Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Andreas T Schaefer"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009808 (2022)
Sensory processing is hard because the variables of interest are encoded in spike trains in a relatively complex way. A major goal in studies of sensory processing is to understand how the brain extracts those variables. Here we revisit a common enco
Externí odkaz:
https://doaj.org/article/673a2675b01944a0bbd8e32c6822f353
Autor:
Sara Zeppilli, Tobias Ackels, Robin Attey, Nell Klimpert, Kimberly D Ritola, Stefan Boeing, Anton Crombach, Andreas T Schaefer, Alexander Fleischmann
Publikováno v:
eLife, Vol 10 (2021)
Projection neurons (PNs) in the mammalian olfactory bulb (OB) receive input from the nose and project to diverse cortical and subcortical areas. Morphological and physiological studies have highlighted functional heterogeneity, yet no molecular marke
Externí odkaz:
https://doaj.org/article/9685d58b0eb44b04902fd781b4e922aa
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0211571 (2019)
Operant conditioning is a crucial tool in neuroscience research for probing brain function. While molecular, anatomical and even physiological techniques have seen radical increases in throughput, efficiency, and reproducibility in recent years, beha
Externí odkaz:
https://doaj.org/article/132f52c2e824450cba175ba9abe8a026
Autor:
Benjamin Roland, Rebecca Jordan, Dara L Sosulski, Assunta Diodato, Izumi Fukunaga, Ian Wickersham, Kevin M Franks, Andreas T Schaefer, Alexander Fleischmann
Publikováno v:
eLife, Vol 5 (2016)
Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a “monoclonal nose”, glomerular input patterns in the olfactory bulb are massively perturbed and olfactory be
Externí odkaz:
https://doaj.org/article/17be6909b1e04e3c94d6140f307a8624
Autor:
Matthew R Angle, Andreas T Schaefer
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43194 (2012)
Direct electrical recording of the neuronal transmembrane potential has been crucial to our understanding of the biophysical mechanisms subserving neuronal computation. Existing intracellular recording techniques, however, limit the accuracy and dura
Externí odkaz:
https://doaj.org/article/8dc471d8bf8647f9813fd8728e8c37e7
Publikováno v:
PLoS Biology, Vol 4, Iss 6, p e163 (2006)
Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive. Here we show, using a combination of in vivo, in vitro, and theoretical approaches
Externí odkaz:
https://doaj.org/article/98a36ecee7294190a1bcd2535b9f8da9
Autor:
Derya R Shimshek, Thorsten Bus, Jinhyun Kim, Andre Mihaljevic, Volker Mack, Peter H Seeburg, Rolf Sprengel, Andreas T Schaefer
Publikováno v:
PLoS Biology, Vol 3, Iss 11, p e354 (2005)
Genetic perturbations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study, we investigated the role of Ca2+-permeable AMPARs
Externí odkaz:
https://doaj.org/article/8d38161d707544e7a975a190a6c8cc4a
Autor:
Mihaly Kollo, Romeo Racz, Mina-Elraheb Hanna, Abdulmalik Obaid, Matthew R. Angle, William Wray, Yifan Kong, Jan Müller, Andreas Hierlemann, Nicholas A. Melosh, Andreas T. Schaefer
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Mammalian brains consist of 10s of millions to 100s of billions of neurons operating at millisecond time scales, of which current recording techniques only capture a tiny fraction. Recording techniques capable of sampling neural activity at high spat
Externí odkaz:
https://doaj.org/article/83c575a2ca9d445ea718b93939387d3f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
For sensory systems of the brain, the dynamics of an animal’s own sampling behavior has a direct consequence on ensuing computations. This is particularly the case for mammalian olfaction, where a rhythmic flow of air over the nasal epithelium entr
Externí odkaz:
https://doaj.org/article/4658a0b9cb294e4b980ddd58b11bd71c
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Behavioral phenotyping of mice is often compromised by manual interventions of the experimenter and limited throughput. Here, we describe a fully automated behavior setup that allows for quantitative analysis of mouse olfaction with minimized experim
Externí odkaz:
https://doaj.org/article/f589cd01d0244a71811dd78dd81ffafb