Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Andrei V, Krivtsov"'
Autor:
Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain
Externí odkaz:
https://doaj.org/article/a470abd9ea4643cfb47136bbe875cfb7
Autor:
Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Publikováno v:
Cancer Discovery. 13:146-169
Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5aebdeae24ecc0935e8aeab3707bed
https://doi.org/10.1158/2159-8290.cd-22-0416
https://doi.org/10.1158/2159-8290.cd-22-0416
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
ChIP-Seq results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17caa0aa8fb1356b5a7ce1ae746170e7
https://doi.org/10.1158/2159-8290.22542055
https://doi.org/10.1158/2159-8290.22542055
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
Sequences of sgRNAs and primers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcda721a657db3047fd126e2892aadd
https://doi.org/10.1158/2159-8290.22542061
https://doi.org/10.1158/2159-8290.22542061
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2f9a27688c8427afa406f20015bed3
https://doi.org/10.1158/2159-8290.c.6549793
https://doi.org/10.1158/2159-8290.c.6549793
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
RNA-Seq results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42753da56fe296de83bbedd0357e9a1f
https://doi.org/10.1158/2159-8290.22542052
https://doi.org/10.1158/2159-8290.22542052
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
CRISPR screen results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0028c2acb2959b0e069ce9a57ca288
https://doi.org/10.1158/2159-8290.22542058.v1
https://doi.org/10.1158/2159-8290.22542058.v1
Autor:
Alex Kentsis, Scott A. Armstrong, Jarrod A Marto, Ross Levine, Gayle Pouliot, Guy Sauvageau, Anthony Letai, Martin S. Tallman, Elisabeth M. Paietta, Ari Melnick, Andrei V. Krivtsov, Josée Hébert, Vincent-Philippe Lavallée, Crystal Stutzke, Barbara Spitzer, Conor O'Donnell, Patrick Bhola, Venkatraman Seshan, Mithat Gonen, Elisa de Stanchina, Craig McCarthy, Willie Mark, Peter Romanienko, Scott B. Ficarro, Shehana Gunasekera, Casie Reed, Paolo Cifani, Sumiko Takao, Christina Y. Yim, Richard P. Koche, Eric Still, Fiona C. Brown
Extended methods, supplementary figures and supplementary tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665b2c7724bfc1ebf56cbdf4d423cc22
https://doi.org/10.1158/2159-8290.22532377.v1
https://doi.org/10.1158/2159-8290.22532377.v1
Data S2 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia
Autor:
Alex Kentsis, Scott A. Armstrong, Jarrod A Marto, Ross Levine, Gayle Pouliot, Guy Sauvageau, Anthony Letai, Martin S. Tallman, Elisabeth M. Paietta, Ari Melnick, Andrei V. Krivtsov, Josée Hébert, Vincent-Philippe Lavallée, Crystal Stutzke, Barbara Spitzer, Conor O'Donnell, Patrick Bhola, Venkatraman Seshan, Mithat Gonen, Elisa de Stanchina, Craig McCarthy, Willie Mark, Peter Romanienko, Scott B. Ficarro, Shehana Gunasekera, Casie Reed, Paolo Cifani, Sumiko Takao, Christina Y. Yim, Richard P. Koche, Eric Still, Fiona C. Brown
Processed data for S222A+ and S222A- cells by RNA and ATAC sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a290ee3befe02ecdc4208f73225e39
https://doi.org/10.1158/2159-8290.22532386
https://doi.org/10.1158/2159-8290.22532386
Publikováno v:
Exp Biol Med (Maywood)
Macrophages, the key cells of innate immunity, possess wide phenotypical and functional heterogeneity. In vitro studies showed that microenvironment signals could induce the so-called polarization of macrophages into two phenotypes: classically activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dbd86f3f151efd6516e420c42f69e6
https://doi.org/10.1177/15353702221080130
https://doi.org/10.1177/15353702221080130