Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andrei Glinka"'
BMP signalling plays key roles in development, stem cells, adult tissue homeostasis, and disease. How BMP receptors are extracellularly modulated and in which physiological context, is therefore of prime importance. R-spondins (RSPOs) are a small fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32be66c4147a4defa5979b97c8b02dd6
https://doi.org/10.1101/2020.09.10.287607
https://doi.org/10.1101/2020.09.10.287607
Publikováno v:
Developmental Cell. 20:303-314
Summary The R-Spondin ( Rspo ) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48a60a44b02a57b0da6c174421e6753
https://doi.org/10.1016/j.devcel.2011.01.006
https://doi.org/10.1016/j.devcel.2011.01.006
R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis
Autor:
Ivan del Barco Barrantes, Peter Stannek, Christof Niehrs, Andrei Glinka, Wei Wu, Olga Kazanskaya
Publikováno v:
Developmental Cell. 7:525-534
We have carried out a small pool expression screen for modulators of the Wnt/beta-catenin pathway and identified Xenopus R-spondin2 (Rspo2) as a secreted activator of this cascade. Rspo2 is coexpressed with and positively regulated by Wnt signals and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27d6433e0729dc56d7adfe2132d5c41
https://doi.org/10.1016/j.devcel.2004.07.019
https://doi.org/10.1016/j.devcel.2004.07.019
Autor:
Andrei Glinka, Lan Chen, Christof Niehrs, Juan Carlos Izpisua Belmonte, Svetlana Shtrom, Concepción Rodríguez-Esteban, Sing Ping Huang, David W. Dorward, Lauren Gomer, Alexander Grinberg, Mahua Mukhopadhyay, Heiner Westphal, Tohru Tsukui
Publikováno v:
Developmental Cell. 1(3):423-434
Dickkopf1 (Dkk1) is a secreted protein that acts as a Wnt inhibitor and, together with BMP inhibitors, is able to induce the formation of ectopic heads in Xenopus. Here, we show that Dkk1 null mutant embryos lack head structures anterior of the midbr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c370367a73fe5bd200bb83f4845a018e
Publikováno v:
Current Biology. 10(24):1611-1614
Wnts are secreted glycoproteins implicated in diverse processes during embryonic patterning in metazoans. They signal through seven-transmembrane receptors of the Frizzled (Fz) family [1] to stabilise β -catenin [2]. Wnts are antagonised by several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866b861a1b390db244f8786b09fe94ae
Publikováno v:
Mechanisms of Development. 94:37-46
Zebrafish one-eyed pinhead (oep) is essential for embryonic axis and dorsal midline formation by promoting Nodal signalling and is thought to act as a permissive factor. Here we describe that oep elicits profound phenotypic effects when overexpressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34c6e329c3c08e3dc672d3e4ec11a43
https://doi.org/10.1016/s0925-4773(00)00329-4
https://doi.org/10.1016/s0925-4773(00)00329-4
Autor:
Michael Boutros, Cristina Maria Cruciat, Andrei Glinka, Christof Niehrs, Christine Dolde, Nadine Kirsch, Ya Lin Huang, Dierk Ingelfinger, Olga Kazanskaya
R-spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose mechanism of action is poorly understood. Here we show that R-spondins bind to the orphan G-protein-coupled receptors LGR4 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f973da4757182fcc9aec9944887df8e9
https://europepmc.org/articles/PMC3185347/
https://europepmc.org/articles/PMC3185347/
Publikováno v:
Nature. 389:517-519
The Spemann organizer of the amphibian embryo can be subdivided into two discrete activities, namely trunk organizer and head organizer1. Several factors secreted from the organizer that are involved in trunk organization are thought to act by repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97415aa21e2d047e7f36efdbefcd6600
https://doi.org/10.1038/39092
https://doi.org/10.1038/39092
Autor:
Christof Niehrs, Ursula Fenger, Josipa Bilic, Gary Davidson, Peter Stannek, Andrei Glinka, Jinlong Shen, Wei Wu
Publikováno v:
Nature. 438(7069)
Signalling by Wnt proteins (Wingless in Drosophila) has diverse roles during embryonic development and in adults, and is implicated in human diseases, including cancer. LDL-receptor-related proteins 5 and 6 (LRP5 and LRP6; Arrow in Drosophila) are ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee2683237691290c11d1421250ac952
https://pubmed.ncbi.nlm.nih.gov/16340998
https://pubmed.ncbi.nlm.nih.gov/16340998
Autor:
Christof Niehrs, Wei Wu, Peter Stannek, Joachim Marhold, Carmen Walter, Hajo Delius, Gary Davidson, Dana Hoppe, Bernard M. Mechler, Bingyu Mao, Mingfa Li, Andrei Glinka
Publikováno v:
Nature. 417(6889)
The Wnt family of secreted glycoproteins mediate cell cell interactions during cell growth and differentiation in both embryos and adults. Canonical Wnt signalling by way of the beta-catenin pathway is transduced by two receptor families. Frizzled pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de15250146f0142a336c7696aef77a5
https://pubmed.ncbi.nlm.nih.gov/12050670
https://pubmed.ncbi.nlm.nih.gov/12050670