Improving diagnostic accuracy of the Montreal Cognitive Assessment to identify post-stroke cognitive impairment

Autor: Laura Gallucci, Christoph Sperber, Andreas U. Monsch, Stefan Klöppel, Marcel Arnold, Roza M. Umarova

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Given advantages in reperfusion therapy leading to mild stroke, less apparent cognitive deficits can be overseen in a routine neurological examination. Despite the widespread use of the Montreal Cognitive Assessment (MoCA), age- and educatio

Externí odkaz: https://doaj.org/article/8726ff29b4ba44368796f2cd0cb99072

Blood‐based biomarkers in Alzheimer's disease: Future directions for implementation

Autor: Ivonne Suridjan, Wiesje M. van derFlier, Andreas U. Monsch, Nerida Burnie, Robert Baldor, Marwan Sabbagh, Josep Vilaseca, Dongming Cai, Margherita Carboni, James J. Lah

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)

Abstract INTRODUCTION Disease‐modifying therapies (DMTs) for Alzheimer's disease (AD) will increase diagnostic demand. A non‐invasive blood‐based biomarker (BBBM) test for detection of amyloid‐β pathology may reduce diagnostic barriers and f

Externí odkaz: https://doaj.org/article/a83a038067c846c68d79fcbef566b41b

Sex differences of vascular brain lesions in patients with atrial fibrillation

Autor: Christian Müller, Leo H Bonati, Pascal Meyre, Steffen Blum, Stefanie Aeschbacher, David Conen, Stefan Osswald, Urs Fischer, Manuel R Blum, Simon Jung, Jens Wuerfel, Christian Sticherling, Michael Kuhne, Philipp Krisai, Matthias Schwenkglenks, Luise Adam, Elisavet Moutzouri, Martin Feller, Nathalie Schwab, Claudio Schneider, Drahomir Aujesky, Nicolas Rodondi, Karl-Olof Lovblad, Michael Amann, Richard Kobza, Marie Méan, Andreas Müller, Giorgio Moschovitis, Fabienne Witassek, Silke Küest, Sonja Meier, Jürg-Hans Beer, Damiana Rakovic, Michael Coslovsky, Tiziano Moccetti, Ramun Schmid, Augusto Gallino, Carole Elodie Aubert, Georg Ehret, Angelo Auricchio, Giulio Conte, Daniel Hayoz, Benjamin Berte, Nathalie Lauriers, Peter Ammann, François Regoli, Dipen Shah, Laurent Roten, Marco Düring, Pascal Benkert, Simone Evers-Dörpfeld, Elisa Hennings, Ceylan Eken, Selinda Ceylan, Anne Springer, Heinrich Mattle, Tim Sinnecker, Leo Bonati, Anna Altermatt, Manuel Blum, Sacha Niederberger, Chloé Auberson, Simone Evers-Doerpfeld, Marc Girod, Elena Herber, Vasco Iten, Mirko Lischer, Christine Meyer-Zürn, Andreas U Monsch, Thomas Szucs, Gian Völlmin, Juerg Fuhrer, Axel Loewe, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Simone Fontana, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Adriana Anesini, Cristina Camporini, Maria Luce Caputo, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Luisa Vicari, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Patrick Perret, Philippe Tavel, Cheryl Teres, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Jane Frangi-Kultalahti, Marcello Di Valentino, Jens Würfel, Petra Huber, Esther Ruberte, Vanessa Zuber, Gilles Dutilh, Milica Markovic, Pia Neuschwander, Patrick Simon

Publikováno v: Open Heart, Vol 9, Iss 2 (2022)

Objective To examine sex differences in prevalence, volume and distribution of vascular brain lesions on MRI among patients with atrial fibrillation (AF).Methods In this cross-sectional analysis, we included 1743 patients with AF (27% women) from the

Externí odkaz: https://doaj.org/article/b73f1541a93e40d498515f2bba783d7b

Enhanced diagnostic accuracy for neurocognitive disorders: a revised cut-off approach for the Montreal Cognitive Assessment

Autor: Alessandra E. Thomann, Manfred Berres, Nicolai Goettel, Luzius A. Steiner, Andreas U. Monsch

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)

Abstract Background The Montreal Cognitive Assessment (MoCA) has good sensitivity for mild cognitive impairment, but specificity is low when the original cut-off (25/26) is used. We aim to revise the cut-off on the German MoCA for its use in clinical

Externí odkaz: https://doaj.org/article/1a0af852e93441aaad1a5d1a0302e07f

Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice

Autor: Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U. Monsch, Michel Goedert, Markus Tolnay, David T. Winkler

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-9 (2019)

Abstract Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer’s disease (AD). Tau derived from AD patients’ brains induces tau aggregation in a prion-like manner when injected into susceptible mouse models. Here we investig

Externí odkaz: https://doaj.org/article/82fce56f28d34a8fb864ea0b8277378e