Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Andreea Trache"'
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
The intima, comprising the endothelium and the subendothelial matrix, plays a crucial role in atherosclerosis pathogenesis. The mechanical stress arising from disturbed blood flow (d-flow) and the stiffening of the arterial wall contributes to endoth
Externí odkaz:
https://doaj.org/article/f169868cc3af404196e43a2826e4a408
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Stress fibers are actomyosin bundles that regulate cellular mechanosensation and force transduction. Interacting with the extracellular matrix through focal adhesion complexes, stress fibers are highly dynamic structures regulated by myosin
Externí odkaz:
https://doaj.org/article/aa75a1f7baee4b748defd3d9029c65a4
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/7995eff7bea045a295a7805175f327c2
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
A better understanding of endothelial dysfunction holds promise for more effective interventions for atherosclerosis prevention and treatment. Endothelial signaling by the non-catalytic region of the tyrosine kinase (NCK) family of adaptors, consisti
Externí odkaz:
https://doaj.org/article/bec7ced10a65427bbc5c3eece3659dd1
Autor:
Krishna R. Ojha, Hyoseon Kim, Samuel Padgham, Laura Hopkins, Robert J. Zamen, Abhijnan Chattopadhyay, Gang Han, Dianna M. Milewicz, Michael P. Massett, Andreea Trache
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9616 (2023)
Thoracic aortic aneurysm is found in patients with ACTA2 pathogenic variants. ACTA2 missense variants are associated with impaired aortic smooth muscle cell (SMC) contraction. This study tested the hypothesis that the Acta2R149C/+ variant alters acti
Externí odkaz:
https://doaj.org/article/cb2ac005c9654f7aa408ffa13665c3cb
Autor:
Krishna Raj Ojha, Song Yi Shin, Samuel Padgham, Frida Leon Olmedo, Bohong Guo, Gang Han, Christopher Woodman, Andreea Trache
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Arterial aging results in a progressive reduction in elasticity of the vessel wall and an impaired ability of aged blood vessels to control local blood flow and pressure. Recently, a new concept has emerged that the stiffness and decreased contractil
Externí odkaz:
https://doaj.org/article/f0743a6f5cbb42daa64f02e29099366b
Autor:
Xiaona Li, Qin Ni, Xiuxiu He, Jun Kong, Soon-Mi Lim, Garegin A Papoian, Jerome P Trzeciakowski, Andreea Trache, Yi Jiang
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007693 (2020)
Understanding cellular remodeling in response to mechanical stimuli is a critical step in elucidating mechanical activation of biochemical signaling pathways. Experimental evidence indicates that external stress-induced subcellular adaptation is acco
Externí odkaz:
https://doaj.org/article/925214784ef44ba496c305d032eba865
Autor:
John W. Seawright, Harini Sreenivasappa, Holly C. Gibbs, Samuel Padgham, Song Y. Shin, Christine Chaponnier, Alvin T. Yeh, Jerome P. Trzeciakowski, Christopher R. Woodman, Andreea Trache
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Aging induces a progressive decline in vasoconstrictor responses in central and peripheral arteries. This study investigated the hypothesis that vascular smooth muscle (VSM) contractile function declines with age in soleus muscle feed arteries (SFA).
Externí odkaz:
https://doaj.org/article/99e70e9dbc494fe4b0d756a1750f091c
Publikováno v:
Scientific Reports. 13
Stress fibers are actomyosin bundles that regulate cellular mechanosensation and force transduction. Interacting with the extracellular matrix through focal adhesion complexes, stress fibers are highly dynamic structures regulated by myosin motors an
Publikováno v:
Physiology. 38
Age–related impairments of skeletal muscle resistance arteries are associated with alterations in vascular smooth muscle cell (VSMC) contractility. Aerobic exercise is an effective intervention for reversing the impacts of aging on vascular contrac