Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Andreas Skyschally"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionDiazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration. Diazoxide reduced infarct size in isolated rodent heart preparations and upon pretreatment in j
Externí odkaz:
https://doaj.org/article/b2d4538d47d74f1099b721abc96e8c86
Publikováno v:
Physiological Reports, Vol 7, Iss 19, Pp n/a-n/a (2019)
Abstract The ischemic area at risk (AAR) is one major determinant of infarct size (IS). In patients, the largest AAR is seen with a proximal occlusion of the left anterior descending (LAD) coronary artery, which serves parts of the septum and of the
Externí odkaz:
https://doaj.org/article/8580a80a71ca47ecb5c7965139432d5e
Autor:
Nilgün Gedik, Marcus Krüger, Matthias Thielmann, Eva Kottenberg, Andreas Skyschally, Ulrich H. Frey, Elke Cario, Jürgen Peters, Heinz Jakob, Gerd Heusch, Petra Kleinbongard
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-22 (2017)
Abstract Remote ischemic preconditioning (RIPC) by repeated brief cycles of limb ischemia/reperfusion reduces myocardial ischemia/reperfusion injury. In left ventricular (LV) biopsies from patients undergoing coronary artery bypass grafting (CABG), o
Externí odkaz:
https://doaj.org/article/aa6a00b31d2640908e8cdccec0bfb8a4
Cardiomyocyte mitochondria as targets of humoral factors released by remote ischemic preconditioning
Autor:
Nilguen Gedik, Leonardo Maciel, Christiane Schulte, Andreas Skyschally, Gerd Heusch, Petra Kleinbongard
Publikováno v:
Archives of Medical Science, Vol 13, Iss 2, Pp 448-458 (2016)
Introduction: Remote ischemic preconditioning (RIPC) reduces myocardial infarct size, and protection can be transferred with plasma to other individuals, even across species. Mitochondria are the end-effectors of cardioprotection by local ischemic co
Externí odkaz:
https://doaj.org/article/71b7d9514ddd4ed1940e1926b2ae42ad
Autor:
Philipp Heusch, Andreas Skyschally, Kirsten Leineweber, Michael Haude, Raimund Erbel, Gerd Heusch
Publikováno v:
Archives of Medical Science, Vol 3, Iss 2, Pp 83-92 (2007)
With an unstable atherosclerotic coronary plaque, episodes of myocardial ischemia associated with release of debris and microembolization and subsequent restoration of more or less sufficient coronary blood flow can precede ultimate plaque rupture, c
Externí odkaz:
https://doaj.org/article/2237011ad48e48d1a92c5fee074bca3e
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1365-H1375
Ischemic preconditioning (IPC; brief cycles of coronary occlusion/reperfusion) is operative in all species tested so far and reduces infarct size through the release of trigger molecules and activation of signal transducer and activator of transcript
Publikováno v:
Physiology. 38
Background: Vagal activation during remote ischemic conditioning (RIC) with subsequent release of cardioprotective factors from the spleen into the circulation reduces infarct size. These humoral cardioprotective factors can be transferred with plasm
Publikováno v:
Cardiovascular Research. 119:561-570
Aims Female sex has been proposed to be cardioprotective per se. Studies with myocardial ischaemia/reperfusion and infarct size as endpoint have demonstrated cardioprotection in female, castrated male, and male pigs. These studies are difficult to co
Autor:
Petra Kleinbongard, Helmut Raphael Lieder, Andreas Skyschally, Mouhamad Alloosh, Axel Gödecke, Sven Rahmann, Michael Sturek, Gerd Heusch
Publikováno v:
Basic research in cardiology. 117(1)
The translation of successful preclinical and clinical proof-of-concept studies on cardioprotection to the benefit of patients with reperfused acute myocardial infarction has been difficult so far. This difficulty has been attributed to confounders w
Publikováno v:
International Journal of Cardiology. 258:17-23
Plaque erosion, fissuring or rupture occurs spontaneously or during coronary interventions. At some residual blood flow, the atherothrombotic debris is washed into the coronary microcirculation, causing physical obstruction, vasoconstriction, inflamm