Výsledky vyhledávání - "Andrei Alexandru Constantinescu"

Akademický článek

Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency

Autor: Hanene Belkahla, Andrei Alexandru Constantinescu, Tijani Gharbi, Florent Barbault, Alexandre Chevillot-Biraud, Philippe Decorse, Olivier Micheau, Miryana Hémadi, Souad Ammar

Publikováno v: Nanomaterials, Vol 11, Iss 2, p 502 (2021)

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing

Externí odkaz: https://doaj.org/article/22d6d7876dd046909e08e728f6de3c41

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Coupling tumor necrosis factor‐related apoptosis‐inducing ligand to iron oxide nanoparticles increases its apoptotic activity on HCT116 and HepG2 malignant cells: effect of magnetic core size

Autor: Alexander Revzin, Andrei Alexandru Constantinescu, Miryana Hémadi, Souad Ammar, Hanene Belkahla, Tijani Gharbi, Amranul Haque, Olivier Micheau

Publikováno v: Journal of Interdisciplinary Nanomedicine
Journal of Interdisciplinary Nanomedicine, 2019, 4 (1), pp.34-50. ⟨10.1002/jin2.55⟩

International audience; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered as a potential anticancer agent owing to its selectivity for malignant cells. However, its clinical use remains limited because of its poor ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c150c0a0763ec6dd0fdaa49f965a1e7c
https://www.hal.inserm.fr/inserm-03516760/document

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β cell membrane remodelling and procoagulant events occur in inflammation‐driven insulin impairment: a GLP ‐1 receptor dependent and independent control

Autor: Céline Gleizes, Guillaume Kreutter, Mohamad Kassem, Malak Abbas, Andrei Alexandru Constantinescu, Laurence Kessler, Julie Boisramé-Helms, Blandine Yver, Florence Toti

Publikováno v: Journal of Cellular and Molecular Medicine

Inflammation and hyperglycaemia are associated with a prothrombotic state. Cell‐derived microparticles (MPs) are the conveyors of active procoagulant tissue factor (TF) and circulate at high concentration in diabetic patients. Liraglutide, a glucag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ecd0f2939bd7acc802504871436ed3
https://doi.org/10.1111/jcmm.12683

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Immunoprecipitation of Death Inducing Signaling Complex by Caspase-8

Autor: Andrei Alexandru, Constantinescu, Aymeric, Morlé, Olivier, Micheau

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1557

Analysis of CD95/Fas complexes by immunoprecipitation has long relied on the monoclonal antibody APO1 or tagged recombinant Fas ligand. Immunoprecipitation is an elegant and efficient procedure to investigate endogenous protein interactions or comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d82efafbe9ef08e57baff1b970f7ff4
https://pubmed.ncbi.nlm.nih.gov/28247335

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Early assessment of glucose abnormalities during continuous glucose monitoring associated with lung function impairment in cystic fibrosis patients

Autor: Laurence Weiss, V. Rosner, François Moreau, B. Gauthier, Laurence Kessler, A. Leclercq, Romain Kessler, Andrei Alexandru Constantinescu

Publikováno v: Journal of Cystic Fibrosis. 13:478-484

Background: Cystic fibrosis-related diabetes (CFRD) is correlated with a decline in lung function. Under certain circumstances, oral glucose tolerance test (OGTT) screening, used to diagnose CFRD, fails to reveal early glucose tolerance abnormalities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf77b9d1c2f945156758562171d6136
https://doi.org/10.1016/j.jcf.2013.11.005

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Liraglutide protects Rin-m5f β cells by reducing procoagulant tissue factor activity and apoptosis prompted by microparticles under conditions mimicking Instant Blood-Mediated Inflammatory Reaction

Autor: Florence Toti, Malak Abbas, Laurence Kessler, Céline Gleizes, Andrei Alexandru Constantinescu, Fatiha Zobairi, Houda Bouhadja

Publikováno v: Transplant International. 27:733-740

Instant Blood-Mediated Inflammatory Reaction (IBMIR) occurs at the vicinity of transplanted islets immediately after intraportal infusion and is characterized by cytokine secretion, tissue factor (TF) expression, and s cell loss. Microparticles (MPs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b850e8bc6ef7cfb5515b0647a67898a9
https://doi.org/10.1111/tri.12286

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Exocrine cell-derived microparticles in response to lipopolysaccharide promote endocrine dysfunction in cystic fibrosis

Autor: Elhassan Yala, Ioan Liviu Mitrea, Andrei Alexandru Constantinescu, Céline Gleizes, Gheorghe Stoian, Florence Toti, Laurence Kessler, Mahmoud Alhosin, Gilles Prévost, Fatiha Zobairi, Alexandre Leclercq

Publikováno v: Journal of Cystic Fibrosis. 13(2):219-226

Background: Diabetes in cystic fibrosis (CF) is a result of exocrine pancreas alteration followed by endocrine dysfunction at a later stage. Microparticles (MPs) are plasma membrane fragments shed from stimulated or damaged cells that act as cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32aa77dec84698687268b237b25e10d

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Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells

Autor: Guillaume Kreutter, Céline Gleizes, Andrei Alexandru Constantinescu, Malak Abbas, Valérie B. Schini-Kerth, F. Toti, Laurence Kessler, Mohamad Kassem, Ioan Liviu Mitrea

Publikováno v: Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry, Springer Verlag, 2016, 418 (1-2), pp.91-102. ⟨10.1007/s11010-016-2736-8⟩
Molecular and Cellular Biochemistry, Springer Verlag, 2016, 418 (1-2), pp.91-102. 〈http://link.springer.com/article/10.1007%2Fs11010-016-2736-8〉. 〈10.1007/s11010-016-2736-8〉

International audience; To examine and compare the mitochondria-related cellular mechanisms by which tacrolimus (TAC) or sirolimus (SIR) immunosuppressive drugs alter the pancreatic exocrine and endocrine beta-cell fate. Human exocrine PANC-1 and rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58321805c61b52c4bd30d99c3fb86aa
https://pubmed.ncbi.nlm.nih.gov/27344165

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P174 Les microparticules produites par les monocytes en réponse à un stress infectieux altèrent la fonction de la cellule à insuline dans la mucoviscidose

Autor: Andrei Alexandru Constantinescu, Florence Toti, Céline Gleizes, Fatiha Zobairi, Laurence Kessler

Publikováno v: Diabetes & Metabolism. 40:A69-A70

Introduction Des travaux anterieurs ont demontre l’effet deletere de microparticules (MPs) pancreatiques exocrines sur les cellules a insuline en absence d’expression de CFTR. Le but du present travail etait d’etudier le role des MPs monocytair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c43d15d826ff0a70a586e137a2ec9c63
https://doi.org/10.1016/s1262-3636(14)72465-6

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Studying the aging of banked erythrocytes using a fluorescence marker, hypericin

Autor: Andrei Alexandru Constantinescu, Maria Dobreanu, George Popoiu, Andrei Tanase, Cristina Sturzoiu

Publikováno v: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara, Vol 11, Iss 4 (2010)

Banked blood used for transfusions can be banked for 42 days, but there are several issues that can make it unusable: biochemical and biomechanical changes that leads to storage lesions of erythrocytes. These changes can cause multiple health problem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::ed1cf5ef2d9b59a6b4678a3930a91d6e
http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/819

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