Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

Autor: Janus RL Kobbersmed, Andreas T Grasskamp, Meida Jusyte, Mathias A Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter

Publikováno v: eLife, Vol 9 (2020)

Chemical synaptic transmission relies on the Ca2+-induced fusion of transmitter-laden vesicles whose coupling distance to Ca2+ channels determines synaptic release probability and short-term plasticity, the facilitation or depression of repetitive re

Externí odkaz: https://doaj.org/article/841c0dc459564a0092ae687a9074b6fc

OWSum: algorithmic odor prediction and insight into structure-odor relationships

Autor: Doris Schicker, Satnam Singh, Jessica Freiherr, Andreas T. Grasskamp

Publikováno v: Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-11 (2023)

Abstract We derived and implemented a linear classification algorithm for the prediction of a molecule’s odor, called Olfactory Weighted Sum (OWSum). Our approach relies solely on structural patterns of the molecules as features for algorithmic tre

Externí odkaz: https://doaj.org/article/24633b94b2e3490c8962eadeb805dcc5

Rapid active zone remodeling consolidates presynaptic potentiation

Autor: Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter r

Externí odkaz: https://doaj.org/article/9733b2fe50774e4e995b69653b092187

Assisting the automated analysis of chemical-analytical measurements in spirits using validated algorithms and an intuitive user interface

Autor: Andreas T. Grasskamp, Satnam Singh, Helen Haug, Tilman Sauerwald

Exhaustive analysis of chemical measurements requires considerable expenditure of time and personnel. However, many aspects of this can be automated by translating manual work into objective algorithmic routines. To this end, we developed adaptable s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef69465e75762af54c554cdf99d166eb
https://publica.fraunhofer.de/handle/publica/441439

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials

Autor: Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W.B. Götz, Susanne Ditlevsen, Alexander M. Walter

Publikováno v: Grasskamp, A T, Jusyte, M, McCarthy, A W, Götz, T W B, Ditlevsen, S & Walter, A M 2023, ' Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials ', Frontiers in Cellular Neuroscience, vol. 17, 1129417 . https://doi.org/10.3389/fncel.2023.1129417

Synaptic transmission relies on presynaptic neurotransmitter (NT) release from synaptic vesicles (SVs) and on NT detection by postsynaptic receptors. Transmission exists in two principal modes: action-potential (AP) evoked and AP-independent, “spon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1054f2c84fda9009a439f363c9765011
https://doi.org/10.1101/2020.08.28.271742