Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Andrei L. Osterman"'
Autor:
Aleksandr A. Arzamasov, Aruto Nakajima, Mikiyasu Sakanaka, Miriam N. Ojima, Takane Katayama, Dmitry A. Rodionov, Andrei L. Osterman
Publikováno v:
mSystems, Vol 7, Iss 5 (2022)
ABSTRACT Bifidobacterium longum subsp. infantis is a prevalent beneficial bacterium that colonizes the human neonatal gut and is uniquely adapted to efficiently use human milk oligosaccharides (HMOs) as a carbon and energy source. Multiple studies ha
Externí odkaz:
https://doaj.org/article/15956173b0fc48ddbb03e158ca186497
Autor:
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent
Externí odkaz:
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
Autor:
Jaime E. Zlamal, Semen A. Leyn, Mallika Iyer, Marinela L. Elane, Nicholas A. Wong, James W. Wamsley, Maarten Vercruysse, Fernando Garcia-Alcalde, Andrei L. Osterman
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
The challenge of spreading antibiotic resistance calls for systematic efforts to develop more “irresistible” drugs based on a deeper understanding of dynamics and mechanisms of antibiotic resistance acquisition. To address this challenge, we have
Externí odkaz:
https://doaj.org/article/24c2bf31f14d4d6f8689b162ab43cd66
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The profiling of 16S rRNA revolutionized the exploration of microbiomes, allowing to describe community composition by enumerating relevant taxa and their abundances. However, taxonomic profiles alone lack interpretability in terms of bacterial metab
Externí odkaz:
https://doaj.org/article/a21da3cb636742ea8f0179358f0eae1b
Autor:
Roshonda B. Jones, Paige K. Berger, Jasmine F. Plows, Tanya L. Alderete, Joshua Millstein, Jennifer Fogel, Stanislav N. Iablokov, Dmitry A. Rodionov, Andrei L. Osterman, Lars Bode, Michael I. Goran
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Infant formula feeding, compared with human milk, has been associated with development of a distinct infant gut microbiome, but no previous study has examined effects of formula with added sugars. This work examined differences in gut microbiota amon
Externí odkaz:
https://doaj.org/article/c1ca11950a3849dfaf2d01b382b6217c
Autor:
Vandana Sharma, Dmitry A. Rodionov, Semen A. Leyn, David Tran, Stanislav N. Iablokov, Hua Ding, Daniel A. Peterson, Andrei L. Osterman, Scott N. Peterson
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Cross-feeding on intermediary and end-point metabolites plays an important role in the dynamic interactions of host-associated microbial communities. While gut microbiota possess inherent resilience to perturbation, variations in the intake of certai
Externí odkaz:
https://doaj.org/article/0b037c2bd15044699fffea2295043408
Autor:
Dmitry A. Rodionov, Aleksandr A. Arzamasov, Matvei S. Khoroshkin, Stanislav N. Iablokov, Semen A. Leyn, Scott N. Peterson, Pavel S. Novichkov, Andrei L. Osterman
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The human gut microbiome harbors a diverse array of metabolic pathways contributing to its development and homeostasis via a complex web of diet-dependent metabolic interactions within the microbial community and host. Genomics-based reconstruction a
Externí odkaz:
https://doaj.org/article/f1e94e29d1064d9882604bbadaca3f70
Publikováno v:
Nutrients, Vol 12, Iss 11, p 3380 (2020)
B group vitamins represent essential micronutrients for myriad metabolic and regulatory processes required for human health, serving as cofactors used by hundreds of enzymes that carry out essential functions such as energy metabolism, DNA and protei
Externí odkaz:
https://doaj.org/article/1e00ea932764473f8eccf20609d1725b
Autor:
Irina A. Rodionova, Brian M. Schuster, Kristine M. Guinn, Leonardo Sorci, David A. Scott, Xiaoqing Li, Indu Kheterpal, Carolyn Shoen, Michael Cynamon, Christopher Locher, Eric J. Rubin, Andrei L. Osterman
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT Mycobacterium tuberculosis remains a major cause of death due to the lack of treatment accessibility, HIV coinfection, and drug resistance. Development of new drugs targeting previously unexplored pathways is essential to shorten treatment t
Externí odkaz:
https://doaj.org/article/cd928a37779048cf85d827e12f5c4f8d
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 57:562-584