Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Andrei A. Gilep"'
Autor:
Alexey V. Kuzikov, Rami A. Masamrekh, Tatiana A. Filippova, Anastasiya M. Tumilovich, Natallia V. Strushkevich, Andrei A. Gilep, Yulia Yu. Khudoklinova, Victoria V. Shumyantseva
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 152 (2024)
We describe a bielectrode system for evaluation of the electrocatalytic activity of cytochrome P450 2E1 (CYP2E1) towards chlorzoxazone. One electrode of the system was employed to immobilize Bactosomes with human CYP2E1, cytochrome P450 reductase (CP
Externí odkaz:
https://doaj.org/article/9be09772c041412986e3ecb53905337b
Autor:
Tatsiana V. Tsybruk, Leonid A. Kaluzhskiy, Yuri V. Mezentsev, Tatyana N. Makarieva, Kseniya M. Tabakmaher, Natalia V. Ivanchina, Pavel S. Dmitrenok, Alexander V. Baranovsky, Andrei A. Gilep, Alexis S. Ivanov
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2873 (2023)
Due to the increasing prevalence of fungal diseases caused by fungi of the genus Candida and the development of pathogen resistance to available drugs, the need to find new effective antifungal agents has increased. Azole antifungals, which are inhib
Externí odkaz:
https://doaj.org/article/2405999c00fc4866a1202feaf5e17b59
Autor:
Polina I. Koroleva, Andrei A. Gilep, Sergey V. Kraevsky, Tatiana V. Tsybruk, Victoria V. Shumyantseva
Publikováno v:
Biosensors, Vol 13, Iss 4, p 457 (2023)
In the present work, screen-printed electrodes (SPE) modified with a synthetic surfactant, didodecyldimethylammonium bromide (DDAB) and streptolysin O (SLO) were prepared for cytochrome P450 3A4 (CYP3A4) immobilization, direct non-catalytic and catal
Externí odkaz:
https://doaj.org/article/c8364465c1f2433e91bdc428db511bfb
Autor:
Cristina Rodriguez‐Antona, Jessica L. Savieo, Volker M. Lauschke, Katrin Sangkuhl, Britt I. Drögemöller, Danxin Wang, Ron H. N. van Schaik, Andrei A. Gilep, Arul P. Peter, Erin C. Boone, Bronwyn E. Ramey, Teri E. Klein, Michelle Whirl‐Carrillo, Victoria M. Pratt, Andrea Gaedigk
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:1159-1171
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus impacts the metabolism of several clinically important drugs, including the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b850582462fe0001640da5796eadb7
https://doi.org/10.1002/cpt.2563
https://doi.org/10.1002/cpt.2563
Autor:
Wolfram Tempel, Irina Grabovec, Farrell MacKenzie, Yaroslav V. Dichenko, Sergey A. Usanov, Andrei A. Gilep, Hee-Won Park, Natallia Strushkevich
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1925-1932 (2014)
Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol. To identify the structura
Externí odkaz:
https://doaj.org/article/d9f4e2677f5a4e7b996e9e894a97ed20
Autor:
Pavel V. Ershov, Yuri V. Mezentsev, Arthur T. Kopylov, Evgeniy O. Yablokov, Andrey V. Svirid, Aliaksandr Ya. Lushchyk, Leonid A. Kaluzhskiy, Andrei A. Gilep, Sergey A. Usanov, Alexey E. Medvedev, Alexis S. Ivanov
Publikováno v:
Biology, Vol 8, Iss 2, p 49 (2019)
Prostacyclin synthase (PTGIS; EC 5.3.99.4) catalyzes isomerization of prostaglandin H2 to prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. At present, limited data exist on functional coupling and possible ways of regulating
Externí odkaz:
https://doaj.org/article/7c46b9e2b62d4e7d923f8b00dca1f146
Autor:
Victoria V. Shumyantseva, Polina I. Koroleva, Tatiana V. Bulko, Tatyana V. Shkel, Andrei A. Gilep, Alexander V. Veselovsky
Publikováno v:
Bioelectrochemistry (Amsterdam, Netherlands). 149
The electrochemically driven cytochrome P450 reactions have great promise as drug sensing device, new drug searching tool and bioreactor with broad synthetic application. In the present work, we proposed approaches for the increasing the efficiency o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9637ea6b6e3993d8501cad6576a2625f
https://pubmed.ncbi.nlm.nih.gov/36198256
https://pubmed.ncbi.nlm.nih.gov/36198256
Autor:
Victoria V. Shumyantseva, Tatiana V. Bulko, Polina I. Koroleva, Evgeniya V. Shikh, Anna A. Makhova, Maryia S. Kisel, Irina V. Haidukevich, Andrei A. Gilep
Publikováno v:
Processes; Volume 10; Issue 2; Pages: 383
The electrochemical properties of cytochrome P450 2C9 (CYP2C9) and polymorphic modifications P450 2C9*2 (CYP2C9*2) and P450 2C9*3 (CYP2C9*3) were studied. To analyze the comparative electrochemical and electrocatalytic activity, the enzymes were immo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d2a4b3d76dc95a9d7b3dc8af2f8411
Autor:
Victoria V. Shumyantseva, Rami A. Masamrekh, Andrew Ivanov, Alexey V. Kuzikov, Sergey A. Usanov, Yuri Mezentsev, P V Ershov, Andrei A. Gilep
Publikováno v:
BioNanoScience. 10:157-167
In the present study, the effects of endogenous non-peptide bioregulator isatin (indole-2,3-dione) cytochrome P450 isoenzymes 3A5, 3A4, 2C19, 2E1, and 5A1 were investigated for the first time by means of electrochemical methods. Absorption spectrosco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7eca78a38533c0546d82d649e76c369
https://doi.org/10.1007/s12668-019-00707-y
https://doi.org/10.1007/s12668-019-00707-y
Autor:
Andrei A. Gilep, Alexander V. Dmitriev, Natallia Strushkevich, Yaraslau I. Haurychenka, Victoria V. Shumyantseva, Rami A. Masamrekh, T. V. Shkel, Alexander V. Veselovsky, Maria G. Zavialova, Alexey V. Kuzikov, Dmitrii Filimonov, Kirill Shcherbakov, Sergey A. Usanov, Alexander I. Archakov
Publikováno v:
Fundamental & Clinical Pharmacology. 34:120-130
Potential drug-drug interactions of the antitumor drug abiraterone and the macrolide antibiotic erythromycin were studied at the stage of cytochrome P450 3A4 (CYP3A4) biotransformation. Using differential spectroscopy, we have shown that abiraterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71615d211a32cc1986582c0717ca35be
https://doi.org/10.1111/fcp.12497
https://doi.org/10.1111/fcp.12497