Clonal lineage of high grade serous ovarian cancer in a patient with neurofibromatosis type 1

Autor: Eric J. Norris, Wendell D. Jones, Marius D. Surleac, Andrei J. Petrescu, Darla Destephanis, Qing Zhang, Issam Hamadeh, Jeffrey S. Kneisl, Chad A. Livasy, Ram N. Ganapathi, David L. Tait, Mahrukh K. Ganapathi

Publikováno v: Gynecologic Oncology Reports, Vol 23, Iss C, Pp 41-44 (2018)

Neurofibromatosis type 1 (NF1) is caused by mutations in the NF1 gene encoding neurofibromin, which negatively regulates Ras signaling. NF1 patients have an increased risk of developing early onset breast cancer, however, the association between NF1

Externí odkaz: https://doaj.org/article/36019dcd99444d79b87027ded525eddd

NLRscape: an atlas of plant NLR proteins

Autor: Eliza C Martin, Catalin F Ion, Florin Ifrimescu, Laurentiu Spiridon, Jaap Bakker, Aska Goverse, Andrei-J Petrescu

Publikováno v: Nucleic acids research 51 (2023) D1
Nucleic acids research, 51(D1), D1470-D1482

NLRscape is a webserver that curates a collection of over 80 000 plant protein sequences identified in UniProtKB to contain NOD-like receptor signatures, and hosts in addition a number of tools aimed at the exploration of the complex sequence landsca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5b1ff6a914e1f69e65a2953a2aa534
https://doi.org/10.1093/nar/gkac1014

Structure–function analysis of ZAR1 immune receptor reveals key molecular interactions for activity

Autor: Maël Baudin, Andrei J. Petrescu, Jennifer D. Lewis, Eliza C. Martin, Karl J. Schreiber

Publikováno v: The Plant Journal. 101:352-370

NLR (Nucleotide-binding [NB] Leucine-rich repeat [LRR] Receptor) proteins are critical for inducing immune responses in response to pathogen proteins, and must be tightly regulated to prevent spurious activation in the absence of a pathogen. The ZAR1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bf43ac4b515a2cda210d6a6f3b58f3
https://doi.org/10.1111/tpj.14547

Transposon Molecular Domestication and the Evolution of the RAG Recombinase

Autor: Tat Cheung Cheng, Andrei J. Petrescu, Anlong Xu, Yong Xiong, Pierre Pontarotti, Qingyi Lu, Yuhang Zhang, David G. Schatz, Marius Surleac, Jeffrey D. Mandell, Guangrui Huang

Publikováno v: Nature
Nature, 2019, 569 (7754), pp.79-84. ⟨10.1038/s41586-019-1093-7⟩
Trends Immunol
Nature, Nature Publishing Group, 2019, 569 (7754), pp.79-84. ⟨10.1038/s41586-019-1093-7⟩

Domestication of a transposon (a DNA sequence that can change its position in a genome) to give rise to the RAG1–RAG2 recombinase (RAG) and V(D)J recombination, which produces the diverse repertoire of antibodies and T cell receptors, was a pivotal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d475b25d5d9a4c97a78453102f196a0d
http://europepmc.org/articles/PMC6494689

Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin

Autor: Andrei J. Petrescu, Pierre Pontarotti, Louis Tsakou-Ngouafo, Celia Vicari, Eliza C. Martin, David G. Schatz

Publikováno v: Mobile DNA
Mobile DNA, BioMed Central, 2020, 11 (1), ⟨10.1186/s13100-020-00214-y⟩
Mobile DNA, Vol 11, Iss 1, Pp 1-20 (2020)
Mobile DNA, 2020, 11 (1), ⟨10.1186/s13100-020-00214-y⟩

Background V(D) J recombination is essential for adaptive immunity in jawed vertebrates and is initiated by the RAG1-RAG2 endonuclease. The RAG1 and RAG2 genes are thought to have evolved from a RAGL (RAG-like) transposon containing convergently-orie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a34313a8adc3164ef7390e52d6135e0
https://hal.archives-ouvertes.fr/hal-03047226