncbi.nlm.nih.gov/35975002
A new boron-containing heterocyclic scaffold – borindolizine – is reported as a new heterocyclic scaffold with broadly tunable fluorescence and a high Stokes shift. Two classes of emitters were synthesized through rational scaffold changes result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e12cce904198067d8bbe827ab597d6c
https://doi.org/10.26434/chemrxiv-2022-qwjgp
https://doi.org/10.26434/chemrxiv-2022-qwjgp
Herein, we apply the principle of iminology to the well-established epoxide ring-closure reaction. The synthesis of tetrasubstituted, nitrile-tethered epoxides can be achieved via activation of iminologous diols followed by fragmentation. Mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf69d1a72b4fab25834990e398829951
https://doi.org/10.26434/chemrxiv-2022-rjc20
https://doi.org/10.26434/chemrxiv-2022-rjc20
Autor:
George Saunders, Andrei Yudin
Passive membrane permeability is a fundamental challenge in the development of bioactive macrocycles. To achieve this objective, chemists have resorted to various strategies, the most common of which is deployment of N-methylated amino acids and/or D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1784d84a078b97f9d30a6b8100ce3d3d
https://doi.org/10.26434/chemrxiv-2022-nq98h
https://doi.org/10.26434/chemrxiv-2022-nq98h
Autor:
Andrei Yudin
This essay tackles the topic of what is discoverable by humans and why it is essential to have diversity of cultural, ethnic, and gender backgrounds in science.
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https://explore.openaire.eu/search/publication?articleId=doi_________::d525c3c25d4a04b8f096708a9d06f9ab
https://doi.org/10.26434/chemrxiv.12436637
https://doi.org/10.26434/chemrxiv.12436637
Autor:
Andrei Yudin, Richard Lee, Aaron Schimmer, Gennady Poda, Anastasia Bogdanchikova, Wenjie Shao, Elizabeth Griffith, Diego Diaz, Yulia Jitkova, Julie Jungberg Grouleff, Joanne Tan
Boronic acids have attracted the attention of synthetic and medicinal chemists due to boron’s ability to modulate enzyme function. Recently, we demonstrated that boron-containing amphoteric building blocks facilitate the discovery of bioactive amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::094332edf2da4786e6e977c4e54a4a7b
https://doi.org/10.26434/chemrxiv.7408565
https://doi.org/10.26434/chemrxiv.7408565
Autor:
Andrei Yudin
Publikováno v:
ECS Meeting Abstracts. :992-992
not Available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecfcbce9256c61c5c4db1d33bbdbfc6
https://doi.org/10.1149/ma2006-01/29/992
https://doi.org/10.1149/ma2006-01/29/992
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