Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Andreas Wernitznig"'
1
Akademický článek
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
Autor: Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A Neumüller, Jan-Michael Peters, Norbert Kraut, Mark A Pearson, Mark Petronczki, Simon Wöhrle
Publikováno v: eLife, Vol 8 (2019)
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite i
Externí odkaz: https://doaj.org/article/bcf5373f995c49dd883a2b357adfa700
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2
Akademický článek
A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.
Autor: Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Xia Cuiping, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane J F Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger
Publikováno v: PLoS Genetics, Vol 14, Iss 10, p e1007688 (2018)
Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in v
Externí odkaz: https://doaj.org/article/398b05ace50540ebbc5d12234222f441
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3
Akademický článek
High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.
Autor: Albin Rudisch, Matthew Richard Dewhurst, Luminita Gabriela Horga, Nina Kramer, Nathalie Harrer, Meng Dong, Heiko van der Kuip, Andreas Wernitznig, Andreas Bernthaler, Helmut Dolznig, Wolfgang Sommergruber
Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124283 (2015)
We established co-cultures of invasive or non-invasive NSCLC cell lines and various types of fibroblasts (FBs) to more precisely characterize the molecular mechanism of tumor-stroma crosstalk in lung cancer. The HGF-MET-ERK1/2-CREB-axis was shown to
Externí odkaz: https://doaj.org/article/1cd708db78024fd595c13cbe9731f2c4
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9
Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells
Autor: Nathalie Harrer, Annika Osswald, Andreas Wernitznig, Ingrid Christ, Albin Rudisch, Aleksander Rust, David J. Lamb, Herwig Machat, Wolfgang Sommergruber, Florian Colbatzky, Tobias Glüxam
Publikováno v: Oncotarget
SYK has been reported to possess both tumour promotor and repressor activities and deletion has been linked to a pro-proliferative / pro-invasive phenotype in breast tumours. It is unclear whether this is a consequence of protein deletion or loss of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704a402869c39282cf28e4bf450002a0
https://doi.org/10.18632/oncotarget.27545
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