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of 16
pro vyhledávání: '"Andree G. Pearson"'
Autor:
Andree G. Pearson, Juliet M. Pullar, John Cook, Emma S. Spencer, Margreet CM. Vissers, Anitra C. Carr, Mark B. Hampton
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101980- (2021)
Intravenous infusion of high dose (>10 g) vitamin C (IVC) is a common alternative cancer therapy. IVC results in millimolar levels of circulating ascorbate, which is proposed to generate cytotoxic quantities of H2O2 in the presence of transition meta
Externí odkaz:
https://doaj.org/article/7b9ed30450164947a618657be3e76d45
Autor:
Mark B. Hampton, Margreet C.M. Vissers, Andree G. Pearson, Emma Spencer, Anitra C. Carr, John D. Cook, Juliet M. Pullar
Publikováno v:
Redox Biology, Vol 43, Iss, Pp 101980-(2021)
Redox Biology
Redox Biology
Intravenous infusion of high dose (>10 g) vitamin C (IVC) is a common alternative cancer therapy. IVC results in millimolar levels of circulating ascorbate, which is proposed to generate cytotoxic quantities of H2O2 in the presence of transition meta
Publikováno v:
Free radical research. 54(4)
Improved technology for the bioenergetic profiling of human blood cells enables population-based screening for alterations in mitochondrial respiration. Mitochondria are sensitive to oxidative stress, and the aim of this study was to quantify mitocho
Autor:
Andree G. Pearson, Masuma Zawari, Greg F. Walker, Anitra C. Carr, Bettina Poller, Mark B. Hampton
Publikováno v:
Antioxidants
Volume 8
Issue 9
Antioxidants, Vol 8, Iss 9, p 359 (2019)
Volume 8
Issue 9
Antioxidants, Vol 8, Iss 9, p 359 (2019)
Broccoli sprout powder is a rich source of glucosinolates, which are hydrolysed to isothiocyanates in the presence of the enzyme myrosinase. We showed that in vitro incubation of broccoli sprout powder extract with isolated lymphocytes resulted in th
Autor:
Andrew G. Cox, W. Todd Lowther, Juliet M. Pullar, Mark B. Hampton, Christine C. Winterbourn, Andree G. Pearson, Thomas J. Jönsson
Publikováno v:
Biochemical Journal. 421:51-58
The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid formed during the catalytic cycle reacts with hydrogen peroxide. In the present study, Western b
Publikováno v:
Neuroscience Letters. 398:246-250
Alzheimer's disease (AD) pathology is characterized by the presence of insoluble beta-amyoid deposits and neurofibrillary tangles containing hyperphosphorylated tau. Increased expression of the immediate early gene product c-Jun has also been reporte
Autor:
Jeffrey M. Greenwood, Simon J. O'Carroll, Rachel Cameron, Hannah M. Gibbons, Mike Dragunow, Andree G. Pearson, Pritika Narayan
Publikováno v:
Neuroscience. 140:1149-1156
Valproic acid is widely used for the treatment of epilepsy and mood disorders, but its mode of action is unclear. Treatment of neuronal cells with valproic acid promotes neurite sprouting, is neuroprotective and drives neurogenesis; however its effec
Publikováno v:
Neuroscience. 133:437-451
Activating transcription factor 2 (ATF2) is a member of the activator protein-1 family of transcription factors, which includes c-Jun and c-Fos. ATF2 is highly expressed in the mammalian brain although little is known about its function in nerve cell
Publikováno v:
Free Radical Biology and Medicine. 100:S106
The peroxiredoxins (Prxs) are a family of thiol peroxidases that effectively reduce cellular hydroperoxides. Treatment of erythrocytes with hydrogen peroxide oxidizes their Prx 2, and we have previously shown that erythrocyte Prx 2 oxidation occurs i
Autor:
Alexander Muravlev, Mike Dragunow, Hannah M. Gibbons, P. Lawlor, Deborah Young, Ruian Xu, Andree G. Pearson, Janusz Lipski, Ann-Marie Woodgate, Matthew J. During, G.A. MacGibbon, M. Walton
Publikováno v:
Molecular Brain Research. 83:20-33
We investigated the function of c-Jun in PC12 cells by transfecting them with a plasmid containing a c-Jun cDNA transcription cassette. Transfected cells expressed high levels of c-Jun mRNA and protein and demonstrated an increase in both AP-1 DNA bi