Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andreas van de Locht"'
Autor:
Jerrold H. Levy, Kenichi A. Tanaka, Fania Szlam, Satoru Ogawa, Heezoo Kim, Andreas van de Locht
Publikováno v:
Anesthesia & Analgesia. 115:244-252
BACKGROUND The activated clotting time (ACT) is widely used for monitoring heparin anticoagulation during cardiac surgery. Celite-based ACT values are prolonged when aprotinin is administered. MDCO-2010, a novel serine protease inhibitor, is currentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3020567b9e1ade94c90c37380795b69
https://doi.org/10.1213/ane.0b013e3182576a5a
https://doi.org/10.1213/ane.0b013e3182576a5a
Autor:
Andreas van de Locht, Kerstin Uhland, Frauke Alves, Friedemann Müller, Jean Bernhard Petri, Christian Dullin, Torsten Steinmetzer, Joanna Napp
Publikováno v:
International Journal of Cancer. 127:1958-1974
Proteolytic enzymes expressed on the surface of tumor cells, and thus easily accessible to external interventions, represent useful targets for anticancer and antimetastatic therapies. In our study, we thoroughly evaluated matriptase, a trypsin-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ea95b1850960e6c3a2032be02b75fe
https://doi.org/10.1002/ijc.25405
https://doi.org/10.1002/ijc.25405
Autor:
Susanne Bährle, Matthias Karck, Andreas van de Locht, Humaira Haider, Nelli Krieger, Tamás Radovits, Gábor Veres, Silke Niklisch, Christiane Miesel-Gröschel, Gábor Szabó
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 139(3):732-740
BackgroundSerine protease inhibitors such as aprotinin reduce perioperative blood loss and may improve postpump cardiac performance owing to their anti-inflammatory properties. After the “aprotinin era,” we investigated the efficacy of the novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b25d847ac9355683409ee3851fc5b4
Autor:
Nelli Krieger, Gábor Szabó, Andreas van de Locht, Silke Niklisch, Christiane Miesel-Gröschel, Susanne Bährle, Gábor Veres, Tamás Radovits, Matthias Karck, Humaira Haider
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 139:181-188
ObjectiveAlthough aprotinin has been widely used to reduce perioperative blood loss after cardiopulmonary bypass, recent concerns have led to its withdrawal. This study investigated effects of the novel synthetic serine protease inhibitors CU-2010 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76f0de605bf8ac675a0df2856644eb1
https://doi.org/10.1016/j.jtcvs.2009.09.019
https://doi.org/10.1016/j.jtcvs.2009.09.019
CU-2010—A Novel Small Molecule Protease Inhibitor with Antifibrinolytic and Anticoagulant Properties
Autor:
Andreas Koster, Helmut Giersiefen, Wulf Dietrich, Andreas van de Locht, Silke Nicklisch, Michael Spannagl
Publikováno v:
Anesthesiology. 110:123-130
Background In cardiac surgery, the contact of blood with the artificial surfaces of the cardiopulmonary bypass results in activation of coagulation, fibrinolysis, and platelets, which is recognized as reason for increased bleeding tendency. Antifibri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dc87a1ac6d1c40e5e1dbb6417ad35a
https://doi.org/10.1097/aln.0b013e318191408c
https://doi.org/10.1097/aln.0b013e318191408c
Publikováno v:
Journal of Biological Chemistry. 271:3413-3416
The 2.6-A x-ray crystal structure of bovine α-thrombin in complex with rhodniin, a protein inhibitor isolated from the bug Rhodnius prolixus, has been solved and refined. The structure has enabled us to trace the N-terminal part of the 49-residue A-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977cf0f0dd2a9c3b8bc7734fa88cbcbb
https://doi.org/10.1074/jbc.271.7.3413
https://doi.org/10.1074/jbc.271.7.3413
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 26(1)
The development of serine protease inhibitors often results in the discovery of new lead compounds containing strong basic amidine functions that usually suffer from poor absorption from the intestine. In order to improve oral bioavailability of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cb28b1aa267640e6fb1d8867accf85
https://pubmed.ncbi.nlm.nih.gov/20583861
https://pubmed.ncbi.nlm.nih.gov/20583861
Autor:
Torsten Steinmetzer, Andreas van de Locht, Kerstin Uhland, Bence Siphos, Maj Schuster, Christoph Arkona, Bernhard Petri, Friedemann Mueller, Andrea Schweinitz, Peter Steinmetzer
Publikováno v:
International Journal of Oncology.
Matriptase, also known as MT-SP1, is a type II transmembrane serine protease strongly implicated in both the development and progression of a variety of epithelial cancers. Evidence comes from studies of its expression in human cancers and from mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0fb884998ad7e48dd11e8495fb6aec
https://doi.org/10.3892/ijo_00000346
https://doi.org/10.3892/ijo_00000346
Autor:
Hans Fritz, Milton T. Stubbs, Andreas van de Locht, Ennes A. Auerswald, Robert Morenweiser, Jörg Stürzebecher
Publikováno v:
The Journal of biological chemistry. 272(32)
Using the three-dimensional structures of thrombin and the leech-derived tryptase inhibitor (LDTI), which does not inhibit thrombin, we were able to construct three LDTI variants inhibiting thrombin. Trimming of the inhibitor reactive site loop to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4135cc36a4d32001f4ec2f1b0367e19
https://pubmed.ncbi.nlm.nih.gov/9242661
https://pubmed.ncbi.nlm.nih.gov/9242661
Autor:
Szabó, Gábor, Veres, Gábor, Radovits, Tamás, Haider, Humaira, Krieger, Nelli, Bährle, Susanne, Niklisch, Silke, Miesel-Gröschel, Christiane, van de Locht, Andreas, Karck, Matthias
Publikováno v:
In The Journal of Thoracic and Cardiovascular Surgery 2010 139(3):732-740