Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrei, Ursu"'
Publikováno v:
Inducing Targeted Protein Degradation. :245-272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2db71125af45ac68f1164a4ea68a88f
https://doi.org/10.1002/9783527836208.ch9
https://doi.org/10.1002/9783527836208.ch9
Autor:
Damir Jacob Illich, Miao Zhang, Andrei Ursu, Rodrigo Osorno, Kee-Pyo Kim, Juyong Yoon, Marcos J. Araúzo-Bravo, Guangming Wu, Daniel Esch, Davood Sabour, Douglas Colby, Kathrin S. Grassme, Jiayu Chen, Boris Greber, Susanne Höing, Wiebke Herzog, Slava Ziegler, Ian Chambers, Shaorong Gao, Herbert Waldmann, Hans R. Schöler
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 787-800 (2016)
It has previously been reported that mouse epiblast stem cell (EpiSC) lines comprise heterogeneous cell populations that are functionally equivalent to cells of either early- or late-stage postimplantation development. So far, the establishment of th
Externí odkaz:
https://doaj.org/article/bcd0b9b6536d410aacc68d28af505701
Autor:
Samantha M. Meyer, Collin A. O’Leary, Jessica L. Childs-Disney, Andrei Ursu, Alicia J. Angelbello, Walter N. Moss, Matthew D. Disney, Ryan J. Andrews
Publikováno v:
Chem Soc Rev
The design and discovery of small molecule medicines has largely been focused on a small number of druggable protein families. A new paradigm is emerging, however, in which small molecules exert a biological effect by interacting with RNA, both to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3a566f2e73b2c6a3f73383bd4b0fa5
https://doi.org/10.1039/d0cs00455c
https://doi.org/10.1039/d0cs00455c
Autor:
Jeffrey D. Rothstein, Jonathan L. Chen, Montina Van Meter, Tania F. Gendron, Alyssa N. Coyne, Yong Jie Zhang, Eric T. Wang, Yue Li, Ilyas Yildirim, Rita Fuerst, Jessica A. Bush, Leonard Petrucelli, Samantha M. Meyer, Hailey Olafson, Jessica L. Childs-Disney, Kye Won Wang, Yuquan Tong, Kendra K. McKee, Raphael I. Benhamou, Tanya Khan, Andrei Ursu, Matthew D. Disney, Sarah Wagner-Griffin, Haruo Aikawa
Publikováno v:
Sci Transl Med
The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD) is an expanded G(4)C(2) RNA repeat [r(G(4)C(2))(exp)] in chromosome 9 open reading frame 72 (C9orf72), which elicits pathology through several mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c7323437f11575a5a155e154c7f4b4
https://europepmc.org/articles/PMC9533739/
https://europepmc.org/articles/PMC9533739/
Autor:
Jessica A. Bush, Andrei Ursu, Amirhossein Taghavi, Matthew D. Disney, Shruti Choudhary, Leonard Petrucelli, Yong Jie Zhang, Jared T. Baisden, Ilyas Yildirim, Tania F. Gendron
Publikováno v:
ACS Chem Neurosci
The hexanucleotide repeat expansion GGGGCC [r(G(4)C(2))(exp)] within intron 1 of C9orf72 causes genetically defined amyotrophic lateral sclerosis and frontotemporal dementia, collectively named c9ALS/FTD. , the repeat expansion causes neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9862d533df9726819e1b4bdf5dd074d
https://europepmc.org/articles/PMC9594102/
https://europepmc.org/articles/PMC9594102/
Publikováno v:
Drug Discov Today
RNAs, particularly noncoding RNAs (ncRNAs), are becoming increasingly important therapeutic targets, because they are causative and antagonists of human disease. Indeed, aberrant RNA structural elements and expression deregulate biological processes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ee90cc4f6b5cc93e33f0e7c18a9157
https://doi.org/10.1016/j.drudis.2019.06.019
https://doi.org/10.1016/j.drudis.2019.06.019
Autor:
Andrei Ursu, Tania F. Gendron, Ilyas Yildirim, Kye Won Wang, Jonathan L. Chen, Shruti Choudhary, Jessica A. Bush, Jared T. Baisden, Yong Jie Zhang, Matthew D. Disney, Leonard Petrucelli
Publikováno v:
ACS Chem Biol
Genetically defined amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), collectively named c9ALS/FTD, are triggered by hexanucleotide GGGGCC repeat expansions [r(G(4)C(2))(exp)] within the C9orf 72 gene. In these diseases, neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f762602cbb53f59742e372efb331d8
https://pubmed.ncbi.nlm.nih.gov/33196168
https://pubmed.ncbi.nlm.nih.gov/33196168
Publikováno v:
Protein Degradation with New Chemical Modalities ISBN: 9781788016865
Small-molecule targeting of structural elements within disease-causing RNAs has garnered the interest of academia and the pharmaceutical industry. This chapter describes advances in the targeted degradation of RNA by structure-specific synthetic liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017bc81af54bc38e6fca98ada9a43d36
https://doi.org/10.1039/9781839160691-00317
https://doi.org/10.1039/9781839160691-00317
Autor:
Samantha M. Meyer, Andrei Ursu, Jessica L. Childs-Disney, Alicia J. Angelbello, Matthew G. Costales, Matthew D. Disney
Publikováno v:
ACS Chem Biol
Selectivity is a key requirement of high-quality chemical probes and lead medicines; however, methods to quantify and compare the selectivity of small molecules have not been standardized across the field. Herein, we discuss the origins and use of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82feba561082da86373ec916b032584
https://pubmed.ncbi.nlm.nih.gov/32568503
https://pubmed.ncbi.nlm.nih.gov/32568503
Autor:
Andrei Ursu, Hans R. Schöler, Herbert Waldmann, Andreas Hochheimer, Jan M. Bruder, Alexandra Friese
Publikováno v:
Cell Chemical Biology
Recent advances in induced pluripotent stem cell technologies and phenotypic screening shape the future of bioactive small-molecule discovery. In this review we analyze the impact of small-molecule phenotypic screens on drug discovery as well as on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff325178a52883e924dd83c7be6b4e22
https://hdl.handle.net/21.11116/0000-0003-DCD8-221.11116/0000-0003-DCDA-0
https://hdl.handle.net/21.11116/0000-0003-DCD8-221.11116/0000-0003-DCDA-0