Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Andrei, Goga"'
Autor:
Mauricio Jacobo Jacobo, Hayley J. Donnella, Sushil Sobti, Swati Kaushik, Andrei Goga, Sourav Bandyopadhyay
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Individual cancers are composed of heterogeneous tumor cells with distinct phenotypes and genotypes, with triple negative breast cancers (TNBC) demonstrating the most heterogeneity among breast cancer types. Variability in transcriptional ph
Externí odkaz:
https://doaj.org/article/54547d28190b4392a930f8ef09f1e6a6
Autor:
Tuomo J Meretoja, Ruixian Liu, Diether Lambrechts, Johanna Mattson, Satu Mustjoki, Päivi Saavalainen, Bram Boeckx, Maija Hollmen, Rita Turpin, Pauliina M Munne, Aino Peura, Jenna H Rannikko, Gino Philips, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova, July Aung, Elisa M Vuorinen, Laura Lehtinen, Minna Mutka, Panu E Kovanen, Laura Niinikoski, Andrei Goga, Jeroen Pouwels, Juha Klefström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on the tumor immune microenvironment (TIME). Therefore, there is a c
Externí odkaz:
https://doaj.org/article/cffa2828cea442bea9cecbc2dda3a9f7
Autor:
Renaldo Sutanto, Lila Neahring, Andrea Serra Marques, Mauricio Jacobo Jacobo, Seda Kilinc, Andrei Goga, Sophie Dumont
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0296779 (2024)
The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function, par
Externí odkaz:
https://doaj.org/article/4c1d28d584b9491e9a559c6f02e9e6be
Autor:
Niantao Deng, Andre Minoche, Kate Harvey, Meng Li, Juliane Winkler, Andrei Goga, Alex Swarbrick
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Breast cancer cell lines (BCCLs) and patient-derived xenografts (PDXs) are the most frequently used models in breast cancer research. Despite their widespread usage, genome sequencing of these models is incomplete, with previous s
Externí odkaz:
https://doaj.org/article/10b7803de6574e2a900f1190e872c4f4
Autor:
Joyce V. Lee, Filomena Housley, Christina Yau, Rachel Nakagawa, Juliane Winkler, Johanna M. Anttila, Pauliina M. Munne, Mariel Savelius, Kathleen E. Houlahan, Daniel Van de Mark, Golzar Hemmati, Grace A. Hernandez, Yibing Zhang, Susan Samson, Carole Baas, Laura J. Esserman, Laura J. van ‘t Veer, Hope S. Rugo, Christina Curtis, Juha Klefström, Mehrdad Matloubian, Andrei Goga
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The oncoprotein c-Myc is often overexpressed in triple negative breast cancer and has a role in tumor progression and resistance to therapy. Here the authors show that elevated MYC expression is correlated with low immune infiltration, diminished MHC
Externí odkaz:
https://doaj.org/article/5ba305a5a1f9497c9247af3f00c75bef
Autor:
Neelima Vidula, Sally Greenberg, Laura Petrillo, Jimmy Hwang, Michelle Melisko, Andrei Goga, Mark Moasser, Mark Magbanua, John W. Park, Hope S. Rugo
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-6 (2021)
Abstract We evaluated disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) in patients with stage I-III breast cancer with >4 MM/mL DTC at baseline who received adjuvant zoledronic acid (ZOL). ZOL was administered every 4 weeks for 24 m
Externí odkaz:
https://doaj.org/article/3a9e793b4485485687e39189dbcf79b3
Autor:
Joyce V. Lee, Filomena Housley, Christina Yau, Rachel Nakagawa, Juliane Winkler, Johanna M. Anttila, Pauliina M. Munne, Mariel Savelius, Kathleen E. Houlahan, Daniel Van de Mark, Golzar Hemmati, Grace A. Hernandez, Yibing Zhang, Susan Samson, Carole Baas, Marleen Kok, Laura J. Esserman, Laura J. van ‘t Veer, Hope S. Rugo, Christina Curtis, Juha Klefström, Mehrdad Matloubian, Andrei Goga
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/c4c95fa626f54c138a7df8b82c363e2c
Autor:
Susan Samson, Jason J. Northey, Irene Acerbi, Andrei Goga, Carl L. Flink, Valerie M. Weaver, Mark A. LaBarge
Publikováno v:
Translational Oncology, Vol 16, Iss , Pp 101325- (2022)
Advocacy engagement has been at the forefront of National Cancer Institute (NCI) efforts to advance scientific discoveries and transform medical interventions. Nonetheless, the journey for advocates has been uneven. Case in Point: NCI publication aff
Externí odkaz:
https://doaj.org/article/83e8643e1fe0486e86d3440e66c57d7e
Autor:
Julia Rohrberg, Daniel Van de Mark, Meelad Amouzgar, Joyce V. Lee, Moufida Taileb, Alexandra Corella, Seda Kilinc, Jeremy Williams, Marie-Lena Jokisch, Roman Camarda, Sanjeev Balakrishnan, Rama Shankar, Alicia Zhou, Aaron N. Chang, Bin Chen, Hope S. Rugo, Sophie Dumont, Andrei Goga
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3368-3382.e7 (2020)
Summary: Tumors that overexpress the MYC oncogene are frequently aneuploid, a state associated with highly aggressive cancers and tumor evolution. However, how MYC causes aneuploidy is not well understood. Here, we show that MYC overexpression induce
Externí odkaz:
https://doaj.org/article/2a58f33465c64c2095456ecd5652ebd7
Autor:
Quy H. Nguyen, Nicholas Pervolarakis, Kerrigan Blake, Dennis Ma, Ryan Tevia Davis, Nathan James, Anh T. Phung, Elizabeth Willey, Raj Kumar, Eric Jabart, Ian Driver, Jason Rock, Andrei Goga, Seema A. Khan, Devon A. Lawson, Zena Werb, Kai Kessenbrock
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithe
Externí odkaz:
https://doaj.org/article/91b73d5c18954375862a70796e2fa7c2