Exploring the Influence of Zinc Ions on the Conformational Stability and Activity of Protein Disulfide Isomerase

Autor: Ana Iochabel Soares Moretti, Viktoria E. Baksheeva, Andrei Yu. Roman, Tiphany Coralie De Bessa, François Devred, Hervé Kovacic, Philipp O. Tsvetkov

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 4, p 2095 (2024)

The interplay between metal ion binding and the activity of thiol proteins, particularly within the protein disulfide isomerase family, remains an area of active investigation due to the critical role that these proteins play in many vital processes.

Externí odkaz: https://doaj.org/article/60674322f25d441790c3e03e0cc407a6

Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

Autor: Cyrille Garnier, François Devred, Deborah Byrne, Rémy Puppo, Andrei Yu. Roman, Soazig Malesinski, Andrey V. Golovin, Régine Lebrun, Natalia N. Ninkina, Philipp O. Tsvetkov

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Aggregation of TDP-43 (transactive response DNA binding protein 43 kDa) is a hallmark of certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, intracellular TDP-43-positive inclusions ar

Externí odkaz: https://doaj.org/article/2c0c8563f1e940049ce56f22e73b5816

Zinc Binds to RRM2 Peptide of TDP-43

Autor: Andrey V. Golovin, Francois Devred, Dahbia Yatoui, Andrei Yu. Roman, Arthur O. Zalevsky, Remy Puppo, Regine Lebrun, Francoise Guerlesquin, Philipp O. Tsvetkov

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 23, p 9080 (2020)

Transactive response DNA and RNA binding protein 43 kDa (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP), which is involved in several steps of protein production including transcription and splicing. Its aggregates are

Externí odkaz: https://doaj.org/article/65cdb9c6b39a40f0bd9a44b71860ce14

Mechanism of Zn

Autor: Viktoriia E, Baksheeva, Andrei Yu, Roman, Claude, Villard, François, Devred, Deborah, Byrne, Dahbia, Yatoui, Arthur O, Zalevsky, Alisa A, Vologzhannikova, Andrey S, Sokolov, Sergei E, Permyakov, Andrey V, Golovin, Gary S, Shaw, Philipp O, Tsvetkov, Evgeni Yu, Zernii

Publikováno v: Biomolecules

S100A1 is a member of the S100 family of small ubiquitous Ca2+-binding proteins, which participates in the regulation of cell differentiation, motility, and survival. It exists as homo- or heterodimers. S100A1 has also been shown to bind Zn2+, but th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71317294142431a4efff31ccc08ee2d2
https://pubmed.ncbi.nlm.nih.gov/34944467

Zinc Binds to RRM2 Peptide of TDP-43

Autor: Françoise Guerlesquin, Rémy Puppo, Andrei Yu. Roman, Arthur O. Zalevsky, Régine Lebrun, Dahbia Yatoui, François Devred, Andrey V. Golovin, Philipp O. Tsvetkov

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 9080, p 9080 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2020, 21 (23), pp.9080. ⟨10.3390/ijms21239080⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (23), pp.9080. ⟨10.3390/ijms21239080⟩
Volume 21
Issue 23

Transactive response DNA and RNA binding protein 43 kDa (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP), which is involved in several steps of protein production including transcription and splicing. Its aggregates are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ed30a3e2a0888efaab469c092640a2
https://www.mdpi.com/1422-0067/21/23/9080