Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Andreas Wiederkehr"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 273-288 (2024)
Abstract Autophagy is an essential quality control mechanism for maintaining organellar functions in eukaryotic cells. Defective autophagy in pancreatic beta cells has been shown to be involved in the progression of diabetes through impaired insulin
Externí odkaz:
https://doaj.org/article/56433016b68740f19f72782865e25210
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 6, Pp 1474-1474 (2024)
Externí odkaz:
https://doaj.org/article/ff7eb29647d849628333a81c93aec9bd
Autor:
Corinne Haller, Julie Piccand, Filippo De Franceschi, Yuki Ohi, Anindita Bhoumik, Christophe Boss, Umberto De Marchi, Guillaume Jacot, Sylviane Metairon, Patrick Descombes, Andreas Wiederkehr, Alessio Palini, Nicolas Bouche, Pascal Steiner, Olivia G. Kelly, Marine R.-C. Kraus
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 787-800 (2019)
Summary: In type 1 diabetes, a renewable source of human pancreatic β cells, in particular from human induced pluripotent stem cell (hiPSC) origin, would greatly benefit cell therapy. Earlier work showed that pancreatic progenitors differentiated fr
Externí odkaz:
https://doaj.org/article/3f66809f796c41b7b0c7c165f61695af
Autor:
Jaime Santo-Domingo, Antonio Núñez Galindo, Ornella Cominetti, Umberto De Marchi, Pedro Cutillas, Loïc Dayon, Andreas Wiederkehr
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-19 (2019)
Abstract Background Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is associated with a pronou
Externí odkaz:
https://doaj.org/article/630414b375bd4c67a6b87d4f1b051dc9
Autor:
Julien Marquis, Gregory Lefebvre, Yiannis A. I. Kourmpetis, Mohamed Kassam, Frédéric Ronga, Umberto De Marchi, Andreas Wiederkehr, Patrick Descombes
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-19 (2017)
Abstract Background Mitochondrial dysfunction is linked to numerous pathological states, in particular related to metabolism, brain health and ageing. Nuclear encoded gene polymorphisms implicated in mitochondrial functions can be analyzed in the con
Externí odkaz:
https://doaj.org/article/adfb5723054345a9a8bebe8591d45b4b
Autor:
Sarah Sonnay, Anirikh Chakrabarti, Jonathan Thevenet, Andreas Wiederkehr, Nicolas Christinat, Mojgan Masoodi
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Medium-chain triglyceride (MCT) ketogenic diets increase ketone bodies, which are believed to act as alternative energy substrates in the injured brain. Octanoic (C8:0) and decanoic (C10:0) acids, which produce ketone bodies through β-oxidation, are
Externí odkaz:
https://doaj.org/article/f52396f790b549fd9c589715223ec586
Autor:
Sarah Sonnay, Nicolas Christinat, Jonathan Thevenet, Andreas Wiederkehr, Anirikh Chakrabarti, Mojgan Masoodi
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 487 (2020)
The utilization of alternative energy substrates to glucose could be beneficial in traumatic brain injury (TBI). Recent clinical data obtained in TBI patients reported valine, β-hydroxyisobutyrate (ibHB) and 2-ketoisovaleric acid (2-KIV) as three of
Externí odkaz:
https://doaj.org/article/5ca5e521d23e48bf86c3a4643bb5ca6a
Autor:
Jaime Santo-Domingo, Steve Lassueur, Antonio Núñez Galindo, Pilar Alvarez-Illera, Silvia Romero-Sanz, Elena Caldero-Escudero, Sergio de la Fuente, Loïc Dayon, Andreas Wiederkehr
Publikováno v:
Journal of Cell Science. 136
Glucose sensing in pancreatic β-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteomics to search for downstream effectors of glucose-dependent signa
Autor:
Aurélien Trompette, Julie Pernot, Olaf Perdijk, Rayed Ali A. Alqahtani, Jaime Santo Domingo, Dolores Camacho-Muñoz, Nicholas C. Wong, Alexandra C. Kendall, Andreas Wiederkehr, Laurent P. Nicod, Anna Nicolaou, Christophe von Garnier, Niki D.J. Ubags, Benjamin J. Marsland
Publikováno v:
Mucosal immunology, vol. 15, no. 5, pp. 908-926
Trompette, A, Pernot, J, Perdijk, O, Alqahtani, R A A, Domingo, J S, Camacho-Munoz, D, Wong, N C, Kendall, A C, Wiederkehr, A, Nicod, L P, Nicolaou, A, von Garnier, C, Ubags, N D J & Marsland, B J 2022, ' Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation ', Mucosal Immunology . https://doi.org/10.1038/s41385-022-00524-9
Trompette, A, Pernot, J, Perdijk, O, Alqahtani, R A A, Domingo, J S, Camacho-Munoz, D, Wong, N C, Kendall, A C, Wiederkehr, A, Nicod, L P, Nicolaou, A, von Garnier, C, Ubags, N D J & Marsland, B J 2022, ' Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation ', Mucosal Immunology . https://doi.org/10.1038/s41385-022-00524-9
Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7907f1ef43b16410e1893f1591996c
https://serval.unil.ch/resource/serval:BIB_A24A5D715550.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_A24A5D715550.P001/REF.pdf
Autor:
Andreas Wiederkehr, Jaime Santo-Domingo, Silvia Fernandez-Martinez, Sergio de la Fuente, Umberto De Marchi
Publikováno v:
British Journal of Pharmacology
Pancreatic beta-cells are central regulators of glucose homeostasis. By tightly coupling nutrient sensing and granule exocytosis, beta-cells adjust the secretion of insulin to the circulating blood glucose levels. Failure of beta-cells to augment ins