Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Andreas Weith"'
Autor:
Patrick Baum, Ramona Schmid, Carina Ittrich, Werner Rust, Katrin Fundel-Clemens, Susanne Siewert, Martin Baur, Lisa Mara, Lore Gruenbaum, Armin Heckel, Roland Eils, Roland E Kontermann, Gerald J Roth, Florian Gantner, Andreas Schnapp, John E Park, Andreas Weith, Karsten Quast, Detlev Mennerich
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14272 (2010)
A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual. The phenocopy phenomenon has been translated to the drug discovery process as phenotypes p
Externí odkaz:
https://doaj.org/article/7e2fb73d5ce749f599c79099e9a76b50
Autor:
Heiko F Stahl, Tanja Fauti, Nina Ullrich, Tobias Bopp, Jan Kubach, Werner Rust, Paul Labhart, Vassili Alexiadis, Christian Becker, Mathias Hafner, Andreas Weith, Martin C Lenter, Helmut Jonuleit, Edgar Schmitt, Detlev Mennerich
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7158 (2009)
BackgroundIn humans and mice naturally occurring CD4(+)CD25(+) regulatory T cells (nTregs) are a thymus-derived subset of T cells, crucial for the maintenance of peripheral tolerance by controlling not only potentially autoreactive T cells but virtua
Externí odkaz:
https://doaj.org/article/e9945b4d46fd4efaa142babce0014603
Autor:
Eric Simon, Detlev Mennerich, Tanja Fauti, Fabian Birzele, Martin Lenter, Tobias Hildebrandt, Dagmar Knebel, Heiko Stahl, Andreas Weith
Publikováno v:
Nucleic Acids Research
Regulatory T-cells (Treg) play an essential role in the negative regulation of immune answers by developing an attenuated cytokine response that allows suppressing proliferation and effector function of T-cells (CD4(+) Th). The transcription factor F
Autor:
Torsten W. Schulz, Jochen Schaub, Patrick Baum, Christoph Clemens, Werner Rust, Andreas Weith, Hitto Kaufmann, Tobias Hildebrandt, Fabian Birzele
Publikováno v:
Nucleic Acids Research
The arrival of next-generation sequencing (NGS) technologies has led to novel opportunities for expression profiling and genome analysis by utilizing vast amounts of short read sequence data. Here, we demonstrate that expression profiling in organism
Autor:
Andreas Weith, Roland E. Kontermann, Sebastian Kreuz, Katrin Fundel-Clemens, Patrick Baum, Detlev Mennerich, Jörg F. Rippmann
Publikováno v:
Oligonucleotides. 20:17-26
The use of RNA interference for the manipulation of gene expression has seen great applications from basic science to clinical investigations. However, limited selectivity and the induction of off-target effects by double stranded RNA molecules have
Autor:
Ido H Tamir, Hartmut Beug, Susanna Lüdemann, Peter Seither, Martin Jechlinger, Elzbieta Janda, Thomas Waerner, Norbert Kraut, Stefan Grünert, Andreas Weith
Publikováno v:
Oncogene. 22:7155-7169
Epithelial-to-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is increasingly considered as an important event during malignant tumor progression and metastasis. To identify molecular play
Autor:
Andreas Weith, Anita Kobrna, Wilfried Ellmeier, Christoph M. Barnas, Elke Kleiner, Robert Kurzbauer
Publikováno v:
Genomics. 32:155-158
CpG islands were identified and localized to chromosome 1p36 by means of pulsed-field gel blot hybridization with 1p36-specific microclone probes. Five CpG islands, designated CpG17, CpG28, CpG60, CpG112a, and CpG112b, were molecularly cloned from co
Autor:
Christoph M. Barnas, Christoph Brunner, Elke Kleiner, Christoph Lengauer, Wilfried Ellmeier, Paula Stapleton, Traudl Henn, Andreas Weith, Patrick Onyango
Publikováno v:
Genomics. 29:607-615
In an approach to mapping physically the most distal 30 Mb of human chromosome 1p, region-specific clone libraries were generated by microdissection and microcloning. PFGE blot hybridization of single or low-copy microclones against rare-cutter diges
Autor:
Kathryn L. Evans, John Brown, Yoshiro Shibasaki, Rebecca S. Devon, Lin He, Benoit Arveiler, Sheila Christie, John C. Maule, David Baillie, Euan M. Slorach, Susan M. Anderson, John R. Gosden, Joelle Petit, Andreas Weith, Christine M. Gosden, Douglas H.R. Blackwood, David M. St. Clair, Walter J. Muir, Anthony J. Brookes, David J. Porteous
Publikováno v:
Genomics. 28:420-428
Forty-nine clones derived by microdissection of a schizophrenia-associated t(1;11)(q42.1;q14.3) breakpoint region have been assigned by somatic cell hybrid mapping to seven discrete intervals on the long arm of human chromosome 11. Eleven of the clon
Autor:
Andreas Weith, Denise P. Barlow, Ingrid Fae, Traudi Henn, Reinhard Stöger, Robert Kurzbauer, Gottfried Fischer, Oskar W. Smrzka
Publikováno v:
Human Molecular Genetics. 4:1945-1952
The human IGF2R gene has been reported to be either biallelically or very rarely monoallelically expressed, in contrast to the maternally expressed mouse counterpart. We describe here an analysis of the 5' portion of the human IGF2R gene and show tha