Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andreas Sebastian Klein"'
Publikováno v:
Catalysts, Vol 11, Iss 11, p 1389 (2021)
1,2,3,4-Tetrahydroisoquinolines form a valuable scaffold for a variety of bioactive secondary metabolites and commercial pharmaceuticals. Due to the harsh or complex conditions of the conventional chemical synthesis of this molecular motif, alternati
Externí odkaz:
https://doaj.org/article/a1066c6a63b84c6aab67d10621853eaa
Autor:
Jennifer Hage-Hülsmann, Alexander Grünberger, Stephan Thies, Beatrix Santiago-Schübel, Andreas Sebastian Klein, Jörg Pietruszka, Dennis Binder, Fabienne Hilgers, Andreas Domröse, Thomas Drepper, Dietrich Kohlheyer, Karl-Erich Jaeger, Anita Loeschcke
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200940 (2018)
Bacterial secondary metabolites are naturally produced to prevail amongst competitors in a shared habitat and thus represent a valuable source for antibiotic discovery. The transformation of newly discovered antibiotic compounds into effective drugs
Externí odkaz:
https://doaj.org/article/bcd137b3eb2945cdadbc59a6436e5251
Autor:
Andreas eDomröse, Andreas Sebastian Klein, Jennifer eHage-Hülsmann, Stephan eThies, Vera eSvensson, Thomas eClassen, Jörg ePietruszka, Karl-Erich eJaeger, Thomas eDrepper, Anita eLoeschcke
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Serratia marcescens and several other bacteria produce the red-colored pigment prodigiosin which possesses bioactivities as an antimicrobial, anticancer and immunosuppressive agent. Therefore, there is a great interest to produce this natural compoun
Externí odkaz:
https://doaj.org/article/b8a4278acc124410948a5b3475ba81de
Autor:
Anna Joëlle Ruff, Ulrich Schwaneberg, Mehdi D. Davari, Jarno G. Sikkens, Hannah U. C. Brass, Stefanie Brands, Andreas Sebastian Klein, Jörg Pietruszka
Publikováno v:
Catalysis Science & Technology. 11:2805-2815
Prodigiosin ligase PigC catalyses the final condensation step in the prodigiosin biosynthesis of Serratia marcescens, in which two pyrrolic precursor molecules are fused linearly to form tripyrrolic red prodiginines. Prodiginine compounds attracted i
Autor:
Stefanie Brands, Andreas Sebastian Klein, Anna Joëlle Ruff, Hannah U. C. Brass, Jörg Pietruszka, Ulrich Schwaneberg
Publikováno v:
Chemical communications 56(61), 8631-8634 (2020). doi:10.1039/D0CC02181D
A colourimetric high-throughput screening system was established for directed evolution of prodigiosin ligase PigC. The two-step system consists of a colony prescreening test and a subsequent photometric 96-well plate assay. Screening PigC epPCR libr
Publikováno v:
Catalysts 11(11), 1389-(2021). doi:10.3390/catal11111389
Catalysts
Volume 11
Issue 11
Catalysts, Vol 11, Iss 1389, p 1389 (2021)
Catalysts
Volume 11
Issue 11
Catalysts, Vol 11, Iss 1389, p 1389 (2021)
1,2,3,4-Tetrahydroisoquinolines form a valuable scaffold for a variety of bioactive secondary metabolites and commercial pharmaceuticals. Due to the harsh or complex conditions of the conventional chemical synthesis of this molecular motif, alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e8c31c9df6f705c4b733a7c327d8a6
https://hdl.handle.net/2128/29781
https://hdl.handle.net/2128/29781
Autor:
Stefanie Brands, Anna Joëlle Ruff, Ulrich Schwaneberg, Hannah U. C. Brass, Jarno G. Sikkens, Andreas Sebastian Klein, Mehdi D. Davari, Jörg Pietruszka
Publikováno v:
Chemical communications 57(21), 2681-2684 (2021). doi:10.1039/D0CC08226K
Semi-rational redesign of the substrate binding pocket and access tunnels of prodigiosin ligase PigC enhanced the catalytic efficiency in the synthesis of pyrrolic anti-cancer agents more than 45 times. A molecular understanding was gained on residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b952fe0f46c3c05393c8c145573311dc
https://hdl.handle.net/2128/29752
https://hdl.handle.net/2128/29752
Publikováno v:
Protein engineering, designselection : PEDS. 34
Metalloproteins are essential to sustain life. Natural evolution optimized them for intricate structural, regulatory and catalytic functions that cannot be fulfilled by either a protein or a metal ion alone. In order to understand this synergy and th
Autor:
Jörg Pietruszka, Thomas Classen, David Paul Klebl, Hannah U. C. Brass, Florian M. W. Grundler, Andreas Sebastian Klein, A. Sylvia S. Schleker, Samer S. Habash, Tim Moritz Weber
Publikováno v:
Frontiers in Functional Plant Ecology 11, 579807 (2020). doi:10.3389/fpls.2020.579807
Frontiers in Plant Science, Vol 11 (2020)
Frontiers in Plant Science
Frontiers in Plant Science, Vol 11 (2020)
Frontiers in Plant Science
Bacterial metabolites represent an invaluable source of bioactive molecules which can be used as such or serve as chemical frameworks for developing new antimicrobial compounds for various applications including crop protection against pathogens. Pro
Autor:
Luca Laraia, Anita Loeschcke, Karl-Erich Jaeger, Sonja Sievers, Hannah U. C. Brass, Andreas Sebastian Klein, Andreas Domröse, Joerg Pietruszka, Thomas Classen, Patrick Bongen, Thomas Drepper
Publikováno v:
ACS Synthetic Biology. 6:1757-1765
The deeply red-colored natural compound prodigiosin is a representative of the prodiginine alkaloid family, which possesses bioactivities as antimicrobial, antitumor, and antimalarial agents. Various bacteria including the opportunistic human pathoge