Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Andrei L, Turinsky"'
Autor:
Henry Quach, Spencer Farrell, Ming Jia Michael Wu, Kayshani Kanagarajah, Joseph Wai-Hin Leung, Xiaoqiao Xu, Prajkta Kallurkar, Andrei L. Turinsky, Christine E. Bear, Felix Ratjen, Brian Kalish, Sidhartha Goyal, Theo J. Moraes, Amy P. Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Studying human fetal lungs can inform how developmental defects and disease states alter the function of the lungs. Here, we sequenced >150,000 single cells from 19 healthy human pseudoglandular fetal lung tissues ranging between gestational
Externí odkaz:
https://doaj.org/article/a4b68a6bade64f2b97f6c7af28a41953
Autor:
Alaina Mahalanabis, Andrei L. Turinsky, Mia Husić, Erik Christensen, Ping Luo, Alaine Naidas, Michael Brudno, Trevor Pugh, Arun K. Ramani, Parisa Shooshtari
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6375-6387 (2022)
Tumors are complex biological entities that comprise cell types of different origins, with different mutational profiles and different patterns of transcriptional dysregulation. The exploration of data related to cancer biology requires careful analy
Externí odkaz:
https://doaj.org/article/ff2bc6b24902403e9edd7b45084e3ccf
Autor:
Sarah J. Goodman, Christie L. Burton, Darci T. Butcher, Michelle T. Siu, Mathieu Lemire, Eric Chater-Diehl, Andrei L. Turinsky, Michael Brudno, Noam Soreni, David Rosenberg, Kate D. Fitzgerald, Gregory L. Hanna, Evdokia Anagnostou, Paul D. Arnold, Jennifer Crosbie, Russell Schachar, Rosanna Weksberg
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-15 (2020)
Abstract Background A growing body of research has demonstrated associations between specific neurodevelopmental disorders and variation in DNA methylation (DNAm), implicating this molecular mark as a possible contributor to the molecular etiology of
Externí odkaz:
https://doaj.org/article/e2c63c023729431c9951220028dadec0
Publikováno v:
Epigenetics, Vol 14, Iss 2, Pp 109-117 (2019)
Buccal epithelial cells are among the most clinically accessible tissues and are increasingly being used to identify epigenetic disease patterns. However, substantial variation in buccal DNA methylation patterns indicates heterogeneity of cell types
Externí odkaz:
https://doaj.org/article/c3501797846f4fa3bada00c67709a901
Autor:
Zain, Awamleh, Sarah, Goodman, Prajkta, Kallurkar, Wendy, Wu, Kevin, Lu, Sanaa, Choufani, Andrei L, Turinsky, Rosanna, Weksberg
Publikováno v:
Current Protocols. 2
There are more than 700 genes that encode proteins that function in epigenetic regulation and chromatin modification. Germline variants in these genes (typically heterozygous) are associated with rare neurodevelopmental disorders (NDDs) characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1349af051877d38d398093f9b6caa2
https://doi.org/10.1002/cpz1.597
https://doi.org/10.1002/cpz1.597
Autor:
Wenlian Qiao, Weijia Wang, Elisa Laurenti, Andrei L Turinsky, Shoshana J Wodak, Gary D Bader, John E Dick, Peter W Zandstra
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 7, Pp 1-18 (2014)
Abstract The hematopoietic system is a distributed tissue that consists of functionally distinct cell types continuously produced through hematopoietic stem cell (HSC) differentiation. Combining genomic and phenotypic data with high‐content experim
Externí odkaz:
https://doaj.org/article/691d206a2b564fdf948695529598fe7f
Autor:
Edyta Marcon, Zuyao Ni, Shuye Pu, Andrei L. Turinsky, Sandra Smiley Trimble, Jonathan B. Olsen, Rosalind Silverman-Gavrila, Lorelei Silverman-Gavrila, Sadhna Phanse, Hongbo Guo, Guoqing Zhong, Xinghua Guo, Peter Young, Swneke Bailey, Denitza Roudeva, Dorothy Zhao, Johannes Hewel, Joyce Li, Susanne Gräslund, Marcin Paduch, Anthony A. Kossiakoff, Mathieu Lupien, Andrew Emili, Shoshana J. Wodak, Jack Greenblatt
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 297-310 (2014)
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, th
Externí odkaz:
https://doaj.org/article/1fec600c0aea446f95652573d57c6bfd
Autor:
Dermot P.B. McGovern, Iram Siddiqui, Claudia Gonzaga-Jauregui, Aleixo M. Muise, Jamie Hu, Michael Brudno, Peter C Church, Scott B. Snapper, Dalin Li, Shiqi Zhang, Andrew D. Paterson, Jie Pan, Daniel Kotlarz, Anne M. Griffiths, Sam Khalouei, Dana M. Bronte-Tinkew, Karoline Fiedler, Chaim M. Roifman, Holm H. Uhlig, Thomas D. Walters, Eileen Crowley, Christoph Klein, Justin Foong, David Tian, Julie E. Horowitz, Abdul Elkadri, Donna A. Wall, Andrei L. Turinsky, Neil Warner, Julia Upton, Arun K. Ramani
Publikováno v:
Gastroenterology
Paediatrics Publications
Paediatrics Publications
Background & Aims: A proportion of infants and young children with inflammatory bowel diseases (IBDs) have subtypes associated with a single gene variant (monogenic IBD). We aimed to determine the prevalence of monogenic disease in a cohort of pediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77b7ab4fbc40abbcac0c6c285171c93
https://doi.org/10.1053/j.gastro.2020.02.023
https://doi.org/10.1053/j.gastro.2020.02.023
Autor:
Hannah G, Driver, Taila, Hartley, E Magda, Price, Andrei L, Turinsky, Orion J, Buske, Matthew, Osmond, Arun K, Ramani, Emily, Kirby, Kristin D, Kernohan, Madeline, Couse, Hillary, Elrick, Kevin, Lu, Pouria, Mashouri, Aarthi, Mohan, Delvin, So, Conor, Klamann, Hannah G B H, Le, Andrea, Herscovich, Christian R, Marshall, Andrew, Statia, Care Rare, Canada Consortium, Bartha M, Knoppers, Michael, Brudno, Kym M, Boycott
Publikováno v:
Human mutation. 43(6)
Despite recent progress in the understanding of the genetic etiologies of rare diseases (RDs), a significant number remain intractable to diagnostic and discovery efforts. Broad data collection and sharing of information among RD researchers is there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2509daedec9a1cd7a4cbef0069405502
https://pubmed.ncbi.nlm.nih.gov/35181971
https://pubmed.ncbi.nlm.nih.gov/35181971
Publikováno v:
International Journal of Nanomedicine, Vol 2009, Iss default, Pp 79-89 (2009)
Jung Soh1, Andrei L Turinsky1, Quang M Trinh1, Jasmine Chang1, Ajay Sabhaney1, et al1Sun Center of Excellence for Visual Genomics, University of Calgary, Calgary, AB, Canada; 2Department of Biological Sciences, University of Alberta, Edmonton, AB, Ca
Externí odkaz:
https://doaj.org/article/725ce34e298c4ac89bbf6eaa2864f42e