Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Andreas Wyttenbach"'
Autor:
Tiago F. Outeiro, Sarah Hands, Susanna Campesan, Edward W. Green, Federico Herrera, Flaviano Giorgini, Leonor Miller-Fleming, Andreas Wyttenbach, Muhammad U. Sajjad, Ali Khoshnan
Publikováno v:
Human Molecular Genetics. 23:755-766
The oxidation-sensitive chaperone protein DJ-1 has been implicated in several human disorders including cancer and neurodegenerative diseases. During neurodegeneration associated with protein misfolding, such as that observed in Alzheimer's disease a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab19bbac726b1e235f318f0fef868e94
https://doi.org/10.1093/hmg/ddt466
https://doi.org/10.1093/hmg/ddt466
Publikováno v:
Brain, Behavior, and Immunity
Highlight ► This work describes age related changes in microglial phenotype in different CNS regions and highlights differences between grey and white matter.
Subtle regional differences in microglial phenotype exist in the adult mouse brain.
Subtle regional differences in microglial phenotype exist in the adult mouse brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f3657d2e536e32085f94f71b7d2942
https://doi.org/10.1016/j.bbi.2011.11.006
https://doi.org/10.1016/j.bbi.2011.11.006
Publikováno v:
Journal of Biological Chemistry. 286:44512-44520
Neurodegenerative diseases are characterized by intra- and/or extracellular protein aggregation and oxidative stress. Intense attention has been paid to whether protein aggregation itself contributes to abnormal production of free radicals and ensuin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebf73aeed9c826f0c0802b4201ff532
https://doi.org/10.1074/jbc.m111.307587
https://doi.org/10.1074/jbc.m111.307587
Autor:
Sarah Hands, Andreas Wyttenbach
Publikováno v:
Acta Neuropathologica. 120:419-437
Polyglutamine (polyQ) diseases are associated with a CAG/polyQ expansion mutation in unrelated proteins. Upon elongation of the glutamine tract, disease proteins aggregate within cells, mainly in the central nervous system (CNS) and this aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cd317faa1d463156da74e35a3ab3f5
https://doi.org/10.1007/s00401-010-0703-0
https://doi.org/10.1007/s00401-010-0703-0
Publikováno v:
Aging
The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790f47f2a1cfb14e96c65414e809ab1f
http://europepmc.org/articles/PMC2806042
http://europepmc.org/articles/PMC2806042
Autor:
Amritpal Mudher, T. Burbidge-King, J.L. Marsh, Leslie M. Thompson, Andreas Wyttenbach, D. Soh, Christopher Sinadinos
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 2, Pp 389-395 (2009)
Sinadinos, C; Burbidge-King, T; Soh, D; Thompson, LM; Marsh, JL; Wyttenbach, A; et al.(2009). Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons. Neurobiology of Disease, 34(2), 389-395. doi: 10.1016/j.nbd.2009.02.012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/30g9v0dv
Sinadinos, C; Burbidge-King, T; Soh, D; Thompson, LM; Marsh, JL; Wyttenbach, A; et al.(2009). Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons. Neurobiology of Disease, 34(2), 389-395. doi: 10.1016/j.nbd.2009.02.012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/30g9v0dv
Huntington's Disease is a neurodegenerative condition caused by a polyglutamine expansion in the huntingtin (Htt) protein, which aggregates and also causes neuronal dysfunction. Pathogenic N-terminal htt fragments perturb axonal transport in vitro. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae09498de4caf9d5ee07db92c77ba70
http://www.sciencedirect.com/science/article/pii/S0969996109000424
http://www.sciencedirect.com/science/article/pii/S0969996109000424
Autor:
Matthew A. King, Aviva M. Tolkovsky, Jochen H. M. Prehn, Farida Hafiz, Christoph G. Goemans, Andreas Wyttenbach
Publikováno v:
The Journal of Neuroscience. 28:14401-14415
Proteins containing extended polyglutamine repeats cause at least nine neurodegenerative disorders, but the mechanisms of disease-related neuronal death remain uncertain. We show that sympathetic neurons containing cytoplasmic inclusions formed by 97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1432357c4cf55fd83cacba8c45ab79
https://doi.org/10.1523/jneurosci.4751-08.2008
https://doi.org/10.1523/jneurosci.4751-08.2008
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1779:507-521
The coordinated regulation of gene expression and protein interactions determines how mammalian nervous systems develop and retain function and plasticity over extended periods of time such as a human life span. By studying mutations that occur in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81efdaa1c69013c883add4694fcbab2d
https://doi.org/10.1016/j.bbagrm.2008.05.008
https://doi.org/10.1016/j.bbagrm.2008.05.008
Publikováno v:
Autophagy. 4:542-545
Rapamycin is an inhibitor of mTOR, a key component of the mTORC1 complex that controls the growth and survival of cells in response to growth factors, nutrients, energy balance and stresses. The downstream targets of mTORC1 include ribosome biogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d9dc100f91368f6a3ff94155ee629d
https://doi.org/10.4161/auto.6059
https://doi.org/10.4161/auto.6059
Autor:
Vincent O'Connor, Victor Hugh Perry, Robert Fern, Andreas Wyttenbach, Nyasha Matinyarare, Shmma Quraishe
Publikováno v:
Neuroscience. 316
In the present study, we reveal myelin specific expression and targeting of mRNA and biochemical pools of HspB5 in the mouse CNS. Our observations are based on in-situ hybridisation, electron microscopy and co-localisation with 2’,3’-Cyclin-Nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c37ad6ab4759904d74f035bca5239f
https://pubmed.ncbi.nlm.nih.gov/26718604
https://pubmed.ncbi.nlm.nih.gov/26718604