Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Andrei I, Tarasov"'
Autor:
Elizabeth Haythorne, Matthew Lloyd, John Walsby-Tickle, Andrei I. Tarasov, Jonas Sandbrink, Idoia Portillo, Raul Terron Exposito, Gregor Sachse, Malgorzata Cyranka, Maria Rohm, Patrik Rorsman, James McCullagh, Frances M. Ashcroft
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Chronic hyperglycemia impairs insulin secretion from pancreatic beta cells in diabetes. Here, the authors reveal that a glucose metabolite is responsible and show lowering glucose metabolism during hyperglycemia prevents loss of beta-cell function.
Externí odkaz:
https://doaj.org/article/0ffc4770f495445c90f47a4eeab0f02b
Autor:
Christos E. Zois, Anne M. Hendriks, Syed Haider, Elisabete Pires, Esther Bridges, Dimitra Kalamida, Dimitrios Voukantsis, B. Christoffer Lagerholm, Rudolf S. N. Fehrmann, Wilfred F. A. den Dunnen, Andrei I. Tarasov, Otto Baba, John Morris, Francesca M. Buffa, James S. O. McCullagh, Mathilde Jalving, Adrian L. Harris
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-15 (2022)
Abstract Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions. We aimed to dissect the role of glycogen degradation in glioblastoma (GBM) res
Externí odkaz:
https://doaj.org/article/b1ef617fb3104ffda4ec574e955e7b3f
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/d3219a927e2c4b1ba590b7fb88c8644b
Autor:
Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F. Brereton, Andrei I. Tarasov, Thomas S. Blacker, Gregor Sachse, Mariana Silva dos Santos, Raul Terron Exposito, Simon Davis, Otto Baba, Roman Fischer, Michael R. Duchen, Patrik Rorsman, James I. MacRae, Frances M. Ashcroft
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a
Externí odkaz:
https://doaj.org/article/e58a88780c484df287e145eadffc1041
Autor:
Caroline M. Gorvin, Angela Rogers, Benoit Hastoy, Andrei I. Tarasov, Morten Frost, Silvia Sposini, Asuka Inoue, Michael P. Whyte, Patrik Rorsman, Aylin C. Hanyaloglu, Gerda E. Breitwieser, Rajesh V. Thakker
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 1054-1066 (2018)
Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles
Externí odkaz:
https://doaj.org/article/a620aa50861b4760af796663dffcd895
Autor:
Dipak Sarnobat, Ryan A Lafferty, R Charlotte Moffett, Andrei I Tarasov, Peter R Flatt, Nigel Irwin
Publikováno v:
Journal of Pharmacy and Pharmacology. 74:1758-1764
Objectives The antimalarial drug artemether is suggested to effect pancreatic islet cell transdifferentiation, presumably through activation γ-aminobutyric acid receptors, but this biological action is contested. Methods We have investigated changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35bde8caa538348818407fb93f8e6a2
https://doi.org/10.1093/jpp/rgac075
https://doi.org/10.1093/jpp/rgac075
Autor:
Julie Adam, Reshma Ramracheya, Margarita V. Chibalina, Nicola Ternette, Alexander Hamilton, Andrei I. Tarasov, Quan Zhang, Eduardo Rebelato, Nils J.G. Rorsman, Rafael Martín-del-Río, Amy Lewis, Gizem Özkan, Hyun Woong Do, Peter Spégel, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Benedikt M. Kessler, Christopher W. Pugh, Jorge Tamarit-Rodriguez, Hindrik Mulder, Anne Clark, Norma Frizzell, Tomoyoshi Soga, Frances M. Ashcroft, Andrew Silver, Patrick J. Pollard, Patrik Rorsman
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3135-3148 (2017)
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intoleran
Externí odkaz:
https://doaj.org/article/05d52d7c48f340449106e32e0dd4ebf7
Publikováno v:
Journal of Imaging, Vol 7, Iss 1, p 9 (2021)
Biological tissue consists of populations of cells exhibiting different responses to pharmacological stimuli. To probe the heterogeneity of cell function, we propose a multiplexed approach based on real‐time imaging of the secondary messenger level
Externí odkaz:
https://doaj.org/article/3cfd886d8291400d9b0f143cb87e1e78
Autor:
Dipak Sarnobat, R. Charlotte Moffett, Jinfang Ma, Peter R. Flatt, Neville H. McClenaghan, Andrei I. Tarasov
Publikováno v:
BioFactors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3869b5ed168431f92f8fce5f6a678943
https://doi.org/10.1002/biof.1938
https://doi.org/10.1002/biof.1938
Autor:
John N. Koberstein, Melissa L. Stewart, Chadwick B. Smith, Andrei I. Tarasov, Frances M. Ashcroft, Philip J. S. Stork, Richard H. Goodman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(31)
Cellular metabolism is regulated over space and time to ensure that energy production is efficiently matched with consumption. Fluorescent biosensors are useful tools for studying metabolism as they enable real-time detection of metabolite abundance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42491646d9d978e75e6a7026a467c89c
https://pubmed.ncbi.nlm.nih.gov/35881794
https://pubmed.ncbi.nlm.nih.gov/35881794