MET Amplification Status in Therapy-Naïve Adeno- and Squamous Cell Carcinomas of the Lung

Autor: Jana Fassunke, Josef Rüschoff, Andreas Schlesinger, Elke Binot, Hans-Ulrich Schildhaus, Yon-Dschun Ko, Konrad Frank, Masyar Gardizi, Marc Bos, Walburga Engel-Riedel, Erich Stoelben, Anne M Schultheis, Reinhard Buettner, Monika Serke, M. Reiser, Michael Brockmann, Stefan Krüger, Jürgen Wolf, Khosro Hekmat, Sabine Merkelbach-Bruse, Wolfgang Schulte, Thomas Zander, UIlrich Gerigk, Holger Schulz

Publikováno v: Clinical Cancer Research. 21:907-915

Purpose: MET is a potential therapeutic target in lung cancer and both MET tyrosine kinase inhibitors and monoclonal antibodies have entered clinical trials. MET signaling can be activated by various mechanisms, including gene amplification. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4323e9f40313b22c95837a2aaa24a4d3
https://doi.org/10.1158/1078-0432.ccr-14-0450

A Genomics-Based Classification of Human Lung Tumors

Autor: Sabine Merkelbach-Bruse, Odd Terje Brustugun, Marius Lund-Iversen, Philipp A. Schnabel, Hans Hoffmann, Katharina Koenig, Kato Kambartel, Matthias Scheffler, Reinhard Buettner, Harry J.M. Groen, Jana Fassunke, C. Ligorio, Helen Kuenstlinger, Peter Nuemberg, Sylvie Lantuejoul, William Pao, Philippe Girard, Khosro Hekmat, Johannes Berg, Franziska Gabler, Winfried Randerath, Åslaug Helland, Joerg Saenger, Andreas Schlesinger, Elisabeth Brambilla, Lucia Nogova, Vito Michele Fazio, Monika Serke, Lucia Anna Muscarella, Ines Wilkening, Walburga Engel-Riedel, Sven Perner, Ilona Dahmen, Erich Stoelben, Steinar Solberg, Benjamin Solomon, Hans-Ulrich Schildhaus, Stefan Krueger, Lisa Meffert, Peter M. Schneider, Stefania Damiani, Elke Binot, Katja Schmitz, Toni-Maree Rogers, Ali-Nuri Huenerlituerkoglu, Ulrich Lang, Janine Altmueller, Hannie Sietsma, Chau Nguyen, Lynnette Fernandez-Cuesta, Pierre Validire, Federico Cappuzzo, Christian Mueller, Ulrich Gerigk, Gad Getz, Dirk Behringer, Christian Mattonet, Xin Lu, Wim Timens, Roman K. Thomas, Philippe Lorimier, Masyar Gardizi, Yuan Chen, William D. Travis, Thomas Zander, Prudence A. Russell, Danila Seidel, Marc Bos, Michaela Angelika Kleine, Egbert F. Smit, Matthias Heldwein, Corinna Ludwig, Russell Hyde, Scott L. Carter, Peter J.F. Snijders, Kerstin Albus, Roland Schnell, Alex Soltermann, Michael Hallek, Wolfgang Galetke, Eray Goekkurt, Benjamin Besse, Frauke Leenders, John K. Field, Matthew D. Wilkerson, Roopika Menon, Markus Litt-Lampe, Silvia Querings, Konrad Frank, Yon-Dschun Ko, Holger Moch, Denis Moro-Sibilot, Zoe Wainer, Erik Thunnissen, Lukas C. Heukamp, Walter Weder, Danille A. M. Heideman, Stephan Schmitz, Karin Toepelt, Rainer Kappes, Juergen Wolf, Ingelore Boessmann, Gavin M. Wright, Rainer Fricke, Thomas Muley, Martin L. Sos, Joachim H. Clement, Wolfgang Schulte, Christian Brambilla, Sascha Ansén, Viktor Achter, Jean-Charles Soria, D. Neil Hayes, Martin Peifer, Marcel Reiser, Magdalena Bogus

Publikováno v: Seidel, D, Zander, T, Heukamp, L C, Peifer, M, Bos, M, Fernandez-Cuesta, L, Leenders, F, Lu, X, Ansen, S, Gardizi, M, Nguyen, C, Berg, J, Russell, P, Wainer, Z, Schildhaus, H U, Rogers, T M, Solomon, B, Pao, W, Carter, S L, Getz, G, Hayes, D N, Wilkerson, M D, Thunnissen, E, Travis, W D, Perner, S, Wright, G, Brambilla, E, Buttner, R, Wolf, J, Gabler, F, Wilkening, I, Muller, C, Dahmen, I, Menon, R, Konig, K, Albus, K, Merkelbach-Bruse, S, Fassunke, J, Schmitz, K, Kuenstlinger, H, Kleine, M A, Binot, E, Querings, S, Altmuller, J, Bossmann, I, Numberg, P, Schneider, P M, Bogus, M, Soltermann, A, Moch, H, Brustugun, O T, Solberg, S, Lund-Iversen, M, Helland, A, Muley, T, Hoffmann, H, Schnabel, P A, Chen, Y, Groen, H, Timens, W, Sietsma, H, Clement, J H, Weder, W, Sanger, J, Stoelben, E, Ludwig, C, Engel-Riedel, W, Smit, E F, Heideman, D A M, Snijders, P J F, Nogova, L, Sos, M L, Mattonet, C, Topelt, K, Scheffler, M, Goekkurt, E, Kappes, R, Kruger, S, Kambartel, K, Behringer, D, Schulte, W, Galetke, W, Randerath, W, Heldwein, M, Schlesinger, A, Serke, M, Hekmat, K, Frank, K F, Schnell, R, Reiser, M, Hunerliturkoglu, A N, Schmitz, S, Meffert, L, Ko, Y D, Litt-Lampe, M, Gerigk, U, Fricke, R, Besse, B, Brambilla, C, Lantuejoul, S, Lorimier, P, Moro-Sibilot, D, Cappuzzo, F, Ligorio, C, Damiani, S, Field, J K, Hyde, R, Validire, P, Girard, P, Muscarella, L A, Fazio, V M, Hallek, M, Soria, J C, Achter, V, Lang, U & Thomas, R K 2013, ' A Genomics-Based Classification of Human Lung Tumors ', Science Translational Medicine, vol. 5, no. 209, pp. 209ra153 . https://doi.org/10.1126/scitranslmed.3006802
Science Translational Medicine; Vol 5
Science Translational Medicine, 5(209). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 5(209). American Association for the Advancement of Science

We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66843d0f2a6ec2231d73d891ddfa7d52
https://doi.org/10.1126/scitranslmed.3006802

Early Prediction of Nonprogression in Advanced Non-Small-Cell Lung Cancer Treated With Erlotinib By Using [(18)F]Fluorodeoxyglucose and [(18)F]Fluorothymidine Positron Emission Tomography

Autor: Reinhard Buettner, Lukas C. Heukamp, Walburga Engel-Riedel, Thomas Zander, Egbert Smit, Irini Papachristou, Roman K. Thomas, Andreas H. Jacobs, Markus Dietlein, Karin Toepelt, Adriaan Lammertsma, Andreas Draube, Martin Hellmich, Juergen Wolf, Erich Stoelben, Matthias Scheffler, Silvia Querings, Roland T. Ullrich, Karin Schulte, Yon D. Ko, Carsten Kobe, Ronald Boellaard, Lucia Nogova, Michael Hallek, Bernd Neumaier, Andreas Schlesinger

Publikováno v: Zander, T, Scheffler, M, Nogova, L, Kobe, C, Engel-Riedel, W, Hellmich, M, Papachristou, I, Toepelt, K, Draube, A, Heukamp, L, Buettner, R, Ko, Y D, Ullrich, R T, Smit, E F, Boellaard, R, Lammertsma, A A, Hallek, M, Jacobs, A H, Schlesinger, A, Schulte, K, Querings, S, Stoelben, E, Neumaier, B, Thomas, R K, Dietlein, M & Wolf, J 2011, ' Early Prediction of Nonprogression in Advanced Non-Small-Cell Lung Cancer Treated With Erlotinib By Using [(18)F]Fluorodeoxyglucose and [(18)F]Fluorothymidine Positron Emission Tomography ', Journal of Clinical Oncology, vol. 29, no. 13, pp. 1701-1708 . https://doi.org/10.1200/JCO.2010.32.4939
Journal of Clinical Oncology, 29(13), 1701-1708. American Society of Clinical Oncology

Purpose Positron emission tomography (PET) with both 2′-deoxy-2′-[18F]fluoro-d-glucose (FDG) and 3′-[18F]fluoro-3′-deoxy-l-thymidine (FLT) was evaluated with respect to the accuracy of early prediction of nonprogression following erlotinib th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9604a21f24ac1acffe8e95f2c96803f
https://research.vumc.nl/en/publications/e2fdda8e-54e6-4f9c-afef-31a344e84680

Regional screening network for characterization of the molecular epidemiology of non-small cell lung cancer (NSCLC) and implementation of personalized treatment

Autor: Khosro Hekmat, Monika Serke, Lukas C. Heukamp, Erich Stoelben, Thomas Zander, Christian Mattonet, Walburga Engel-Riedel, Ulrich Gerigk, Marc Bos, Konrad Frank, Reinhard Buettner, Marcel Reiser, Stephan Schmitz, Andreas Schlesinger, Sabine Merkelbach-Bruse, Michael Brockmann, Juergen Wolf, Holger Schulz, Yon-Dschun Ko, Jana Fassunke

Publikováno v: Journal of Clinical Oncology. 30:CRA10529-CRA10529

CRA10529 Background: Personalized treatment of genetically stratified subgroups has the potential to substantially improve outcome in NSCLC. A major challenge now is to implement high-quality molecular diagnostics and personalized treatment strategie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f108dc6535006deaa9923db6a7f36d
https://doi.org/10.1200/jco.2012.30.18_suppl.cra10529

Clinical characteristics and natural history of patients with squamous cell lung carcinoma with FGFR1 amplification

Autor: Hans-Ulrich Schildhaus, Ulrich Gerigk, Masyar Gardizi, Reinhard Buettner, Roland Schnell, Monika Serke, Konrad Frank, Juergen Wolf, Marcel Reiser, Khosro Hekmat, Michael Brockmann, Erich Stoelben, Stephan Schmitz, Marc Bos, Lukas C. Heukamp, Yon-Dschun Ko, Walburga Engel-Riedel, Lucia Nogova, Thomas Zander, Andreas Schlesinger

Publikováno v: Journal of Clinical Oncology. 30:1533-1533

1533 Background: FGFR1 amplifications have been described as a promising oncogenic target in squamous cell lung cancer. Here we aimed at describing the clinical characteristics and natural history of FGFR1amplified squamous cell lung cancer patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aafc480751c591e69e8c26c1d6001817
https://doi.org/10.1200/jco.2012.30.15_suppl.1533