Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Andrei Leitão"'
Autor:
Fernanda A. H. Batista, Sérgio L. Ramos, Giusy Tassone, Andrei Leitão, Carlos A. Montanari, Maurizio Botta, Mattia Mori, Júlio C. Borges
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 639-649 (2020)
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These
Externí odkaz:
https://doaj.org/article/1eb2af2ab0394a7fb2e4c0e33e4550a4
Autor:
Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda Dos Reis Rocho, Jean F R Ribeiro, Daiane Y Tezuka, Carla D Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos A Montanari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007755 (2020)
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map it
Externí odkaz:
https://doaj.org/article/3510716dcbcc410e83482bb1244acca6
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0222055 (2019)
Cruzain, a cysteine protease of Trypanosoma cruzi, is a validated target for the treatment of Chagas disease. Due to its high similarity in three-dimensional structure with human cathepsins and their sequence identity above 70% in the active site reg
Externí odkaz:
https://doaj.org/article/0a814f2c089a4c8bac5ded449012fd76
Autor:
Antonio C B Burtoloso, Sérgio de Albuquerque, Mark Furber, Juliana C Gomes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, Carlos A Montanari, José Carlos Quilles, Jean F R Ribeiro, Josmar R Rocha
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005343 (2017)
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for
Externí odkaz:
https://doaj.org/article/c040bb0a668b427ebd712530ad099df5
Autor:
Leandro A A Avelar, Cristian D Camilo, Sérgio de Albuquerque, William B Fernandes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, James H McKerrow, Carlos A Montanari, Erika V Meñaca Orozco, Jean F R Ribeiro, Josmar R Rocha, Fabiana Rosini, Marta E Saidel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003916 (2015)
A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and
Externí odkaz:
https://doaj.org/article/c07c0749619b40c0b5dab804ecd2bd13
Autor:
Vera Lúcia de Almeida, Andrei Leitão, Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Míriam Teresa Paz Lopes
Publikováno v:
Química Nova, Vol 28, Iss 1, Pp 118-129 (2005)
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthe
Externí odkaz:
https://doaj.org/article/9641afe022344144b65ee19de0a11289
Publikováno v:
Química Nova, Vol 23, Iss 2, Pp 178-184 (2000)
Combinatorial chemistry has emerged as a tool to circumvent a major problem of pharmaceutical industries to discover new lead compounds. A rapid and massive evaluation of a myriad of newly synthesised compounds can be carried out. Combinatorial synth
Externí odkaz:
https://doaj.org/article/3b9f85256868428caee7439f033acad3
Autor:
Vinícius Bonatto, Rafael F. Lameiro, Fernanda R. Rocho, Jerônimo Lameira, Andrei Leitão, Carlos A. Montanari
Publikováno v:
RSC Medicinal Chemistry. 14:201-217
This review highlights the roles of nitriles in covalent inhibitors, their reactivity, examples of pharmaceuticals containing the cyano group and recent developments of nitrile-based inhibitors.
Autor:
V. Craig Jordan, James R. Paige, Dong Cheng, Anne L. Donato, Alexis Madrack, Jennifer R. Pyle, Heather A. Shupp, Helen R. Kim, Shaun D. Gill, Catherine G.N. Sharma, Anne Marie Bertucci, Teresa Louis, Bin Chen, Tudor I. Oprea, Andrei Leitão, Eric A. Ariazi
Supplementary Tables from Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2d5c3546f9cdc47b899800c1052b60
https://doi.org/10.1158/1535-7163.22485612
https://doi.org/10.1158/1535-7163.22485612
Autor:
V. Craig Jordan, James R. Paige, Dong Cheng, Anne L. Donato, Alexis Madrack, Jennifer R. Pyle, Heather A. Shupp, Helen R. Kim, Shaun D. Gill, Catherine G.N. Sharma, Anne Marie Bertucci, Teresa Louis, Bin Chen, Tudor I. Oprea, Andrei Leitão, Eric A. Ariazi
Adobe PDF - MCT-07-0312--Suppl_Fig_S2.pdf from Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68350445411b7bc9f8f588a563360a30
https://doi.org/10.1158/1535-7163.22485621.v1
https://doi.org/10.1158/1535-7163.22485621.v1