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Autor:
Hyun Joo, Vyacheslav V. Samoshin, G. V. Grishina, I. S. Veselov, Andrey V. Samoshin, Andrei Ya Korneichuk
Publikováno v:
Tetrahedron Letters. 54:1020-1024
Derivatives of trans-3-hydroxy-4-aminopiperidine are suggested as potential pH-sensitive conformational switches able to perform two consecutive flips (or flip–flop) when basicity/acidity of solution changes. Such a double switch of conformation wa