Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Andrei Leonov"'
Autor:
Kumar Tekwani Movellan, Melanie Wegstroth, Kerstin Overkamp, Andrei Leonov, Stefan Becker, Loren B. Andreas
Publikováno v:
Journal of Structural Biology: X, Vol 8, Iss , Pp 100090- (2023)
The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelles, and in
Externí odkaz:
https://doaj.org/article/6126c5d4268f427484adf5d7d99bc435
Autor:
Leif Antonschmidt, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky, Vrinda Sant, Sergey Ryazanov, Armin Giese, Gunnar F. Schröder, Stefan Becker, Bert L. de Groot, Christian Griesinger, Loren B. Andreas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Understanding how small molecules bind to pathological aggregates is of importance for therapeutic and diagnostic development in diseases such as Parkinson’s Disease. Here, the authors reveal a binding site of anle138b to lipid-induced α-synuclein
Externí odkaz:
https://doaj.org/article/ed3eab20b6124a5585faf679ec466929
Autor:
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W. Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104021- (2022)
Summary: Background: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates (oligomers) of α-
Externí odkaz:
https://doaj.org/article/2aeca4c5452945a2b232932da803dc99
Autor:
Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning, Nadia Stefanova
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-14 (2020)
Abstract Background Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of α-synucleinopathies including Parkinson’s disease and multiple system atrophy, and its detection parallels activation of microglia and a loss of neur
Externí odkaz:
https://doaj.org/article/ef88796be9ef4ed0aba14c1021ca1753
Autor:
Andrey Filippov, Andrey Vorontsov, Nickolay Shamarin, Evgeny Moskvichev, Olga Novitskaya, Evgeny Knyazhev, Yuliya Denisova, Andrei Leonov, Vladimir Denisov, Sergei Tarasov
Publikováno v:
Metals, Vol 12, Iss 12, p 2046 (2022)
In this work, we studied single-layer ZrN and CrN coatings, as well as multi-layer ZrN/CrN coatings deposited by the vacuum-arc method on WC-8 wt.% Co substrates. The sliding friction parameters were preset to simulate different operating conditions
Externí odkaz:
https://doaj.org/article/8f04ce4037954be6a51492d88da85b6b
Autor:
Andrey Vorontsov, Andrey Filippov, Nickolay Shamarin, Evgeny Moskvichev, Olga Novitskaya, Evgenii Knyazhev, Yuliya Denisova, Andrei Leonov, Vladimir Denisov, Sergei Tarasov
Publikováno v:
Metals, Vol 12, Iss 10, p 1746 (2022)
Multilayer nitride coatings provide some of the best performance when in their use for the production of metalworking tools. In this work, vacuum-arc plasma-assisted deposited multilayer ZrN/CrN coatings with different numbers of constituent layers w
Externí odkaz:
https://doaj.org/article/6a6066c08bbf4b73b8e1c64b54f68cae
Autor:
Matthias Brendel, Maximilian Deussing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters, Barbara von Ungern-Sternberg, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Igor Yakushev, Paul Cumming, Guido Boening, Sibylle Ziegler, Jochen Herms, Armin Giese, Axel Rominger
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background Augmenting the brain clearance of toxic oligomers with small molecule modulators constitutes a promising therapeutic concept against tau deposition. However, there has been no test of this concept in animal models of Alzheimer’s
Externí odkaz:
https://doaj.org/article/3b973999c8e94cd6996a2a71167a7056
Autor:
Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2017)
Abstract Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcrip
Externí odkaz:
https://doaj.org/article/c508142ad7ed44dda436f67105c1fa85
Autor:
Garima Jaipuria, Andrei Leonov, Karin Giller, Suresh Kumar Vasa, Łukasz Jaremko, Mariusz Jaremko, Rasmus Linser, Stefan Becker, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
The outer mitochondrial membrane translocator protein (TSPO) mediates several mitochondrial functions and binds cholesterol with a high affinity. Here the authors use solid-state NMR to show that cholesterol binding to TSPO results in allosteric chan
Externí odkaz:
https://doaj.org/article/a46da088e92c420c87ebaa77aef97943
Autor:
Rıza Dervişoğlu, Leif Antonschmidt, Evgeny Nimerovsky, Vrinda Sant, Myeongkyu Kim, Sergey Ryazanov, Andrei Leonov, Juan Carlos Fuentes-Monteverde, Melanie Wegstroth, Karin Giller, Guinevere Mathies, Armin Giese, Stefan Becker, Christian Griesinger, Loren B. Andreas
Publikováno v:
Methods
Small molecules that bind to oligomeric protein species such as membrane proteins and fibrils are of clinical interest for development of therapeutics and diagnostics. Definition of the binding site at atomic resolution via NMR is often challenging d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598dc56d67aa151e6216ac6fbf50f8b6
https://doi.org/10.1016/j.ymeth.2023.04.002
https://doi.org/10.1016/j.ymeth.2023.04.002